Research Labs

OSUCCC – James investigators make advances against cancer in research laboratories located in buildings around Ohio State’s Wexner Medical Center and across The Ohio State University campus. Most are just a short walk from Ohio State’s new James Cancer Hospital and Solove Research Institute.

It is in these labs that Ohio State cancer researchers are working with graduate students, postdoctoral researchers and in some cases undergraduate students—to gain new knowledge about the causes, treatment, diagnosis and prevention of cancer. Their work ranges from basic molecular and cellular science to translational studies designed to find and bring new treatments quickly to patients, and to clinical trials that evaluate the safety and effectiveness of experimental treatments in patients. This research is reducing cancer incidence in human populations and improving the quality of life for cancer survivors.

Blachly Lab

The goal of the Blachly Lab is to leverage emerging genome technologies to advance the understanding and treatment of leukemia.

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Christin Burd Lab

The Christin Burd Lab studies the role that genetic and environmental factors play in melanoma initiation, progression and therapeutic response.

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Craig Burd Lab

The Craig Burd Lab studies the molecular mechanisms controlling the estrogen receptor’s activity and how these mechanisms influence breast cancer risk and therapeutic relapse.

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Cao Lab

The Cao Lab studies the impact of physical environment and mental state on physiological processes and disease pathology.

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Carson Lab

The Carson Lab is interested in the translation of basic science discoveries in the field of immunology into clinical treatments for cancer.

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Chakravarti Lab

The Chakravarti Lab studies the molecular, genetic and epigenetic mechanisms of treatment resistance in human tumors.

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Cherian Lab

The Cherian Lab is dedicated to improving the quality of life for patients with breast cancer by using clinical data to formulate treatment strategies and develop novel therapies.

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Coppola Lab

The Coppola Lab studies the biological role of a new scaffold protein named RanBP9, which interacts with many major players of the hallmarks of cancer.

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Cruz-Monserrate Lab

The Cruz-Monserrate Lab is interested in understanding molecular mechanisms in the development of pancreatic cancer.

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de la Chapelle Lab

The de la Chapelle Lab focuses on the mapping, cloning and characterization of high- and low-penetrance genes for cancer predisposition.

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Denko Lab

The Denko Lab aims to understand how stresses with the tumor microenvironment can influence tumor cell malignant progression and the response of solid tumors to therapeutic interventions.

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Experimental Hematology Lab

The Experimental Hematology team at the OSUCCC – James is dedicated to cutting-edge research to advance innovative treatments for patients with blood cancers and other blood diseases.

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Ghoshal Lab

The Ghoshal Lab focuses on elucidating the functions of microRNAs and the factors involved in DNA methylation/hydroxymethylation in liver biology.

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Deliang Guo Lab

The goals of the Deliang Guo Lab are to define effective therapeutic targets and drugs to treat malignant malignancies and avoid their resistance.

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Peixuan Guo Lab

The Peixuan Guo Lab is dedicated to developing targeted cancer therapies that result in highly efficient anti-cancer medications and treatments.

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Hertlein Lab

The Hertlein Lab is dedicated to pioneering new therapies for AML and CLL, promoting faster recovery times and even better outcomes.

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Hu Lab

The Hu Lab focuses on focuses on identifying novel oncotargets in the tumor microenvironment and developing corresponding targeted therapies.

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Naduparambil Jacob Lab

The Naduparambil Jacob Lab focuses its research on translational radiation biology, particularly related to lung cancer metastasis.

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Samson Jacob Lab

The Samson Jacob Lab focuses its research on the epigenetic sequencing of tumor suppressor genes and the role of microRNAs in the initiation and progression of hepatocellular carcinoma and breast cancer.

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Kwon Lab

The Kwon Lab studies the etiology, tumor drivers and putative therapies relevant to malignant glioma.

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Lapalombella Lab

The Lapalombella Lab is dedicated to identifying novel epigenetic therapies for hematological malignancies.

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Zihai Li Lab

The Zihai Li Lab focuses on chaperone biology, immune tolerance and cancer immunology.

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Long Lab

The Long Lab is dedicated to using small-molecule drugs to enhance the efficacy and outcomes of immunotherapy for leukemia patients.

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Muthusamy Lab

The Muthusamy Lab is dedicated to characterizing leukemic stem cells and finding ways to eradicate them to prevent disease relapse.

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Padamsee Group

The Padamsee Group is dedicated to understanding the unique challenges and concerns of the diverse group of women at high risk for breast or ovarian cancer.

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Papandreou Lab

The Papandreou Lab investigates microenvironmental determinants of cancer metabolism and malignant progression.

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Pollock Lab

The Sarcoma Research Laboratory is a translational investigative environment focusing on soft tissue sarcoma and related malignancies led by Raphael Pollock, MD, PhD.

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Puduvalli Lab

The Puduvalli Lab is focused on studies related to the epigenetics of brain tumors and novel therapeutic strategies against brain tumors.

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Rocco Lab

The Rocco Lab studies the biological basis of two molecular markers shown to be associated with head and neck cancer outcome: intra-tumor heterogeneity and estrogen-receptor signaling.

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Roychowdhury Lab

Research conducted by the Roychowdhury Lab includes basic cancer research and translational cancer genomics.

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Shields Lab

The Shields Lab pursues basic science discovery that improve clinical medicine. It conducts molecular epidemiology studies from the laboratory to the community.

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Gina Sizemore Lab

Research in the Gina Sizemore Lab focuses on the role of the tumor microenvironment in treating patients with metastatic breast cancer.

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Steven Sizemore Lab

The Steven Sizemore Lab investigates the mechanisms that drive cancer metastasis and seeks to develop novel therapies for the treatment of metastatic disease.

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Stover Lab

The Stover Lab is interested in identifying predictive markers for treatment response and novel susceptibilities that allow us to overcome drug resistance.

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Summers Lab

The Summers Lab focuses its research on the control of genome stability.

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Toland Lab

The Toland Lab studies genetic susceptibility to cancer for colon, breast and cutaneous squamous cell carcinoma.

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Venere Lab

The goal of the Venere Lab is to elucidate points of fragility for glioblastoma and exploit these findings to develop new treatment modalities and improve on current standard of care therapies.

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Wagener Lab

The Wagener Lab conducts clinical and laboratory-based research spanning tobacco regulatory science, tobacco harm reduction and public health.

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Qi-En Wang Lab

The Qi-En Wang Lab is focused on cancer stem cell biology, DNA repair and chemotherapy resistance.

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Ruoning Wang Lab

The Ruoning Wang Lab's fundamental interest is to understand how eukaryotic cells integrate extracellular and intrinsic signals to dictate cellular fate.

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Welliver Lab

The goal of the Welliver Lab is to understand tumor specific metabolism and cell death pattern after cancer therapy in order to develop novel strategies to eliminate tumor recurrence.

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Wen Lab

The Wen Lab studies the immune function and inflammation in the development of colorectal cancer (CRC).

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Williams Lab

The Williams Lab focuses on DNA damage response pathways and novel mechanisms of radiosensitization.

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Woyach Lab

The Woyach Lab is dedicated to studying novel therapeutics in chronic lymphocytic leukemia (CLL) with the goal of translating preclinical findings to patient care.

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Zhang Lab

The focus of the Zhang Lab is to study the DNA damage response and investigate how it can be exploited for personalized medicine.

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