Meet the leaders and members of the Molecular Carcinogenesis and Chemoprevention research program at the OSUCCC – James who focus on the molecular causes and prevention of cancer.

Leaders

Steven Clinton, MD, PhD

Steven Clinton, MD, PhD, is a professor in the Division of Medical Oncology and the Department of Urology at The Ohio State University, where he also leads the Molecular Carcinogenesis and Chemoprevention Program at the OSUCCC – James. He is a physician-scientist who divides his effort.

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Members

Olorunfemi Adetona, PhD

As a member of the Molecular Carcinogenesis and Chemoprevention Program at the OSUCCC – James, Olorunfemi Adetona, PhD, focuses his research on investigating the relationship between exposures to combustion-derived air pollution and cancer risk. Dr. Adetona is conducting a study to.

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Amit Agrawal, MD

Dr. Agrawal's specialty interests include head and neck oncology, facial plastic and reconstructive surgery.

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Michael Bailey, PhD

Michael Bailey, PhD, is a member of the Molecular Carcinogenesis and Chemoprevention Program at the OSUCCC – James. He brings a special perspective as an associate professor in the Division of Biosciences at The Ohio State University College of Dentistry.

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Martha Belury, PhD

Dr. Belury and her lab are interested in the study of whole body energy metabolism as regulated by interactions between adipose and muscle tissues. Canonical mechanisms of energy metabolism involve insulin-dependent and –independent pathways in each of these tissues.

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Don Benson, MD, PhD

Don Benson Jr. , MD PhD, FACP, is a member of the Molecular Carcinogenesis and Chemoprevention Program at the OSUCCC – James, where he and his multidisciplinary, subspecialized team care for patients with multiple myeloma and amyloidosis, as well as those undergoing blood and marrow stem cell.

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Richard Bruno, PhD, RD

Richard Bruno, PhD, RD, brings a unique “foods-first” perspective to the Molecular Carcinogenesis and Chemoprevention team at the OSUCCC – James, as he is based in the Human Nutrition program located in the College of Education and Human Ecology. His research uses biochemical and molecular.

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Christin Burd, PhD

Christin Burd, PhD, is a member of the Molecular Carcinogenesis and Chemoprevention Program at the OSUCCC – James, where she focuses her research on improving our understanding of the connections between cancer and aging. Her team’s goal is to bridge bench science and clinical trials.

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Craig Burd, PhD

Craig Burd, PhD, is a member of the Molecular Carcinogenesis and Chemoprevention Program at the OSUCCC – James. His work explores the molecular mechanisms controlling estrogen signaling and how, when not properly maintained, these mechanisms may influence breast cancer risk and therapeutic.

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Moray Campbell, PhD

Moray Campbell, PhD, is a member of the Molecular Carcinogenesis and Chemoprevention Program at the OSUCCC – James, where his research explores the distortion of transcription in prostate and breast cancer to improve diagnosis, prognosis and therapeutics. Specifically, he focuses on nuclear.

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Lei Cao, PhD

Lei Cao, PhD, is a member of the Molecular Carcinogenesis and Chemoprevention Program at the OSUCCC – James. Dr. Cao’s research has characterized a novel brain-fat axis underlying the antiobesity and anticancer phenotypes involved in a complex environment.

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Tong Chen, MD, PhD

Tong Chen, MD, PhD, is a member of the Molecular Carcinogenesis and Chemoprevention Program at the OSUCCC – James. She is a physician-scientist and believes that cancer chemoprevention is a cornerstone of cancer control.

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Jessica Cooperstone, PhD

Jessica Cooperstone, Ph. D.

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Christopher Coss, PhD

Christopher Coss, PhD, is a member of the Molecular Carcinogenesis and Chemoprevention Program at the OSUCCC – James, where he brings a therapeutics perspective. His research focuses on cachexia therapeutics, endocrine-disease mechanisms and development of novel therapies for endocrine.

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Zobeida Cruz-Monserrate, PhD

Pancreatic cancer is a deadly disease and obesity is a major risk factor. Nearly 30% of the world’s population is overweight or obese, and rates continue to increase in adults and children.

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Purnima Dubey, PhD

Dr. Dubey's lab studies the effect of castration on the immune microenvironment of prostate cancer. Using endogenous murine models of prostate cancer, we showed that castration promotes the recruitment and function of suppressive neutrophils and Tregs that promote castration-resistant prostate.

