Ruoning Wang Lab

Our lab's fundamental interest is to understand how eukaryotic cells integrate extracellular and intrinsic signals/cues to dictate cellular fate (cell proliferation, death, growth and differentiation). In particular, we focus on understanding the impact of the interplay between cell metabolic programs and cell-signaling cascades in patho-physiological contexts such as oocyte maturation, tumorigenesis and immune response.

Each of our experimental models has unique biological and technical features, including mouse models of human tumors and autoimmune disease (accessible for genetic and pharmacological modulations), frog oocytes (with defined cell cycle stage and accessibillity for direct intracellular injection of biological material), and primary cells such as MEFs, lymphocytes and macrophages (with defined genetic background, accessible to genetic modulation, and responsive to various patho-physiological stimulations).

Our current long-term projects include:

  • Dissecting the molecular and biochemical nature of metabolic checkpoint, a mechanism of transducing metabolic signals (often reflected by the change of cellular metabolites) to control cell proliferation and death;
  • Deciphering metabolic reprogramming in immunity and evaluating the impact of metabolic modulation on immunity;
  • Understand the mechanism and therapeutic aspects of oncogenic addiction and metabolic addiction of pediatric cancer (neuroblastoma, rhabdomyosarcoma, etc.)

Members

Ruoning Wang, PhD
Principal Investigator, Center for Childhood Cancer and Blood Disease, The Research Institute at Nationwide Children's Hospital
Assistant Professor, Department of Pediatrics, The Ohio State University School of Medicine
700 Children's Drive, Rm. WA5016
Columbus, OH  43205-2696

Office Phone: 614-355-2980
Lab Phone: 614-355-2660
Fax: 614-722-5895
Email: ruoning.wang@nationwidechildrens.org

Lingling Liu, PhD
Research Scientist, Center for Childhood Cancer and Blood Disease, The Research Institute at Nationwide Children's Hospital
700 Children's Drive, Rm. WA5105
Columbus, OH  43205-2696

Email: Lingling.Liu@nationwidechildrens.org

Tingting Wang, PhD
Postdoctoral Fellow, Center for Childhood Cancer and Blood Disease, The Research Institute at Nationwide Children's Hospital
700 Children's Drive, Rm. WA5105
Columbus, OH  43205-2696

Email: Tingting.Wang@nationwidechildrens.org

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