Targeting BRAF Mutations in High-Grade Neuroendocrine Carcinoma of the Colon.
Burkart J, Owen D, Shah MH, Abdel-Misih SRZ, Roychowdhury S, Wesolowski R, Haraldsdottir S, Reeser JW, Samorodnitsky E, Smith A, Konda B
J Natl Compr Canc Netw 16 1035-1040 01/01/2018
Mutations in the RAS/RAF/MEK/ERK pathway leading to constitutive activation and uncontrolled cellular growth have been identified in various human malignancies, making this pathway a target for potential therapeutics. The activatingFull Text