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William Farrar, MD

William Farrar, MD, is a surgical oncologist who serves as CEO of The James Cancer Hospital and Solove Research Institute and as director of the Stefanie Spielman Comprehensive Breast Cancer. Dr. Farrar has been on the medical staff at The James since the hospital opened in 1990.

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Richard Fishel, PhD

Dr Fishel’s research interests includes DNA Repair defects and Genomic Instability in cancer development; biophysical chemistry of DNA repair; and single molecule imaging in vitro and in vivo. His laboratory studies the mechanisms, genetics, regulation, and consequences of DNA repair and genome.

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Avner Friedman, PhD

Avner Friedman, PhD, is a Distinguished University Professor in the Department of Mathematics at Ohio State, where he also was the founding director of the Mathematical Biosciences Institute (MBI). As a mathematician, Dr. Friedman brings a singular perspective to his research in the Molecular.

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Paul Goodfellow, PhD

The research of Paul Goodfellow, PhD, a professor in the Department of Obstetrics and Gynecology at Ohio State and a member of the OSUCCC – James Molecular Carcinogenesis and Chemoprevention Program, centers on understanding the role that loss of DNA-mismatch repair plays in uterine tumor

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Heather Hampel, MS, LGC

Heather Hampel, MS, LGC, is a professor and associate director of the Division of Human Genetics at Ohio State, and a member of the Molecular Carcinogenesis and Chemoprevention Program at the OSUCCC – James, where she also serves as associate director for biospecimen research. Ms. Hampel’s.

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Earl Harrison, PhD

Earl Harrison, PhD, Dean’s Distinguished Professor in the Department of Human Sciences at Ohio State, is a member of the Molecular Carcinogenesis and Chemoprevention Program at the OSUCCC – James, where his research focuses on vitamin A and its intestinal absorption, transport and metabolism.

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Amanda Hummon, PhD

Dr. Hummon's research interests lie at the intersection of analytical chemistry and chemical biology, with a focus on cancer biology. Her lab develops analytical methods to evaluate the proteome, phosphoproteome and metabolome in cancer cells, while exploring the deregulation in cancer-associated.

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Hisham Hussan, MD

Dr. Hussan’s research interests include studying the effect of obesity, nutrition and microbiome on gastrointestinal neoplasia in order to devise preventive measures; the underlying mechanisms for the unexplained increasing incidence of sporadic colorectal cancer in patients less than age of 50,

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Rishi Jain, MD, MS

Questions regarding the importance of nutrition and its relationship with cancer are commonly encountered in the oncology clinic. I have always taken a special interest in understanding the impact of nutritional status as a modifiable risk factor in various cancers.

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A. Douglas Kinghorn, PhD, DSc

A. Douglas Kinghorn, PhD, DSc, is a member of the Molecular Carcinogenesis and Chemoprevention Program at the OSUCCC – James, where his current research focuses on the discovery of new anticancer agents, primarily from tropical plants.

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Thomas Knobloch, MS, PhD

Thomas Knobloch, MS, PhD, is a member of the Molecular Carcinogenesis and Chemoprevention Program at the OSUCCC – James, where his research focuses on molecular carcinogenesis and its interaction with food-based, cancer risk reduction strategies. In particular, his work follows a.

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Rachel Kopec, PhD

Rachel Kopec is an assistant professor of human nutrition in the Department of Human Sciences. Her team uses analytical chemistry tools and metabolomics techniques (i.

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Somashekar Krishna, MD, MPH

Dr. Krishna's primary focus is in pancreatic malignancies. His research includes early diagnosis and diagnostic differentiation of pancreatic lesions, and specific role of endoscopic ultrasound (EUS).

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Samuel Kulp, PhD

Samuel Kulp, DVM, PhD, is a member of the Molecular Carcinogenesis and Chemoprevention Program at the OSUCCC – James. As a research scientist in The Ohio State University College of Pharmacy, Division of Medicinal Chemistry and Pharmacognosy, Dr. Kulp is part of a multidisciplinary.

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Purnima Kumar, PhD, DDS

Purnima Kumar, PhD, DDS, is a member of the Molecular Carcinogenesis and Chemoprevention Program at the OSUCCC – James, where her research focuses on oral bacterial profiles. In particular, Dr. Kumar is researching the role of host genetics on oral bacterial colonization and characterizing.

