Mediation of Associations Between Adiposity and Colorectal Cancer Risk by Inflammatory and Metabolic Biomarkers.

Petimar J, Tabung FK, Valeri L, Rosner B, Chan AT, Smith-Warner SA, Giovannucci EL
Int J Cancer in press 12/06/2018

Abstract

Inflammation and hyperinsulinemia may drive associations between adiposity and colorectal cancer (CRC) risk, but few studies have examined this hypothesis using mediation analysis. We used inverse odds ratio weighting and logistic regression to calculate odds ratios (OR) and 95% confidence intervals (CI) for estimated total effects (OR

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