Statewide Endometrial Cancer Initiative

OPTEC (Ohio Prevention and Treatment of Endometrial Cancer) is a statewide initiative to help identify women with endometrial cancer who may be at risk for other types of cancers due to their genetic makeup, and to help match women with endometrial cancer to the best treatment options for their particular cancer.

Some endometrial cancer results from an inherited condition called Lynch syndrome. While Lynch syndrome is rare — only about 5 in 100 people with endometrial cancer have Lynch syndrome — it greatly increases the chance of developing many other types of cancer.

Women enrolled in OPTEC will receive free screening for Lynch syndrome. Additionally, as part of the OPTEC initiative, we will establish a registry for patients and their families with Lynch syndrome. All women enrolled in OPTEC will receive free tumor testing to identify the molecular changes that are causing their endometrial cancer, regardless of whether or not they are found to be likely to have Lynch syndrome. This testing may allow us to identify the best therapy or clinical trial to treat each individual cancer.

Patients eligible for the OPTEC study:

  • Are at least 18 years old
  • Have a newly diagnosed endometrial cancer
  • Are undergoing hysterectomy or surgery at a participating Ohio hospital

What will happen if I decide to participate?

Donate blood & tissue

  • You will be asked to donate a small sample of blood and a small piece of endometrial cancer tumor from the hospital where you had (or will have) your surgery.
  • You also will be asked to sign a medical records release form and to contribute your leftover samples (tumor and blood) to the OPTEC sample bank, which can help future endometrial cancer studies.

Complete a study questionnaire

  • You will be asked to complete a questionnaire assessing risk factors for endometrial cancer. This may help us learn more about the causes of endometrial cancer and ways to prevent it in the future.

Screen for Lynch syndrome

  • The characteristics of your endometrial cancer or tumor help indicate whether or not you could have Lynch syndrome. If your tumor is characteristic of Lynch syndrome, you will be offered free genetic counseling and testing.
  • If you undergo genetic testing, your blood will be tested for mutations or changes in the genes that are known to cause Lynch syndrome.

What if I have Lynch syndrome?

If genetic testing shows you have Lynch syndrome, the OPTEC initiative will provide free genetic counseling and testing for your biological family members; that way, your family members can learn more about their own cancer risks. If you have Lynch syndrome, you will also have the opportunity to participate in other research studies, including clinical trials addressing the personalized and targeted treatment of your endometrial cancer.

How do I join OPTEC?

If you are eligible and interested in participating in the initiative, talk with your local healthcare provider. It’s important to consider the risks and benefits of participating in OPTEC. A member of the OPTEC study team will discuss those with you before you provide consent to join the study.

For more information:

The Ohio Prevention and Treatment of Endometrial Cancer (OPTEC) Initiative

The Ohio State University Comprehensive Cancer Center – James Cancer Hospital and Solove Research Institute

The Ohio State University Wexner Medical Center, Department of Obstetrics and Gynecology


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