Program Project Grants
Program Project Grants (PPGs) support broadly based, multidisciplinary, often long-term research projects that have a major objective or theme. PPGs generally involve a relatively large group and subprojects directed toward understanding various aspects or components of the central objective.
Improving Uptake of Cervical Cancer Prevention Services in Appalachia
PI: Electra Paskett, PhD
Building upon our long history of collaborative research and community partnerships, this project will test the effectiveness of health system-based interventions focused on tobacco use, HPV vaccination and cervical cancer screening (Pap test and/or self-testing with follow-up of positive tests) as part of an integrated clinic-based cervical cancer prevention program in health systems in four Appalachian states. If successful, this project will provide evidence for a novel and innovative approach to address disparities in underserved communities with plans for sustainability and dissemination, as well as cost-effectiveness data.
Endoplasmic Reticulum Chaperones in Cancer Biology and Therapy
PI: Zihai Li, MD, PhD
This project focuses on grp94, a molecule that is highly expressed in cancer cells, whose atomic structure has been resolved and whose “drug-like” inhibitors have been discovered by the applicants of this proposal. Completion of the proposed studies will enrich the knowledge of grp94, uncover its cancer-specific roles and identify its targeted inhibitors for eventual clinical development of novel cancer therapeutics.
OSU Center of Excellence in Regulatory Tobacco Science (OSU-CERTS)
PI: Mary Ellen Wewers, RN, PhD, MPH; Peter Shields, MD
The overall vision of The Ohio State University Center of Excellence in Regulatory Tobacco Science (OSU-CERTS) is to serve as a national leader in providing relevant scientific data to support FDA regulatory decision-making in the Center for Tobacco Products. OSU-CERTS will conduct a series of projects to provide information about the relationships between ever-changing diverse types of tobacco product use among rural (Appalachian Ohio) and urban (Columbus, OH) adolescents and adults at risk for tobacco-attributable disease and death. The goal is to improve public health and reduce population harm from tobacco product use.
Retrovirus Models of Cancer
PI: Patrick Green, PhD
Approximately 15-25 million people worldwide are infected with HTLV-1 with a small percentage developing adult T-cell leukemia. The cancer is aggressive and there is currently no effective treatment. The interactive nature of this PPG will provide rationale hypotheses to support translational studies to define therapeutic intervention against retrovirus-induced lymphoma and refine animal models to determine molecular determinants of retrovirus-induced cancer.
Discovery of Anticancer Agents of Diverse Natural Origin
PI: A. Douglas Kinghorn, PhD
The goal of this program project is to discover novel chemicals from selected tropical rainforest plants, as well as cyanobacteria and fungi, for development as cancer chemotherapeutic agents, particularly for tumors not cured by present treatment methods.