How Long of a Dynamic 3'-Deoxy-3'-[18F]fluorothymidine ([18F]FLT) PET Acquisition Is Needed for Robust Kinetic Analysis in Breast Cancer?

Zhang J, Liu X, Knopp MI, Ramaswamy B, Knopp MV
Mol Imaging Biol in press 07/09/2018

Abstract

PURPOSE: To quantitatively evaluate the minimally required scanning time of 3'-deoxy-3'-[

PROCEDURES: Within a therapeutic intervention trial, 26 breast tumors of 8 breast cancer patients were analyzed from 30-min dynamic [

RESULTS: The correlation of kinetic parameters between the gold standard and the abbreviated dynamic data series increased with longer T

CONCLUSIONS: This study indicates that a 16-min dynamic PET acquisition appears to be sufficient to provide accurate [

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