Meet the leaders and members of the Molecular Carcinogenesis and Chemoprevention research program at the OSUCCC – James who focus on the molecular causes and prevention of cancer.

Leaders

Steven Clinton, MD, PhD

Dr. Clinton is a physician-scientist who divides his effort between clinical care and research. He serves as director of genitourinary oncology for The James and manages the renowned Prostate Cancer Multidisciplinary Clinic.

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Members

Samir Acharya, PhD

Samir Acharya, PhD, is a member of the Molecular Carcinogenesis and Chemoprevention Program at the OSUCCC – James, where his research focuses on deciphering the intersection of genomic stability and cell growth/survival to develop strategies to prevent tumor growth. In particular, he explores.

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Amit Agrawal, MD

Dr. Agrawal's specialty interests include head and neck oncology, facial plastic and reconstructive surgery.

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Michael Bailey, PhD

Michael Bailey, PhD, is a member of the Molecular Carcinogenesis and Chemoprevention Program at the OSUCCC – James. He brings a special perspective as an associate professor in the Division of Biosciences at The Ohio State University College of Dentistry.

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Martha Belury, PhD

Dr. Belury and her lab are interested in the study of whole body energy metabolism as regulated by interactions between adipose and muscle tissues. Canonical mechanisms of energy metabolism involve insulin-dependent and –independent pathways in each of these tissues.

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Don Benson, MD, PhD

Don Benson Jr. , MD PhD, FACP, is a member of the Molecular Carcinogenesis and Chemoprevention Program at the OSUCCC – James, where he and his multidisciplinary, subspecialized team care for patients with multiple myeloma and amyloidosis, as well as those undergoing blood and marrow stem cell.

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Richard Bruno, PhD, RD

Richard Bruno, PhD, RD, brings a unique “foods-first” perspective to the Molecular Carcinogenesis and Chemoprevention team at the OSUCCC – James, as he is based in the Human Nutrition program located in the College of Education and Human Ecology. His research uses biochemical and molecular.

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Craig Burd, PhD

Craig Burd, PhD, is a member of the Molecular Carcinogenesis and Chemoprevention Program at the OSUCCC – James. His work explores the molecular mechanisms controlling estrogen signaling and how, when not properly maintained, these mechanisms may influence breast cancer risk and therapeutic.

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Moray Campbell, PhD

Moray Campbell, PhD, is a member of the Molecular Carcinogenesis and Chemoprevention Program at the OSUCCC – James, where his research explores the distortion of transcription in prostate and breast cancer to improve diagnosis, prognosis and therapeutics. Specifically, he focuses on nuclear.

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Tong Chen, MD, PhD

Tong Chen, MD, PhD, is a member of the Molecular Carcinogenesis and Chemoprevention Program at the OSUCCC – James. She is a physician-scientist and believes that cancer chemoprevention is a cornerstone of cancer control.

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Jessica Cooperstone, PhD

Jessica Cooperstone, Ph. D.

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Christopher Coss, PhD

Christopher Coss, PhD, is a member of the Molecular Carcinogenesis and Chemoprevention Program at the OSUCCC – James, where he brings a therapeutics perspective. His research focuses on cachexia therapeutics, endocrine-disease mechanisms and development of novel therapies for endocrine.

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Zobeida Cruz-Monserrate, PhD

Pancreatic cancer is a deadly disease and obesity as a major risk factor. Nearly 30% of the world’s population is overweight or obese and rates continue to increase in adults and children.

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Robert DiSilvestro, PhD

Phytochemicals are food components from plants that are not strictly required for normal function, but can have health promoting properties. These health promoting properties can include reducing cancer risk.

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Purnima Dubey, PhD

Dr. Dubey's lab studies the effect of castration on the immune microenvironment of prostate cancer. Using endogenous murine models of prostate cancer, we showed that castration promotes the recruitment and function of suppressive neutrophils and Tregs that promote castration-resistant prostate.

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William Farrar, MD

William Farrar, MD, is a surgical oncologist who serves as interim CEO of The James Cancer Hospital and Solove Research Institute and as director of the Stefanie Spielman Comprehensive Breast Cancer. Dr. Farrar has been on the medical staff at The James since the hospital opened in 1990.

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Avner Friedman, PhD

Avner Friedman, PhD, is a Distinguished University Professor in the Department of Mathematics at Ohio State, where he also was the founding director of the Mathematical Biosciences Institute (MBI). As a mathematician, Dr. Friedman brings a singular perspective to his research in the Molecular.

