Meet the leaders and members of the Molecular Biology and Cancer Genetics research program at the OSUCCC – James who promote improved screening, diagnosis, prognosis and treatment.

Leaders

Matthew Ringel, MD

Dr. Ringel's research interests include molecular mechanisms involved in thyroid cancer invasion and metastasis; with an active interest in new drug testing for thyroid cancer therapy.

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Members

Mohamed Abdel-Rahman, MD, PhD

Mohamed Abdel-Rahman, MD, PhD, is a member of the Molecular Biology and Cancer Genetics Program at the OSUCCC – James, where he focuses his research on molecular diagnosis of ocular melanoma, identification of novel targets for ocular melanoma therapy and hereditary predisposition to ocular

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Rene Anand, MS, PhD

As a member of the Molecular Biology and Cancer Genetics team at the OSUCCC – James, Rene Anand, PhD, along with his laboratory, has recently developed human adult stem cell (iPSC) derived models of cancer, autism and Alzheimer’s disease. In particular, Dr. Anand’s work focuses on understanding.

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Paul Andreassen, PhD

Paul Andreassen, PhD, is a member of the OSUCCC – James Molecular Biology and Cancer Genetics Program. He is based at Cincinnati Children’s Hospital Medical Center.

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Rami Aqeilan, PhD

Rami Aqeilan, PhD, is a member of the Molecular Biology and Cancer Genetics Program at the OSUCCC – James. His work explores the molecular aspect of cancer biology in an effort to uncover the genes that contribute to transforming an incipient cancer cell.

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Kellie Archer, PhD

Kellie Archer, PhD, is a member of the Molecular Biology and Cancer Genetics Program at the OSUCCC – James and chair of the Division of Biostatistics in The Ohio State University College of Public Health. Her work focuses on developing statistical methods and software to analyze data from.

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Bruce Aronow, PhD

As a member of the OSUCCC – James Molecular Biology and Cancer Genetics Program, Bruce Aronow, PhD, works with investigators in diverse areas to use technologies that measure gene activity, variation and mutation across the genome. He is based at Cincinnati Children’s Hospital Medical Center.

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Christin Burd, PhD

Christin Burd, PhD, is a member of the Molecular Biology and Cancer Genetics Program at the OSUCCC – James, where she focuses her research on improving our understanding of the connections between cancer and aging. Her team’s goal is to bridge bench science and clinical trials.

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Hakan Cam, PhD

Cancer is a genetic disorder caused by mutations in genes critically involved in the control of cell proliferation. Long-lived organisms, such as humans, have evolved strategies to restrict the development of potentially malignant cells.

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Lei Cao, PhD

Lei Cao, PhD, is a member of the Molecular Biology and Cancer Genetics Program at the OSUCCC – James. Dr. Cao’s research has characterized a novel brain-fat axis underlying the antiobesity and anticancer phenotypes involved in a complex environment.

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Colleen Cebulla, MD, PhD

Colleen Cebulla, MD, is a member of the Molecular Biology and Cancer Genetics Program at the OSUCCC – James, where her research is focused on retinal detachments and uveal melanoma. Her research team has identified that over 10 percent of patients with uveal melanoma have a heritable cancer.

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Dawn Chandler, PhD

Dawn Chandler, PhD, is a member of the Molecular Biology and Cancer Genetics Program at the OSUCCC – James, where her work focuses on the regulation of pre-mRNA splicing and how its disruption can lead to pediatric diseases such as cancer. In one recent study, her team’s research identified.

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Lionel Chow, MD, PhD

Lionel Chow, MD, PhD, is a member of the Molecular Biology and Cancer Genetics Program at the OSUCCC – James, where his research focuses on glioblastoma multiforme and angiosarcoma. Dr. Chow’s work has led to the development of robust laboratory models for this disease that are now used to.

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Susan Cole, PhD

The Notch signaling pathway plays key roles in human development and disease. Disregulation of Notch signaling is frequently seen in human cancers, for instance, activating Notch mutations are seen in over 50% of juvenille T-ALL cases.

