Wolfgang Sadee, Dr.rer.nat
College of Medicine
Cancer Biology and Genetics
Neuroblastoma, Allelic Imbalance, Lymphoma, Cancer, Opioid-Related Disorders, Morphine Dependence
I am a member of the Translational Therapeutics Program at the OSUCCC – James, where my research focuses on understanding how individual variability in gene expression causes genetic differences in drug responses and toxicity. My research employs a functional genomics-molecular genetics approach to developing biomarker panels predictive of drug response and toxicity. I also hold the Dr. Samuel T. and Lois Felts Mercer Professorship of Medicine and Pharmacology at Ohio State and serve as director of the College of Medicine’s Center for Pharmacogenomics, which supports multiple clinical studies—prospective and retrospective with the use of existing databases, including genome-wide association studies—that are initiated upon discovery of regulatory polymorphisms with likely clinical relevance. Several of my recent studies have discovered genetic variants in drug-metabolizing enzymes and transporters, a critical factor in response to therapy for many diseases, including cancer. I have co-authored many articles in well-respected publications, including Human Genetics, Human Molecular Genetics, Blood, Circulation Research, Molecular Cancer Therapeutics, PNAS, BMC Genomics, Journal of Pharmacology and Experimental Therapeutics, and Clinical Pharmacology & Therapeutics.