Wolfgang Sadee, Dr.rer.nat
College of Medicine
Cancer Biology and Genetics
Neuroblastoma, Allelic Imbalance, Lymphoma, Cancer, Opioid-Related Disorders, Morphine Dependence
Wolfgang Sadee, Dr.rer.nat., is a member of the Translational Therapeutics Program at the OSUCCC – James, where his research focuses on understanding how individual variability in gene expression affects genetic differences in drug responses and toxicity. His research uses a functional genomics-molecular genetics approach to developing biomarker panels that predict drug response and toxicity.Dr. Sadee also directs the College of Medicine’s Center for Pharmacogenomics, which supports multiple clinical studies that are initiated upon discovery of regulatory polymorphisms with likely clinical relevance. Several of his recent studies have discovered genomic variants in drug-metabolizing enzymes—a critical factor in response to therapy for many diseases, including cancer. In addition, Dr. Sadee develops safer opioid analgesics, treatments of opioid addiction and prevention of neonatal abstinence syndrome. Dr. Sadee has co-authored many articles in well-respected publications, including Human Genetics, Human Molecular Genetics, Blood, Circulation Research, Proceedings of the National Academy of Sciences, Journal of Pharmacology and Experimental Therapeutics, Pharmacogenetics and Genomics, BMC Genomics and Clinical Pharmacology & Therapeutics.