Ruoning Wang Lab
Our lab's fundamental interest is to understand how eukaryotic cells integrate extracellular and intrinsic signals/cues to dictate cellular fate (cell proliferation, death, growth and differentiation). In particular, we focus on understanding the impact of the interplay between cell metabolic programs and cell-signaling cascades in patho-physiological contexts such as oocyte maturation, tumorigenesis and immune response.
Each of our experimental models has unique biological and technical features, including mouse models of human tumors and autoimmune disease (accessible for genetic and pharmacological modulations), frog oocytes (with defined cell cycle stage and accessibillity for direct intracellular injection of biological material) and primary cells such as MEFs, lymphocytes and macrophages (with defined genetic background, accessible to genetic modulation and responsive to various patho-physiological stimulations).
Our current long-term projects include:
- Dissecting the molecular and biochemical nature of metabolic checkpoint, a mechanism of transducing metabolic signals (often reflected by the change of cellular metabolites) to control cell proliferation and death;
- Deciphering metabolic reprogramming in immunity and evaluating the impact of metabolic modulation on immunity;
- Understand the mechanism and therapeutic aspects of oncogenic addiction and metabolic addiction of pediatric cancer (neuroblastoma, rhabdomyosarcoma, etc.)
Lingling Liu, PhD – research scientist, Lingling.Liu@nationwidechildrens.org
Tingting Wang, PhD – postdoctoral fellow, Tingting.Wang@nationwidechildrens.org
Xuyong Chen – postdoctoral scientist, Xuyong.Chen@nationwidechildrens.org
Josephin Gnanaprakasam – postdoctoral scientist, Josephin.Gnanaprakasam@nationwidechildrens.org
Siwen Kang – postdoctoral scientist, Siwen.Kang@nationwidechildrens.org
Ruohan Wu – graduate student, Ruohan.Wu@nationwidechildrens.org
John Sherman – graduate student, John.Sherman@nationwidechildrens.org
Xuequn Xu – senior research associate, Xuequn.Xu@nationwidechildrens.org