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Gayle Gordillo, MD

Gayle Gordillo, MD, is an associate professor in the Department of Plastic Surgery at Ohio State and a member of the Molecular Carcinogenesis and Chemoprevention Program at the OSUCCC – James, where she focuses her research on the mechanisms regulating the formation of blood vessels in endothelial

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Cassandra Grenade, MD

Cassandra Grenade, MD, is an assistant professor in the Division of Hematology at Ohio State and a member of the Molecular Carcinogenesis and Chemoprevention Program at the OSUCCC – James. Her research focuses on cancer disparities with the intent to improve care and treatment for medically.

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Earl Harrison, PhD

Earl Harrison, PhD, Dean’s Distinguished Professor in the Department of Human Sciences at Ohio State, is a member of the Molecular Carcinogenesis and Chemoprevention Program at the OSUCCC – James, where his research focuses on vitamin A and its intestinal absorption, transport and metabolism.

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Amanda Hummon, PhD

Dr. Hummon's research interests lie at the intersection of analytical chemistry and chemical biology, with a focus on cancer biology. Her lab develops analytical methods to evaluate the proteome, phosphoproteome and metabolome in cancer cells, while exploring the deregulation in cancer-associated.

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Hisham Hussan, MD

Dr. Hussan’s research interests include studying the effect of obesity, nutrition and microbiome on gastrointestinal neoplasia in order to devise preventive measures; the underlying mechanisms for the unexplained increasing incidence of sporadic colorectal cancer in patients less than age of 50,

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Rishi Jain, MD, MS

Questions regarding the importance of nutrition and its relationship with cancer are commonly encountered in the oncology clinic. I have always taken a special interest in understanding the impact of nutritional status as a modifiable risk factor in various cancers.

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A. Douglas Kinghorn, PhD, DSc

A. Douglas Kinghorn, PhD, DSc, is a member of the Molecular Carcinogenesis and Chemoprevention Program at the OSUCCC – James, where his current research focuses on the discovery of new anticancer agents, primarily from tropical plants.

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Thomas Knobloch, MS, PhD

Thomas Knobloch, MS, PhD, is a member of the Molecular Carcinogenesis and Chemoprevention Program at the OSUCCC – James, where his research focuses on molecular carcinogenesis and its interaction with food-based, cancer risk reduction strategies. In particular, his work follows a.

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Somashekar Krishna, MD, MPH

Dr. Krishna's primary focus is in pancreatic malignancies. His research includes early diagnosis and diagnostic differentiation of pancreatic lesions, and specific role of endoscopic ultrasound (EUS).

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Samuel Kulp, PhD

Samuel Kulp, DVM, PhD, is a member of the Molecular Carcinogenesis and Chemoprevention Program at the OSUCCC – James. As a research scientist in The Ohio State University College of Pharmacy, Division of Medicinal Chemistry and Pharmacognosy, Dr. Kulp is part of a multidisciplinary.

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Purnima Kumar, PhD, DDS

Purnima Kumar, PhD, DDS, is a member of the Molecular Carcinogenesis and Chemoprevention Program at the OSUCCC – James, where her research focuses on oral bacterial profiles. In particular, Dr. Kumar is researching the role of host genetics on oral bacterial colonization and characterizing.

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Pui-Kai Li, PhD

The research area of Dr. Li focuses in the design, synthesis and biochemical testing of steroidal and non-steroidal steroid sulfatase inhibitors as potential agents for the treatment of hormone-dependent cancers.

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Young Lin, DVM, PhD

Dr. Lin's research projects are relevant to the human nutrition for chemoprevention and tumorigenesis of bio-active food component in human diets

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Susan Mallery, DDS, PhD

Dr. Mallery's research interests include Oral pathology, Oral cancer initiation; AIDS-related oral cancer; and chemoprevention

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Anjali Mishra, PhD

Dr. Mishra's research has shown stage-related ‘interleukin-15 (IL-15)’ mRNA and protein over-expression in lesional skin and circulating tumor cells of CTCL patients. Using IL-15 transgenic (tg) mice, Dr. Mishra's lab has characterized an animal model of spontaneous epidermotropic T-cell lymphoma.

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Darrion Mitchell, MD, PhD

My over-arching interests involve improving prognostic, diagnostic, and treatment responses in head and neck cancer and prostate cancer. My initial focus will be on HPV negative head and neck cancer and the development of new selective therapy either natural or pharmacologically created that will.

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Amir Mortazavi, MD

Dr. Mortazavi's research interests include epigenetic modifications and experimental therapeutics for the prevention and treatment of genitourinary cancers.

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Tatiana Oberyszyn, PhD

Studies in the Oberyszyn skin carcinogenesis laboratory are designed to increase our understanding of the function of biological mediators including prostaglandins, cytokines and reactive oxygen intermediates during Ultraviolet Light induced Squamous Cell Carcinoma development. Current studies are.

