The Carson laboratory, led by William E. Carson III, at The Ohio State University is interested in the translation of basic science discoveries in the field of immunology into clinical treatments for cancer. Our research focuses on factors that influence the immune response to cancer cells, especially in the setting of breast cancer and malignant melanoma.
The Carson laboratory focuses our research on three main areas.
The use of cytokines either alone or in combination with targeted agents to treat malignant melanoma tumors. The Carson lab is interested in the mechanism of interferon-alpha and ways to enhance its antitumor actions. Targeted agents of interest to our group include proteasome inhibitors, antiangiogenic agents such as bevacizumab, and several tyrosine kinase inhibitors. Notably, many of these agents display synergistic antitumor activity when combined with immune-based treatments.
The use of cytokines to enhance the actions of antitumor monoclonal antibodies (mAb). We have observed that co-administration of IL-12 can potentiate the antitumor actions of an anti-HER2/neu mAb (trastuzumab or Herceptin) that is used to treat patients with HER2/neu-expressing breast cancers. This data has served as the basis for several NCI-sponsored phase I clinical trials that employ mAbs in combination with IL-12. Recent work from our lab indicates that other immune stimulatory agents may be able to augment the immune response to antitumor mAbs. Agents that are under investigation include toll-like receptor agonists and novel cytokines such as IL-21.
The effects of stress on the immune system of patients diagnosed with cancer. We hypothesize that stress can significantly inhibit the host immune response in the setting of cancer and have discovered that natural killer (NK) cell function provides an important "window" into this process. We are collaborating with Barbara Andersen, PhD, in the Department of Psychology, who is investigating the effects of behavioral and psychological interventions on the immune function of women with stage II and III breast cancer. Our goal is to define the mechanisms that underlie the altered immune response of cancer patients and explore ways to reverse this inhibition to enhance the effects of immune-based therapies.
Our laboratory is well suited for the physician-scientist in training or postdoctoral researcher interested in discovery for the sake of clinical application.
Training in Tumor Immunology
Study the immune system and how it fights cancer!
The Ohio State T32 Training Program in Tumor Immunology is dedicated to the education of post-doctoral researchers in this area.
- Receive on-on-one instruction from an established investigator
- Tailor your coursework
- Learn about genomics, proteomics and bioinformatics
- Learn grant-writing and project management
- Travel to scientific meetings
Applicants must be a U.S. Citizen or green card holder and be willing to spend two years performing basic research in an immunology lab at The Ohio State University.
Women, minority and disabled applicants are especially encouraged to apply. Applications will be accepted through 6:00pm on Monday, June 2nd, 2015. Start date will be July 1st, 2015.
Contact Dr. Carson at firstname.lastname@example.org.
Postdoctoral Pelotonia Fellowship Program
The Pelotonia Fellowship Program provides two-year research fellowships for up to 12 of the brightest and most promising postdoctoral candidates who want to help cure cancer. Cancer is a complex disease and curing it will take a multidisciplinary effort. So, no matter what the field of study, from the traditional science fields to fields such as history, business and computer science, any postdoctoral candidate may apply.
October – December 2015
- Elizabeth McMichael attended the SITC conference and gave a poster presentation of her work with IL-21 and cetuximab in pancreatic cancer.
- Megan Duggan attended the Society for Melanoma Research 2015 Melanoma Conference and gave a poster presentation of her work with NRAS isoforms in melanoma.
June – September 2015
- Amanda Campbell (Harper) was awarded a Graduate Student Pelotonia Fellowship and Megan Duggan was awarded a SIB T32 Training Fellowship from the BSGP at Ohio State.
- MD/PhD candidates Amanda Campbell and Andrew Stiff were selected to give oral presentations at the MSTP summer retreat.
- Nick Courtney joined the Carson Lab as an undergraduate research associate.
- BSGP first year graduate student Bailey Dye began rotating in the lab. Bailey is working on a project looking at the different isoforms of NRAS in sarcomas.
- NIH T32 postdoctoral fellow Lorena Suarez-Kelly joined the Carson Lab following her residency at Memorial University.
April – June 2015
- Undergraduate SUCCESS student Michelle Culbertson joined the Carson lab for the summer from her home institution of Arizona State University.
- Graduate student Elizabeth McMichael gave her talk, entitled, “IL-21 enhances natural killer cell activity against cetuximab-coated pancreatic tumor cells” at the OSU Department of Surgery Research Day. Dr. Nicholas Latchana also presented his talk, entitled, “Classification of Indeterminate Melanocytic Lesions by MicroRNA Profiling.”
- Dr. Nicholas Latchana won 1st place in Oncology at the Annual American College of Surgeons Ohio Chapter Meeting for his oral presentation on Global MicroRNA Profiling of Indeterminate Melanocytic Lesions.
January – March 2015
- Carson Lab undergraduates Gonzalo Nico Olaverria Salavaggione and Tiffany Noel were awarded Summer Undergraduate Research Institute scholarships to work in the lab full time over the summer of 2015.