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Jiyoung Lee, PhD

The main theme of my research is discovering microbial contamination in the nexus of water-food-environments and its linkage to health outcomes in multi-temporal and spatial scales. Much of my recent research has focused on emerging pathways of cancer-promoting cyanotoxin exposure and its linkage.

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Pui-Kai Li, PhD

Pui-Kai Li, PhD, is a member of the Molecular Carcinogenesis and Chemoprevention Program at the OSUCCC – James, where he brings a pharmacological perspective. His research explores the design, synthesis and biochemical testing of sulfatase inhibitors as possible agents in treatment of.

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Susan Mallery, DDS, PhD

Susan Mallery, DDS, PhD, is a member of the Molecular Carcinogenesis and Chemoprevention Program at the OSUCCC – James, where her research focuses on oral pathology, oral cancer initiation and chemoprevention. She also studies AIDS-related oral cancer.

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Maria Mihaylova, PhD

Dr. Mihaylova is interested in understanding the effects of diet and aging on cellular metabolism. It is now appreciated that organismal and cellular metabolism can become deregulated with age, which can potentially accelerate cancer initiation or progression.

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Darrion Mitchell, MD, PhD

My over-arching interests involve improving prognostic, diagnostic, and treatment responses in head and neck cancer and prostate cancer. My initial focus will be on HPV negative head and neck cancer and the development of new selective therapy either natural or pharmacologically created that will.

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Amir Mortazavi, MD

Amir Mortazavi, MD, is a member of the Molecular Carcinogenesis and Chemoprevention Program at the OSUCCC – James, where his research focuses on epigenetic modifications and experimental therapeutics for genitourinary cancers. One of his recent research projects suggests that sorafenib, an oral.

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Tatiana Oberyszyn, PhD

Tatiana Oberyszyn, PhD, is a member of the Molecular Carcinogenesis and Chemoprevention Program at the OSUCCC – James, where her research focuses on understanding the process of ultraviolet (UV) light-induced squamous cell carcinoma development. In particular, she is interested in how mediators.

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Steve Oghumu, PhD

Steve Oghumu, PhD, is a member of the Molecular Carcinogenesis and Chemoprevention Program at the OSUCCC – James, where his research focuses on the molecular mechanisms of oral carcinogenesis and black raspberry-mediated oral chemoprevention. He seeks to identify discrete significant mediators.

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Dehua Pei, PhD

Dehua Pei, PhD, is a member of the Molecular Carcinogenesis and Chemoprevention Program at the OSUCCC – James, where his research focuses on the molecular basis of biological processes by chemical methods. In particular, he seeks to identify the interaction partners of protein modular domains.

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Harinantenaina Rakotondraibe, PhD

Harinantenaina Rakotondraibe, PhD, is a member of the Molecular Carcinogenesis and Chemoprevention Program at the OSUCCC – James, where he focuses his research on the role of new natural product sources in potential bioactive metabolites to combat cancer, chemoresistance and more. In.

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Kenneth Riedl, PhD

Kenneth Riedl, PhD, is a member of the Molecular Carcinogenesis and Chemoprevention Program at the OSUCCC – James, where he also serves as associate director of the Nutrient & Phytochemical Analytic Shared Resource. His research focuses on analyzing nutrients, phytochemicals and their.

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Kristen Roberts, PhD, RD

Dr. Roberts’ research interests include biomedical research in nutrition, phytochemicals (namely ellagitannins), and cancer prevention. She has previously focused on the implementation of a black raspberry food product in men undergoing an elective prostatectomy for curative treatment of their.

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Zachary Schultz, PhD

My laboratory develops instrumentation for the detection biomolecules and characterization of biological samples. We are currently funded by NCI to develop a new method for detecting changes in oncometabolites from tumors.

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Heather Shive, DVM, PhD

Dr. Shive uses the zebrafish model to analyze novel genes expressed in cancer and microenvironmental cells that promote cancer progression in the context of BRCA2 and TP53 mutations. She generated the first zebrafish model for BRCA2 mutation and identified key effects on development.

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Daniel Spakowicz, PhD

Daniel Spakowicz, PhD, is a research assistant professor in the Division of Medical Oncology at Ohio State and a member of the Molecular Carcinogenesis and Chemoprevention Program at the OSUCCC – James. His lab studies the role of the microbiome in human health, particularly the immunomodulatory.

