Yuri Pekarsky, PhD
College of Medicine
Cancer Biology and Genetics
Res Asst Professor
Molecular Biology and Cancer Genetics
Cancer, Leukemia, Lymphocytic, Chronic, B-Cell, Leukemia, Leukemia, T-Cell, Lymphoma, T-Cell, Stomach Cancer, Chromosome Aberrations, Breast Cancer, Loss of Heterozygosity, Ataxia Telangiectasia
Yuri Pekarsky, PhD, is a member of the Molecular Biology and Cancer Genetics Program at the OSUCCC – James, where his research focuses on mature T-cell leukemia chromosomal rearrangements.Through the investigation of one chromosomal rearrangement, two related genes—TCL1 and TCL1b—have been identified. Recently, Dr. Pekarsky’s team discovered that, biochemically, TCL1 operates as a co-factor of the Akt kinase, a key regulator of antiapoptotic and proliferative signals. He also has shown that Akt phosphorylates Nur77, a T-cell transcription factor, which blocks its DNA-binding ability and renders the transcription factor inactive. Dr. Pekarsky has co-authored many articles in well-respected publications, including Gene Expression, Blood, Leukemia and Oncotarget.