Christin Burd Lab

Areas of Interest

Melanoma

Melanoma incidence continues to climb in the United States, with over 76,000 new cases diagnosed each year. While early stage melanomas are frequently cured by surgical excision, the treatment of metastatic tumors remains a major challenge for oncologists. Our laboratory uses patient samples, cell culture and mouse models to better understand genetic and environmental factors that play a role in melanoma initiation, progression and therapeutic response.  Ongoing studies focus on developing improved methods to prevent, treat and diagnose melanoma.

Connecting Cancer and Aging

The likelihood of being diagnosed with cancer increases dramatically with age. Many physiological changes associated with aging may contribute to this observation (e.g. cumulative cellular damage, immunological declines); however, the exact processes linking these two conditions are unknown. As the average age of cancer diagnosis continues to increase and treatments become more efficacious, we need a better means of predicting long-term drug toxicities and patient outcomes. In collaboration with OSU oncologists, we are working to define the relationship between cancer and aging. We aim to develop quantitative blood tests to determine how well a patient will tolerate and respond to a particular therapy as well as how cancer drugs will impact their long-term health and well-being. Laboratory investigations are used to probe molecular pathways associated with age-related physiological declines and adverse patient outcomes. With increased knowledge in these areas, we hope to improve the healthy lifespan of cancer patients and survivors.

Contact Us

Assistant Professor
Departments of Molecular Genetics and Molecular and Cellular Biochemistry
Biomedical Research Tower, Rm 586
460 W. 12th Avenue
Columbus, OH 43210

Office Phone: 614-688-7569
Email: burd.25@osu.edu

Lab Location and Contact Information

Biomedical Research Tower, Rm 550
460 W. 12th Avenue
Columbus, OH 43210

Lab Phone: 614-688-6571 

Members

James Gillahan, Research Technician

Xiangnan Guan, Molecular Genetics Graduate Student

Kyle LaPak, MCDB Graduate Student

Meriam Waqas, Molecular Genetics Graduate Student

Andrea Holderbaum, OSU Undergraduate

Reena Underiner, OSU Undergraduate

Michael Butrey, OSU Undergraduate

CCC Members

Christin Burd, PhD

The INK4/ARF locus encodes three tumor suppressor genes frequently lost or silenced in human cancers (p15INK4b, p16INK4a, and p14ARF). Dr. Burd's lab aims to faithfully recapitulate the genetics of these tumors through the development of genetically engineered mouse models.

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