F-Box Protein-Mediated Resistance to PARP Inhibitor Therapy.

Adamovich AI, Toland AE, Parvin JD
Mol Cell 73 195-196 01/17/2019


PARP inhibitor (PARPi) therapy targets BRCA1/2 mutant tumor cells, but acquired resistance limits its effectiveness. In this issue of Molecular Cell, Marzio et al. (2019) identify a novel mechanism of resistance to PARPi through regulation of RAD51 protein stability via an SCF ubiquitin ligase dependent on EMI1.

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