Targeting BRAF Mutations in High-Grade Neuroendocrine Carcinoma of the Colon.

Burkart J, Owen D, Shah MH, Abdel-Misih SRZ, Roychowdhury S, Wesolowski R, Haraldsdottir S, Reeser JW, Samorodnitsky E, Smith A, Konda B
J Natl Compr Canc Netw 16 1035-1040 01/01/2018

Abstract

Mutations in the RAS/RAF/MEK/ERK pathway leading to constitutive activation and uncontrolled cellular growth have been identified in various human malignancies, making this pathway a target for potential therapeutics. The activating

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