Meet the leaders and members of the Molecular Carcinogenesis and Chemoprevention research program at the OSUCCC – James who focus on the molecular causes and prevention of cancer.

Leaders

Steven Clinton, MD, PhD

Dr. Clinton is a physician-scientist who divides his effort between clinical care and research. He serves as director of genitourinary oncology for The James and manages the renowned Prostate Cancer Multidisciplinary Clinic.

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Denis Guttridge, PhD

Dr. Guttridge's laboratory studies the NF-kB family of transcription factors and the role they play in cell growth and differentiation. The long-term goal is not only to better dissect the function and mechanisms by which NF-kB regulates muscle differentiation and turnover associated with muscle.

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Members

Samir Acharya, PhD

I am interested in deciphering the intersection of genomic stability and cellular growth/survival. Specifically, my research addresses the effects of DNA repair defects on nucleolar stress, and its manifestation in cellular growth and cellular transformation.

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Amit Agrawal, MD

Dr. Agrawal's specialty interests include head and neck oncology, facial plastic and reconstructive surgery.

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Michael Bailey, PhD

Dr. Bailey has a longstanding interest in understanding how commensal microbes impact immune system functioning, particularly during periods of endocrine activation. Studies from my laboratory, as well as others, indicate that gut microbes help to regulate the inflammatory response in both.

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Martha Belury, PhD

Dr. Belury and her lab are interested in the study of whole body energy metabolism as regulated by interactions between adipose and muscle tissues. Canonical mechanisms of energy metabolism involve insulin-dependent and –independent pathways in each of these tissues.

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Don Benson, MD, PhD

Our laboratory and clinical research programs seek to develop novel treatments for cancer that harness and enhance the immune system’s ability to detect and kill cancer cells. Natural killer cells, one type of immune cell in the body, are capable of killing cancer cells and much of the research.

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Richard Bruno, PhD, RD

The biochemical and molecular nutrition research conducted in Dr. Bruno’s laboratory aims to define the mechanisms regulating the bioavailability of dietary phytochemicals, particularly polyphenols such as quercetin and antioxidants including vitamin E, and the mechanisms by which these dietary

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Craig Burd, PhD

Dr. Burd's lab focuses on the signaling of estrogen through its cognate receptor, the estrogen receptor. Estrogen signaling plays a central role in breast cancer development and progression and deregulated activity influences therapeutic relapse.

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Moray Campbell, PhD

I have 20 years of experience in cancer research. My research addresses how and why transcription is distorted in prostate and breast cancer with the goal to exploit this understanding in diagnostic, prognostic and therapeutic settings.

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Ching-Shih Chen, PhD

Dr. Chen's research focuses on exploring signaling pathways that govern cancer cell survival as targets for drug discovery and design. He employs a multidisciplinary approach to identify new molecular targets by combining a wide range of expertise encompassing synthetic medicinal chemistry.

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Tong Chen, MD, PhD

Dr. Chen's interests include research in investigations of the mechanism(s) through which natural food products (i. e.

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Christopher Coss, PhD

Dr. Coss' research focuses on endocrine disease mechanisms and developing novel therapies for advanced prostate cancer. He also has an interest in chemoprevention of prostate and hepatocellular carcinomas using novel hormonal approaches.

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Zobeida Cruz-Monserrate, PhD

Pancreatic cancer is a deadly disease and obesity as a major risk factor. Nearly 30% of the world’s population is overweight or obese and rates continue to increase in adults and children.

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Robert Curley, Jr., PhD

Dr. Curley has a longstanding interest in the chemistry and biochemistry of the fat-soluble vitamins, particularly vitamin A, and their bioactive metabolites with a particular emphasis on their potential as cancer preventive and treatment agents.

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Robert DiSilvestro, PhD

Phytochemicals are food components from plants that are not strictly required for normal function, but can have health promoting properties. These health promoting properties can include reducing cancer risk.

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Andrea Doseff, PhD

Dr. Doseff's research explores various molecular and biochemical mechanisms that regulate cell death. Furthermore, her lab also concentrates on different signal transduction pathways that control apoptosis.

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Mark Failla, PhD

Dr. Failla and his research team are interested in the digestive stability, intestinal cell uptake, absorption, and functions of health-promoting compounds in foods. He primarily focuses on two families of compounds in plant foods, carotenoids and soy isoflavonoids.

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William Farrar, MD

Dr. Farrar's research interests include the study bioactive food components with cancer-preventative properties and to examine key epigenetic processes in order to begin to establish linkages between epigenetics, methylation patterns, and tumor incidences/behaviors.