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Vincenzo Coppola, MD

Vincenzo Coppola, MD, is a member of the Molecular Biology and Cancer Genetics Program at the OSUCCC – James. He is also the director of the Genetically Engineered Mouse Modeling Core (GEMMC) Shared Resource to assist other OSUCCC members in generating mouse models of human cancer and to study.

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Carlo Croce, MD

Dr. Croce studies the molecular changes in genes that lead to cancer. He is particularly interested in the early changes of malignancy and how they might serve as targets for new treatment and preventive agents.

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Biplab Dasgupta, PhD

Biplab Dasgupta, PhD, a member of the Molecular Biology and Cancer Genetics Program at the OSUCCC – James, is based at Cincinnati Children’s Hospital Medical Center. His research seeks to learn how neural cell/stem-cell metabolic and energy status is linked to cell cycle, lineage commitment.

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Albert de la Chapelle, MD, PhD

Research in Dr. de la Chapelle’s laboratory focuses on the mapping, cloning, and characterization of high-and low-penetrance genes for cancer predisposition. When new genes are identified, studies are directed to determine the pathophysiological role of the proteins or RNA molecules they encode.

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Nicholas Denko, MD, PhD

Nicholas Denko, MD, PhD, a member of the Molecular Biology and Cancer Genetics Program at the OSUCCC – James, is the co-holder of two U. S.

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James DeWille, PhD

Dr. DeWille's research includes the molecular mechanisms of growth regulation.

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Richard Fishel, PhD

Dr Fishel’s research interests includes DNA Repair defects and Genomic Instability in cancer development; biophysical chemistry of DNA repair; and single molecule imaging in vitro and in vivo. His laboratory studies the mechanisms, genetics, regulation, and consequences of DNA repair and genome.

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Harold Fisk, PhD

Centrosomes are microtubule-organizing structures that coordinate mitotic spindle assembly and chromosome segregation. Centrosome aberrations are found in a variety of tumors, and are associated with tumorigenesis in breast cancer, prostate cancer, and leukemia.

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Michael Freitas, PhD

Dr. Freitas' lab has developed extensive expertise in the field of clinical/translational proteomics, biomarker discovery/validation and bioinformatics for mass spectrometry based proteomics. Their work focuses on the determination of side chain modifications of proteins important in Chromatin.

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Ramesh Ganju, PhD

The major focus of Dr. Ganju's lab is to determine the role of chemokines, especially CXCL12, and various inflammatory molecules, such as S100A7, and anti-inflammatory molecules, such as Slit2 and cannabinoids, in pathogenesis of various diseases.

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Samir Ghadiali, PhD

As part of an NSF funded project, Dr. Ghadiali uses engineering, biophysical and molecular/cell biology techniques to identify how biomechanical properties of both cancer cells and the tumor microenvironment (TME) influence oncogenic epithelial to mesenchymal transition (EMT). Dr. Ghadiali also.

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Paul Goodfellow, PhD

Dr. Goodfellow’s research focuses on understanding the role that loss of DNA mismatch repair plays in tumor initiation and progression and understanding key molecular events that can be used to develop novel approaches to the prevention and treatment of endometrial cancers.

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Joanna Groden, PhD

The Groden Laboratory has three primary areas of interest: the study of Bloom's syndrome, an inherited disorder that decreases chromosome stability and increases susceptibility to all types of cancer, the study of inherited disorders that increase susceptibility to colorectal cancer, especially

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Erich Grotewold, PhD

Dr. Grotewold's research focuses on the control of gene expression and architecture of regulatory networks, using transcription factors as tools for plant metabolic engineering, sub-cellular trafficking of phytochemicals and other small molecules.

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John Gunn, PhD

My laboratory performs research pertaining to microbial resistance to innate Immunity. Much of our research is focused on the macrophage, as well as the mucosal surface.

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Metin Gurcan, PhD

Dr. Gurcan's research interests include image analysis and understanding, computer vision with applications to medicine. Over the last decade, his research contributions have concentrated on computer-aided detection and diagnosis (CAD) of cancer.

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Tsonwin Hai, PhD

Maladaptation of cells to various signals plays important roles in the pathogenesis of many diseases. The current focus of my laboratory is to study the maladaptive processes in the development of breast cancer, melanoma, and diabetes.