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Steve Oghumu, PhD

Dr. Oghumu's research is focused on understanding the molecular mechanisms of oral carcinogenesis and black raspberry-mediated oral chemoprevention. His long-term goal is to identify discrete significant mediators of oral carcinogenesis that can be exploited in preventive and/or therapeutic.

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Dehua Pei, PhD

Dr. Pei's interest is in a variety of problems at the interface of chemistry and biology. A major area is to determine the molecular basis of biological processes by chemical methods.

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Harinantenaina Rakotondraibe, PhD

New natural product sources (new and unidentified fungal and bacterial microorganisms, plant endophytes, new endemic and medicinal plant species, etc. ) contain many undiscovered potential bioactive metabolites which can combat the world’s deadly diseases including cancer, malaria, viral.

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Kenneth Riedl, PhD

Dr. Riedl is a research scientist and associate director of the Nutrient & Phytochemical Analytic Shared Resource (NPASR) of the OSU-CCC. He provides method development and analysis expertise for nutrients, phytochemicals, their metabolites, and metabolomics experiments primarily for cancer.

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Kristen Roberts, PhD, RD, LD

Dr. Roberts’ research interests include biomedical research in nutrition, phytochemicals (namely ellagitannins), and cancer prevention. She has previously focused on the implementation of a black raspberry food product in men undergoing an elective prostatectomy for curative treatment of their.

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Zachary Schultz, PhD

My laboratory develops instrumentation for the detection biomolecules and characterization of biological samples. We are currently funded by NCI to develop a new method for detecting changes in oncometabolites from tumors.

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Daniel Spakowicz, PhD

Daniel Spakowicz, PhD, is a research assistant professor in the Division of Medical Oncology at Ohio State and a member of the Molecular Carcinogenesis and Chemoprevention Program at the OSUCCC – James. His lab studies the role of the microbiome in human health, particularly the immunomodulatory.

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Colleen Spees, PhD, MEd, RDN, LD, FAND

Dr. Spees is an Assistant Professor in the Division of Medical Dietetics and Health Sciences in the School of Health and Rehabilitation Sciences College of Medicine with a focus on nutrition and cancer. Her laboratory research focuses on evaluating biomarkers of nutritional and dietary.

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Fred Tabung, PhD, MSPH

Fred Tabung, PhD, MSPH, is an assistant professor in the Department of Internal Medicine at Ohio State and a member of the Molecular Carcinogenesis and Chemoprevention Program at the OSUCCC – James, where his research focuses on the role of diet and lifestyle in cancer risk and survival,

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Yael Vodovotz, PhD

Dr. Vodovotz' research is focused on the physico-chemical changes of functional foods during formulation, processing and storage as they impact the delivery of bioactives. Her lab utilizes molecular, structural and macroscopic analysis to fully characterize food material behavior in different.

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Qi-En Wang, PhD

Qi-En Wang, PhD, focuses his current research interests on cancer stem cell biology, DNA repair and chemotherapy resistance. He is particularly interested in investigating the DNA damage responses after cisplatin and PARP inhibitor treatment in ovarian cancer, the impact of DNA damage responses on.

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Altaf Wani, PhD

Dr. Wani's research interests include Molecular carcinogenesis-analysis, fine mapping and cellular processing of specific genotoxic base lesions, mutagenesis, apoptosis and other DNA damage responses.

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Christopher Weghorst, PhD

Christopher Weghorst, PhD, is a member of the Molecular Carcinogenesis and Chemoprevention Program at OSUCCC – James, where his work has earned him national recognition as a leader in molecular and comparative carcinogenesis research. In particular, he focuses on genetic susceptibility to.

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Haitao Wen, PhD

A hallmark feature of colorectal cancer (CRC) is enhanced activation of immune signaling and inflammatory cytokine production. Recent studies have established that activated immune cells and cancer cells exhibit similar reprogramming process in glucose metabolism.

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Mark Wewers, MD

Dr. Wewer’s research focuses on host defense against pathogens, particularly relevant to the lung and critical to survival His lab is interested in understanding the role of proteins that regulate the activation of the intracellular enzyme, caspase-1. This work is relevant to understanding how.

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Traci Wilgus, PhD

Dr. Wilgus studies the involvement of the pro-angiogenic growth factor vascular endothelial growth factor (VEGF) in skin carcinogenesis. VEGF is known to contribute to skin carcinogenesis by enhancing angiogenesis.

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Ouliana Ziouzenkova, PhD

Ouliana Ziouzenkova, PhD, is a member of the Molecular Carcinogenesis and Chemoprevention Program at OSUCCC – James, where her research focuses on how nutrients regulate genes and can prevent metabolic diseases. One of her recent studies highlights a mechanism by which an enzyme in vitamin A.

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