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Avner Friedman, PhD

Dr. Friedman's research includes partial differential equations, mathematical biology, stochastic differential equations and control theory, particularly mathematical models of carcinogenesis and hormone therapy in prostate cancer.

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Gayle Gordillo, MD

Dr. Gordillo's team works on multiple different projects studying mechanisms regulating angiogenesis in both wound healing and endothelial cell tumor biology.

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Cassandra Grenade, MD

Dr. Grenade's research interest is in cancer disparities with a focus on improving cancer care and treatment to medically underserved populations. Dr. Grenade is part of the General Oncology-Outreach group and sees patients with all types of cancers at OSU East.

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Earl Harrison, PhD

Dr. Harrison’s laboratory studies the basic mechanisms involved in the intestinal absorption, transport, and metabolism of dietary vitamin A and carotenoids using cell culture, animal models, and investigations in human subjects. He is particularly interested in defining the proteins involved in.

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Hisham Hussan, MD

Dr. Hussan’s research interests include studying the effect of obesity, nutrition and microbiome on gastrointestinal neoplasia in order to devise preventive measures; the underlying mechanisms for the unexplained increasing incidence of sporadic colorectal cancer in patients less than age of 50,

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A. Douglas Kinghorn, PhD, DSc

Dr. Kinghorn has worked for about 30 years on the discovery of new anticancer agents from mainly tropical plants. For over a decade while at the University of Illinois at Chicago, Dr. Kinghorn served as Principal Investigator of a National Cooperative Drug Discovery Groups (NCDDG) project entitled.

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Thomas Knobloch, MS, PhD

Dr. Knobloch's interests include the mechanisms of molecular carcinogenesis and their interaction with food-based cancer risk reduction strategies following a "Bench to Bedside," "Crop to Clinic," and "Farm to Pharma" philosophy. Dr. Knobloch's work currently emphasizes the role of black raspberry.

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Somashekar Krishna, MD, MPH

Dr. Krishna's primary focus is in pancreatic malignancies. His research includes early diagnosis and diagnostic differentiation of pancreatic lesions, and specific role of endoscopic ultrasound (EUS).

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Purnima Kumar, PhD, DDS

Oral bacterial profiles associated with periodontal health and disease, including a) characterization of subgingival microbial profiles of periodontally healthy smokers and smokers with periodontitis, and b) the role of host genetics on oral bacterial colonization.

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Pui-Kai Li, PhD

The research area of Dr. Li focuses in the design, synthesis and biochemical testing of steroidal and non-steroidal steroid sulfatase inhibitors as potential agents for the treatment of hormone-dependent cancers.

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Young Lin, DVM, PhD

Dr. Lin's research projects are relevant to the human nutrition for chemoprevention and tumorigenesis of bio-active food component in human diets

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Susan Mallery, DDS, PhD

Dr. Mallery's research interests include Oral pathology, Oral cancer initiation; AIDS-related oral cancer; and chemoprevention

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Anjali Mishra, PhD

Dr. Mishra's research has shown stage-related ‘interleukin-15 (IL-15)’ mRNA and protein over-expression in lesional skin and circulating tumor cells of CTCL patients. Using IL-15 transgenic (tg) mice, Dr. Mishra's lab has characterized an animal model of spontaneous epidermotropic T-cell lymphoma.

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Amir Mortazavi, MD

Dr. Mortazavi's research interests include epigenetic modifications and experimental therapeutics for the prevention and treatment of genitourinary cancers.

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Tatiana Oberyszyn, PhD

Studies in the Oberyszyn skin carcinogenesis laboratory are designed to increase our understanding of the function of biological mediators including prostaglandins, cytokines and reactive oxygen intermediates during Ultraviolet Light induced Squamous Cell Carcinoma development. Current studies are.

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Steve Oghumu, PhD

Dr. Oghumu's research is focused on understanding the molecular mechanisms of oral carcinogenesis and black raspberry-mediated oral chemoprevention. His long-term goal is to identify discrete significant mediators of oral carcinogenesis that can be exploited in preventive and/or therapeutic.

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Dehua Pei, PhD

Dr. Pei's interest is in a variety of problems at the interface of chemistry and biology. A major area is to determine the molecular basis of biological processes by chemical methods.

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Harinantenaina Rakotondraibe, PhD

New natural product sources (new and unidentified fungal and bacterial microorganisms, plant endophytes, new endemic and medicinal plant species, etc. ) contain many undiscovered potential bioactive metabolites which can combat the world’s deadly diseases including cancer, malaria, viral.

