Engineering CRISPR-Cpf1 crRNAs and mRNAs to maximize genome editing efficiency.

Li B, Zhao W, Luo X, Zhang X, Li C, Zeng C, Dong Y
Nat Biomed Eng 1 05/01/2017

Abstract

Cpf1, a type-V CRISPR-Cas effector endonuclease, exhibits gene-editing activity in human cells through a single RNA-guided approach. Here, we report the design and assessment of an array of 42 types of engineered

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