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Heather Hampel, MS, CGC

Ms. Hampel's research interests include screening all colorectal and endometrial cancer patients for Lynch syndrome, the American Founder Mutation (exon 1-6 deletion in MSH2) as a cause of Lynch syndrome, and the etiology of MSI-negative familial colorectal cancers.

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Paul Herman, PhD

Dr. Herman's lab is interested in understanding the mechanisms Herman Lab Memberscontrolling eukaryotic cell growth and proliferation. The primary focus has been on the G0-like resting states that cells enter when conditions are not conducive to continued growth.

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F. Kay Huebner, PhD

The major focus of the laboratory is to thoroughly investigate and define the biological functions of the tumor suppressor proteins, Fhit and Wwox, encoded by the chromosome fragile sites FRA3B and FRA16D, two of the most frequently inactivated tumor suppressors in a broad spectrum of human

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Jaime Imitola, MD

Dr. Imitola directs the Neural Stem Cell Laboratory at the Department of Neurology, Ohio State University Wexner Medical Center. His research is focused on understanding the molecular mechanisms involving the cross talk between the immune system and neural stem cells genomics both in models of MS.

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Sissy Jhiang, PhD

Dr Jhiang current research interests are: (a) examine RET/PTC mediated signaling pathways in thyroid tumorigenesis and apply the finding to improve patients' care; (b) Investigate regulatory mechanisms of Na+/I- symporter(NIS) in thyroid cancer and breast cancer and apply the finding to develop

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Daniel Jones, MD, PhD

Dr. Jones' research interests center on models for mouse models, functional screens and classification approaches for attributing oncogenic and tumor potential of mutations identified in genomic screens and clinical sequencing assays. Specific model system are PTEN-haploinsufficient colon cancer.

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Lawrence Kirschner, MD, PhD

Dr. Kirschner's research is focused on endocrine tumor genetics, with specific interest in understanding how dysregulation of PKA contributes to tumorigenesis in cAMP-responsive tissues. Using a combination of in vivo mouse models and in vitro tissue culture work, his lab aims to understand how.

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Ashish Kumar, MD, PhD

Dr. Kumar's research studies the biology of infant-leukemia to identify novel therapeutic approaches to treat this disease. Infants with leukemia face an exceptionally grim prognosis because the pathogenesis of the disease is different than that seen in older children.

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Takeshi Kurita, PhD

Dr. Kurita's research interest lies in the molecular mechanisms of development and carcinogenesis of the reproductive organs. His lab mainly uses genetically engineered mouse models to investigate these research subjects.

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Nam Yong Lee, PhD

Dr. Lee's research focuses on how transforming growth factor beta (TGF beta) signaling regulates vascular functions during tumor development and metastasis. Dr. Lee's lab is particularly interested in understanding the role of two endothelial-specific TGF beta receptors, endoglin and ALK1, which.

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Jennifer Leight, PhD

The focus of research in the Leight lab is to utilize cutting edge biomaterials techniques to precisely vary the spatial and temporal presentation of 3D extracellular cues as well as develop new sensors to measure activity of specific members of the matrix metalloproteinase (MMP) family. Using.

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Stephen Lessnick, MD, PhD

As Director of the Center for Childhood Cancer and Blood Disorders at Nationwide Children's Hospital, Dr. Lessnick leads a team of pediatric researchers who are working to expand the understanding of the development of childhood cancer and to transform diagnostic and treatment strategies. He also.

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Zaibo Li, MD, PhD

Dr. Li specializes in breast pathology and GYN pathology. His interests are in breast cancer biomarkers, especially HER2 related testing, along with endometrial cancer, cervical cancer and cervical cancer screening programs..

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Q Richard Lu, PhD

Dr. Lu's lab has identified a novel tumor suppressor gene GNAS in medulloblastoma and defined an oncogenic role of Olig2 in glioma initiation and progression. Their research goal is to identify the critical molecules and pathways that drive tumorigenesis in glioblastoma and medulloblastoma, and.

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Thomas Ludwig, PhD

Dr. Ludwig's research focuses on biological function(s) of BRCA1 and BRCA2 and some of their interacting partners in normal and malignant development.