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Kenneth Riedl, PhD

Dr. Riedl is a research scientist and associate director of the Nutrient & Phytochemical Analytic Shared Resource (NPASR) of the OSU-CCC. He provides method development and analysis expertise for nutrients, phytochemicals, their metabolites, and metabolomics experiments primarily for cancer.

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Kristen Roberts, PhD, RD, LD

Dr. Roberts’ research interests include biomedical research in nutrition, phytochemicals (namely ellagitannins), and cancer prevention. She has previously focused on the implementation of a black raspberry food product in men undergoing an elective prostatectomy for curative treatment of their.

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Thomas Rosol, DVM, PhD

Dr. Rosol's Laboratory is NCI and NCRR-funded to develop mouse models of human cancer with emphasis on bone metastasis, bone resorption and formation, and cancer-associated hypercalcemia. The molecular regulation of parathyroid hormone-related protein (PTHrP) is studied in vitro and in vivo using.

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Steven Schwartz, PhD

Steven Schwartz, PhD, is a member of the Molecular Carcinogenesis and Chemoprevention team at OSUCCC – James, where his research focuses on the health implications of food science, including metabolic profiling, significance of phytochemicals, bioactive components of food in cancer prevention and

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Chandan Sen, PhD

Dr. Sen’s program is interested in tissue injury and repair and works across three organ systems- skin, brain and heart. His group is interested in miRNA biology, redox signaling and tissue oxygenation.

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Colleen Spees, PhD, MEd, RDN, LD, FAND

Dr. Spees is an Assistant Professor in the Division of Medical Dietetics and Health Sciences in the School of Health and Rehabilitation Sciences College of Medicine with a focus on nutrition and cancer. Her laboratory research focuses on evaluating biomarkers of nutritional and dietary.

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Yael Vodovotz, PhD

Dr. Vodovotz' research is focused on the physico-chemical changes of functional foods during formulation, processing and storage as they impact the delivery of bioactives. Her lab utilizes molecular, structural and macroscopic analysis to fully characterize food material behavior in different.

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Qianben Wang, PhD

Dr. Wang's laboratory is interested in understanding the role of androgen receptor (AR) in the development and progression of prostate cancer. AR is a ligand-dependent transcription factor belonging to the nuclear hormone receptor (NR) superfamily.

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Qi-En Wang, PhD

The focus of Dr. Wang's research is on the regulation of nucleotide excision repair (NER), one of the DNA repair pathways, and the connection of DNA repair to cancer therapy. Dr. Wang's research strives to explore the mechanism of NER, and finally find means to prevent cancer initiation via.

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Altaf Wani, PhD

Dr. Wani's research interests include Molecular carcinogenesis-analysis, fine mapping and cellular processing of specific genotoxic base lesions, mutagenesis, apoptosis and other DNA damage responses.

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Christopher Weghorst, PhD

Christopher Weghorst, PhD, is a member of the Molecular Carcinogenesis and Chemoprevention Program at OSUCCC – James, where his work has earned him national recognition as a leader in molecular and comparative carcinogenesis research. In particular, he focuses on genetic susceptibility to.

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Mark Wewers, MD

Dr. Wewer’s research focuses on host defense against pathogens, particularly relevant to the lung and critical to survival His lab is interested in understanding the role of proteins that regulate the activation of the intracellular enzyme, caspase-1. This work is relevant to understanding how.

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Traci Wilgus, PhD

Dr. Wilgus studies the involvement of the pro-angiogenic growth factor vascular endothelial growth factor (VEGF) in skin carcinogenesis. VEGF is known to contribute to skin carcinogenesis by enhancing angiogenesis.

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Lisa Yee, MD

Lisa Yee, MD, is a member of the Molecular Carcinogenesis and Chemoprevention Program at OSUCCC – James, where her research focuses on gene-nutrient interactions affecting development and progression of breast cancer. In particular, she is investigating the mechanisms by which dietary fat.

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Jianhua Yu, PhD

Dr. Yu's research interests include Immuno-cellular therapy, blood and marrow transplantation, NK cell biology, gene regulation and cell signaling in immune response and malignant transformation

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Ouliana Ziouzenkova, PhD

Ouliana Ziouzenkova, PhD, is a member of the Molecular Carcinogenesis and Chemoprevention Program at OSUCCC – James, where her research focuses on how nutrients regulate genes and can prevent metabolic diseases. One of her recent studies highlights a mechanism by which an enzyme in vitamin A.

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