Fratricide of NK Cells in Daratumumab Therapy for Multiple Myeloma Overcome by Ex Vivo-Expanded Autologous NK Cells.

Wang Y, Zhang Y, Hughes T, Zhang J, Caligiuri MA, Benson DM, Yu J
Clin Cancer Res 24 4006-4017 08/15/2018

Abstract

Daratumumab and its use in combination with other agents is becoming a new standard of care for the treatment of multiple myeloma. We mechanistically studied how daratumumab acts on natural killer (NK) cells.

Full Text