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K John McLaughlin, PhD

Dr. McLaughlin’s laboratory has current research interests in epigenetics, stem cells and therapeutic transplant models. They use mouse transplant models in which expression of imprinted genes is abnormal in the transplanted tissue.

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Wayne Miles, PhD

My research focuses on understanding how loss of the Retinoblastoma 1 (pRB) tumor suppressor changes the transcriptome and proteome of cancer cells.

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Jose Otero, MD, PhD

Dr. Otero's research interests include induced pluripotent stem cells, neural stem cells, cell cycle control of stem cells, and molecular diagnostics.

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Ioanna Papandreou, PhD

The dysfunctional tumor vasculature and the deregulated cancer cell proliferation create areas of oxygen- and nutrient- deprivation in solid tumors. Cells within the tumor respond to these microenvironmental stresses by activating adaptive mechanisms that allow malignant progression under such.

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Jeffrey Parvin, MD, PhD

Dr. Parvin's research involves the biological processes involved in breast cancer. His lab focuses on pathways regulated by the BRCA1 and BRCA2 tumor suppressor proteins, and these include the repair of DNA damage, control of transcription, control of cell cycle progression, and centrosome.

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Yuri Pekarsky, PhD

Mature T-cell leukemia commonly shows chromosomal rearrangements at 14q32. 1 including translocations t(14;14)(q11;q32), t(7;14)(q35;q32) and inversions inv(14)(q11;q32).

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John Phay, MD

Dr. Phay has two main research projects. The first is examining a novel AMPK activator for the treatment of thyroid cancer.

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Kamal Pohar, MD

Dr. Pohar’s research interest include: Bladder cancer, Testicular cancer, Genetic and epigenetic changes contributing to progression of bladder cancer, and Developing clinical and biologic databases in bladder cancer.

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Nancy Ratner, PhD

The long term interest of the Ratner laboratory is to define the interactions between glial cells and axons during nervous system development and how those interactions go awry in disease, with the goal of providing novel therapies to patients with nervous system diseases. Neurofibromatosis type.

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Eduardo Reategui, PhD

The Reátegui research group focuses on the development of microtechnology platforms for the isolation and characterization of circulating tumor biomarkers for cancer diagnostics and therapeutics. Circulating biomarkers are currently extensively studied in the cancer research field because of their.

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Grzegorz Rempala, PhD

Dr. Rempala's lab conducts high quality, original research in the areas of mathematical and applied statistics relevant to public health.

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Thomas Scharschmidt, MD

Thomas Scharschmidt, MD, is a member of the Molecular Biology and Cancer Genetics Program at OSUCCC – James, where his research focuses on adjuvant chemotherapy for management of soft tissue and bone sarcomas. He also investigates outcomes of limb reconstructions, oncology implant design.

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Daniel Schoenberg, PhD

The Schoenberg lab is nationally recognized for discoveries in fundamental mechanisms of post-transcriptional gene regulation and the application of this knowledge to signal transduction, cancer and inherited diseases. The four projects currently under study look at the molecular mechanisms of.

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Nilay Shah, MD

The primary interest of Dr. Shah’s lab is the set of aberrations that lead to embryonic cancers, i. e.

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Lawrence Shirley, MD, MS

Dr. Shirley is a surgical oncologist who researches the role of the protein integrin-linked kinase (ILK) in the progression of aggressive thyroid cancers. Dr. Shirley's lab is actively investigating the etiology for increased ILK expression in these fibroblasts, while also examining the role of.

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Amanda Simcox, PhD

Dr. Simcox studies EGF receptor signaling in the early wing disc. This simple system is about 30 cells in a just hatched larva and grows to about 150 cells in two days.

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Gina Sizemore, PhD

Research in the Sizemore lab integrates in vitro and in vivo modeling of the brain metastatic tumor microenvironment (TME) to provide mechanistic insight into how the brain metastatic TME contributes to breast cancer metastatic progression. Current studies aim to elucidate whether platelet derived.

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Steven Sizemore, PhD

Dr. Sizemore's research focuses on elucidating the mechanisms of cancer metastasis and developing novel therapies to improve outcomes for patients with metastatic disease. Metastatic breast cancer and metastatic soft tissue sarcoma are the areas of concentration for his research which combines.