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Colleen Spees, PhD, RD

As a member of the Molecular Carcinogenesis and Chemoprevention Program at the OSUCCC – James, Collen Spees, PhD, RD, focuses on nutritional genomics and cancer. In 2011, she established The Ohio State University’s first nutritional genomics graduate course.

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Fred Tabung, PhD, MSPH

Fred Tabung, PhD, MSPH, is an assistant professor in the Department of Internal Medicine at Ohio State and a member of the Molecular Carcinogenesis and Chemoprevention Program at the OSUCCC – James, where his research focuses on the role of diet and lifestyle in cancer risk and survival,

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Amanda Toland, PhD

Amanda Toland, PhD, is a member of the Molecular Carcinogenesis and Chemoprevention Program at the OSUCCC – James, where her research focuses on identifying naturally occurring gene variations that affect cancer susceptibility, as well as mutations that drive tumors, in order to better prevent

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Yael Vodovotz, PhD

Yael Vodovotz, PhD, is a member of the Molecular Carcinogenesis and Chemoprevention Program at the OSUCCC – James, where her research focuses on the chemical changes of functional foods in bioactives delivery. In particular, she uses molecular, structural and macroscopic analysis to.

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Qi-En Wang, PhD

Qi-En Wang, PhD, is a member of the Molecular Carcinogenesis and Chemoprevention Program at the OSUCCC – James, where he focuses his research on the regulation of the DNA repair pathway nucleotide excision repair and its connection to cancer therapy. In particular, he seeks to understand DNA.

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Altaf Wani, PhD

Altaf Wani, PhD, is a member of the Molecular Carcinogenesis and Chemoprevention Program at the OSUCCC – James, where his research focuses on molecular carcinogenesis analysis, fine mapping and cellular processing of DNA damage responses. One of his recent studies revealed an unappreciated.

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Christopher Weghorst, PhD

Christopher Weghorst, PhD, is a member of the Molecular Carcinogenesis and Chemoprevention Program at OSUCCC – James, where his work has earned him national recognition as a leader in molecular and comparative carcinogenesis research. In particular, he focuses on genetic susceptibility to.

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Haitao Wen, MD, PhD

A hallmark feature of colorectal cancer (CRC) is enhanced activation of immune signaling and inflammatory cytokine production. Recent studies have established that activated immune cells and cancer cells exhibit similar reprogramming process in glucose metabolism.

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Mark Wewers, MD

Mark Wewers, MD, is a member of the Molecular Carcinogenesis and Chemoprevention Program at the OSUCCC – James, where his research focuses on host defense against pathogens. In particular, he seeks to understand how the lung and circulating mononuclear phagocytes sense danger from pathogens and.

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Traci Wilgus, PhD

Traci Wilgus, PhD, is a member of the Molecular Carcinogenesis and Chemoprevention Program at the OSUCCC – James, where her research focuses on the pro-angiogenic vascular endothelial growth factor (VEGF) in skin carcinogenesis. Her research has revealed that VEGFR-1 is expressed by.

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Vicki Wysocki, PhD

Vicki Wysocki, PhD, is a member of the Molecular Carcinogenesis and Chemoprevention Program at the OSUCCC – James, where she focuses on the development of mass spectrometry (MS)-based metabolomics and proteomics tools in support of cancer research. Dr. Wysocki’s research is separated into three.

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Kristine Yoder, PhD

DNA repair proteins are central to cancer transformation and progression. The Yoder lab is studying the interactions of host DNA repair proteins and their interactions with HIV cDNA.

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Jiangjiang (Chris) Zhu, PhD

Chris Zhu, PhD, is an assistant professor in the Department of Human Sciences at The Ohio State University and a member of the Molecular Carcinogenesis and Chemoprevention Program at the OSUCCC – James, where he specializes in metabolomics studies for cancer. Dr. Zhu’s current research includes.

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Ouliana Ziouzenkova, PhD

Ouliana Ziouzenkova, PhD, is a member of the Molecular Carcinogenesis and Chemoprevention Program at OSUCCC – James, where her research focuses on how nutrients regulate genes and can prevent metabolic diseases. One of her recent studies highlights a mechanism by which an enzyme in vitamin A.

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