Zhiwei Hu, MD, PhD, is a member of the Translational Therapeutics Program at the OSUCCC – James, where his research focuses on identifying novel oncotargets in tumor microenvironment and developing corresponding targeted therapies, including immunotherapy, photodynamic therapy and gene therapy. He has more than 20 years of experience in tumor immunology, antibody immunotherapy and neovascular-targeting therapies.
Dr. Hu came to The Ohio State University from Yale University. During his tenure at Yale, he and Alan Garen, PhD, co-invented and tested the first TF-targeting agent, a factor VII-IgG1Fc immunoconjugate (called ICON) with the ability to target cancer cells, cancer stem cells and tumor neovasculature for the treatment of solid cancers. Dr. Hu holds five U.S. patents and four international patents for ICON and its uses. As a neovascular-targeting agent, ICON has shown therapeutic efficacy in preclinical studies for treating angiogenesis-dependent diseases, notably cancer, age-related macular degeneration (AMD) and endometriosis. ICON has entered phase I and II clinical trials for macular degeneration patients.
In 2010, Dr. Hu co-developed another neovascular-targeting therapeutic, called factor VII-targeted PDT (fVII-tPDT), for cancer and wet macular degeneration. Recently, he invented a second-generation TF-targeting ICON (called L-ICON) that hasseveral improvements, making it more effective than first-generation ICON for immunotherapy of cancer. His long-term research goal is to translate tissue factor-targeting immunotherapy and photodynamic therapy as monotherapy and combination therapies with immune modulatory agents and natural killer cells into the clinic for cancer patients with difficult-to-treat malignancies, including triple-negative breast cancer and advanced melanoma.
Zi Li – Student Lab Assistant I (2013), Ohio State Undergraduate Student (graduated)
Shengjia Gao – Student Lab Assistant I (2031-2014), Ohio State Undergraduate Student (graduated)
Qikun Zhang – Visiting Scholar from China (2014-2015)
Benjamin Dumm – Summer College Student Volunteer (from Grove City College) (2016)
Yingshi Guo – Research Assistant II (2016)
Keliang Gao – Research Assistant II (2016)
Elizabeth McMichael – PhD student (co-mentored with William Carson, MD) (2016) (graduated in 2016)
Amanda Campbell – MD/PhD student (co-mentored with William Carson, MD) (2015)
Meghan Flannery – master’s degree student (graduated with honors in 2015)
Meghan Flannery – PhD student (current)