Wendy L Frankel, MD

Wendy Frankel


College of Medicine



Academic Title


Research Program

Translational Therapeutics

Research Interest

Cancer ● Adenocarcinoma ● Colorectal Cancer ● Colorectal Cancer, Hereditary Nonpolyposis ● Polyps ● Carcinoma, Hepatocellular ● Pancreatic Cancer ● Adenoma ● Carcinoma ● Microsatellite Instability

Wendy Frankel, MD, is a Distinguished University Professor of Pathology and holder of the Ralph W. and Helen Kurtz Chair in Pathology at Ohio State. She also chairs the Department of Pathology in the College of Medicine, serves as director of the GI/Liver Fellowship and is a member of the Translational Therapeutics Program at the OSUCCC – James.

Dr. Frankel’s primary research interest is colorectal carcinoma and colorectal cancer genetics. She was part of a team that carried out the Columbus-area Hereditary Non-Polyposis Colorectal Cancer (HNPCC) study to determine the prevalence of Lynch syndrome (LS) among all newly diagnosed colorectal and endometrial (uterine) cancer patients.

Results from this study and subsequent publications have changed the standard of care for colorectal cancer patients in the United States, as many institutions have adopted the study’s recommendations to screen these patients for LS (which predisposes to several types of cancer) using immunohistochemistry staining for the four mutated genes that cause it. Dr. Frankel also was involved with the Ohio Colorectal Cancer Prevention Initiative launched by the OSUCCC – James to screen newly diagnosed colorectal cancer patients across the state and their at-risk relatives for LS.

Office Location

E409 Doan Hall

410 W 10th Ave, Columbus, OH 43210



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