Preparation of Targeted Anionic Lipid-Coated Polyplexes for MicroRNA Delivery.

Huang X, Zhang M, Wang X, Lee LJ, Lee RJ
Methods Mol Biol 1445 201-13 01/01/2016

Abstract

As nonviral nucleic acid delivery vehicles, lipid nanoparticles (LNPs) have been widely used. Here we describe the synthesis and evaluation of LNPs based on targeted anionic lipid-coated polyplexs for therapeutic delivery of microRNA (miRNA) mimics. These LNPs are particularly suited for therapeutic delivery of oligonucleotide agents to leukemia cells.

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