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Jonathan Song, PhD

Dr. Song uses microscale engineering technology to reconstitute the microarchitecture of living tissue in vitro to systematically investigate how certain components of tumor microenvironment regulate angiogenesis. One of his research interests is understanding how the determinants of tumor blood.

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Anne Strohecker, PhD

Dr. Strohecker is interested in understanding how autophagy, a program that regulates protein and organelle quality control, impacts tumorigenesis. Her projects focus on (i) the identification of novel autophagy regulators and their functional relevance for lung tumorigenesis, and (ii) the role.

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Vish Subramaniam, PhD

The focus of Dr. Subramaniam’s research is on interactions between low frequency (< 1 MHz) electromagnetic waves and tissues and cells. This research ranges from fundamental studies to pre-clinical applications.

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Matthew Summers, PhD

Dr. Summers' research focuses on the mechanisms of genome maintenance, in particular understanding altered or heightened responses to stress occurring during replication or mitosis in transformed cells. His lab strives to gain novel insight into these differences in order to improve the treatment.

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Amanda Toland, PhD

Dr. Toland's lab is interested in identifying naturally occurring variations in genes that affect human cancer susceptibility in order to understand how tumors grow and develop, to identify new targets for cancer therapy and prevention, and to better define a person’s risk of getting cancer. An.

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Monica Venere, PhD

The overarching goal of Dr. Venere's laboratory is to elucidate points of fragility for glioblastoma using cell and molecular biology as well as animal models and exploit these findings to develop new treatment modalities and/or improve on current standard of care therapies and thereby alter

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Ruoning Wang, PhD

The fundamental interest of Dr. Wang's labe is to understand how eukaryotic cell integrates various extracellular and intrinsic signals/cues to dictate cellular fate (cell proliferation, death, growth and differentiation). In particular, we focus on understanding the impact of the interplay.

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Robin Wharton, PhD

We study post-transcriptional gene regulation during development in the germ line of the model system Drosophila melanogaster. Two proteins-- Nanos and Pumilio-- collaborate to repress translation of CyclinB mRNA in the primordial germ cells, thereby blocking proliferation.

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Terence Williams, MD, PhD

Dr. Williams' laboratory research interests center around lung and gastrointestinal (GI) malignancies. They are interested in the molecular biology and genetics of DNA repair and DNA damage response, those pathways which dictate tumor aggressiveness such as invasion and metastasis, and those.

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Jian-Qiu Wu, PhD

The goal of Dr. Wu's laboratory is to understand the roles of cytoskeletal and signaling proteins in cellular asymmetry and cell division in normal and cancer cells. We are focusing on the molecular mechanisms of cytokinesis in the fission yeast S.

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Li Wu, PhD

Dr. Wu's lab aims to better understand the mechanisms of epigenetic silencing of SAMHD1 in CTCL to develop novel therapeutic approaches. Our recent findings suggest that epigenetic silencing of SAMHD1 in malignant CD4+ T-cells contributes to uncontrolled T-cell growth in CTCL.

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Sung Yoon, PhD

Sung Yoon, PhD, is a member of the Molecular Biology and Cancer Genetics Program at OSUCCC – James, where her research focuses on understanding how the balance between cell survival and death is maintained in the adult nervous system. In particular, she is exploring the role of stress kinase JNK.

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Jacob Yount, PhD

Jacob Yount, PhD, is a member of the Molecular Biology and Cancer Genetics Program at OSUCCC – James, where his research focuses on developing and implementing tools to study protein post-translational modifications. In particular, he explores protein lipidations such as palmitoylation.

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Yan Zhang, PhD

High-throughput genomic and proteomic data has been and is being generated in cancer studies. My research interests span statistical and computational methods and their applications to genomic and proteomic research.

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Weiqiang Zhao, MD, PhD

Dr. Zhao's research interest include investigating and validating biomarkers in molecular pathogenesis, diagnosis, and target intervention in cancer and leukemia. One of his projects is to study the role of isoform 6 of IKZF1 gene in leukemia or lymphoma progression which has been shown to be.

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