Yuri Pekarsky, PhD

Yuri Pekarsky


College of Medicine


Cancer Biology and Genetics

Academic Title

Res Asst Professor

Research Program

Molecular Biology and Cancer Genetics

Research Interest

Cancer ● Leukemia, Lymphocytic, Chronic, B-Cell ● Leukemia ● Leukemia, T-Cell ● Lymphoma, T-Cell ● Stomach Cancer ● Chromosome Aberrations ● Breast Cancer ● Loss of Heterozygosity ● Ataxia Telangiectasia

Yuri Pekarsky, PhD, is a member of the Molecular Biology and Cancer Genetics Program at the OSUCCC – James, where his research focuses on mature T-cell leukemia chromosomal rearrangements.

Through the investigation of one chromosomal rearrangement, two related genes—TCL1 and TCL1b—have been identified. Recently, Dr. Pekarsky’s team discovered that, biochemically, TCL1 operates as a co-factor of the Akt kinase, a key regulator of antiapoptotic and proliferative signals.

He also has shown that Akt phosphorylates Nur77, a T-cell transcription factor, which blocks its DNA-binding ability and renders the transcription factor inactive.

Dr. Pekarsky has co-authored many articles in well-respected publications, including Gene Expression, Blood, Leukemia and Oncotarget.

Office Location

1090 Biomedical Research Tower

460 W 12th Ave, Columbus, OH 43210



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