Expertise

The CPMPSR is located in Ohio State’s College of Veterinary Medicine and has access to veterinary pathology expertise from 14 board certified veterinary pathologists in the Department of Veterinary Biosciences. Additional expertise is available to CPMPSR clients by veterinary radiologists, ophthalmologists and cardiologists in the College of Veterinary Medicine.

  • CPMPSR Director: Krista M.D. La Perle, DVM, PhD, Dipl. ACVP

  • PMPSR Associate Director: Sue E. Knoblaugh, DVM, Dipl. ACVP

  • CPMPSR Comparative Pathologist: Kara N. Corps, DVM, PhD, Dipl. ACVP

  • Medical Laboratory Technologist:Janae' DuLaney, BS, MLS (ASCP)

  • Research Assistant: Julie Rectenwald, AHT, MLT

  • Lab Demonstrator (virtual microscopy): Jenny Bolon, RVT

  • Histology/Immunohistochemistry Laboratory Manager: David Hart, BS, HT (ASCP)

  • Histotechnologist: Chelssie Breece, BS, HTL (ASCP)

  • Histotechnologist: Tessa VerStraete, AA, BS

  • Immunohistotechnician: Brenda Wilson

Krista M.D. La Perle, DVM, PhD, Dipl. ACVP, is the CPMPSR director and a professor at The Ohio State University. As CPMPSR director, Dr. La Perle oversees all CPMPSR operations and projects, including pre-submission consultations, macroscopic lesion interpretation, histologic tissue evaluation, clinical pathology data interpretation and final report preparation. She also meets with investigative staff to discuss findings, demonstrate pertinent lesions, recommend ancillary tests and plan subsequent studies. Dr. La Perle has over 20 years of experience evaluating pathology in various species of animals, including genetically engineered and immunodeficient rodents as well as non-rodent models and preclinical toxicity and efficacy studies for device/drug/biologic development. She completed her postdoctoral training in veterinary anatomic pathology at Ohio State and is board certified by the American College of Veterinary Pathologists. She earned her DVM from North Carolina State University and her PhD in Experimental and Molecular Pathology from Ohio State University, where her National Institutes of Health-funded research focused on animal models of thyroid cancer and developing gene therapy strategies of sodium/iodide symporter-mediated radionuclide imaging and therapy for cancer. Prior to her position as the CPMPSR director, Dr. La Perle established the Genetically Engineered Mouse Phenotyping Service and was director of the Laboratory of Comparative Pathology for Memorial Sloan-Kettering Cancer Center, Weill Medical College of Cornell University and Rockefeller University in New York City.

Sue E. Knoblaugh, DVM, Dipl. ACVP, is the CPMPSR associate director and an associate professor at The Ohio State University. Dr. Knoblaugh is a board certified veterinary pathologist with expertise in mouse pathology. She has considerable experience with genetically modified mice and the use of mouse models in the translational study of human disease, particularly models of inflammation, infectious disease and cancer. She earned her DVM degree from the College of Veterinary Medicine at Ohio State and received her post-graduate training in comparative pathology and laboratory animal pathology at the University of Washington in the department of Comparative Medicine. Prior to her recruitment to Ohio State, she was a comparative pathologist with the Comparative Medicine Shared Resource for 10 years at The Fred Hutchinson Cancer Research Center in Seattle, Washington. Dr. Knoblaugh shares responsibility for all projects with Dr. Krista La Perle and Dr. Kara Corps, including pre-submission consultations, macroscopic lesion interpretation, histologic tissue evaluation, clinical pathology data interpretation and final report preparation. She also meets with investigative staff to discuss findings, demonstrate pertinent lesions, recommend ancillary tests and plan subsequent studies.

Kara N. Corps, DVM, PhD, Dipl. ACVP, is a comparative pathologist with the CPMPSR and an assistant professor at The Ohio State University. Dr. Corps is a board certified veterinary pathologist with expertise in toxicologic and comparative pathology of animal models. She earned her DVM degree from Michigan State University and completed a MS in Comparative Medicine and Integrative Biology while in veterinary school. She received her post-graduate training in anatomic pathology at North Carolina State University and earned her PhD in neuroscience at the National Institutes of Health. Dr. Corps shares responsibility for all projects with Dr. Krista La Perle and Dr. Sue Knoblaugh, including pre-submission consultations, macroscopic lesion interpretation, histologic tissue evaluation, clinical pathology data interpretation and final report preparation. She also meets with investigative staff to discuss findings, demonstrate pertinent lesions, recommend ancillary tests and plan subsequent studies.

Janae’ DuLaney, BS, MLS (ASCP), is a medical laboratory technologist for the CPMPSR. She has over three years of medical laboratory experience in the blood bank and student health services laboratory at Ohio State. In addition, she has valuable experiences as a small animal veterinary technician and working with mice in an Ohio State research lab as well as at Battelle Memorial Institute. DuLaney received her BS in Biology from Eastern Michigan University and her Medical Laboratory Science degree from Ohio State. She is certified by the American Society for Clinical Pathology (ASCP).

Julie Rectenwald, AHT, MLT, is a research assistant and expert in coordinating histopathology for good laboratory practice (GLP) animal studies with over 25 years of experience in the field. Rectenwald processes samples, performs gross dissections, collects blood samples, weighs animals and tissues, identifies gross lesions and harvests and trims tissues for histology. Additionally, she takes digital gross photographs and performs radiography, offers investigators instruction on tissue collection, fixation and trimming, and assists investigators with organizing and coordinatinganimal studies. Rectenwald received Associate of Applied Sciences degrees in Animal Health Technology and Medical Laboratory Technology from Columbus Technical Institute and Columbus State Community College, respectively.

Jenny Bolon, RVT, is a veterinary technologist and virtual microscopy lab demonstrator. She performs digital slide scanning with the Leica ScanScope XT. Prior to joining the CPMPSR and the Department of Veterinary Biosciences in December 2013, Bolon supported radiographic, fluoroscopic and MRI imaging of Ohio State Veterinary Medical Center patients for more than 23 years.

David Hart, BS, HT (ASCP), manages the histology/immunohistochemistry laboratory. A histotechnologist who's certified by the American Society for Clinical Pathology (ASCP), Hart has more than 17 years of experience in all aspects of histology/immunohistochemistry and is responsible for technical and administrative oversight of the CPMPSR histology/immunohistochemistry lab. Hart received his BS in Animal Science from the Ohio State University.

Chelssie Breece, BS, HTL (ASCP), is a histotechnologist certified by the American Society for Clinical Pathology (ASCP) with more than six years of expertise in embedding, sectioning and performing routine, special histochemical and immunohistochemical stains. Breece received her BS in Forensics from the Ohio State University. She also has previous work experience in the Ohio State University Germ Free Laboratory and at the Ohio Department of Agriculture Animal Disease Diagnostic Laboratory.

Tessa VerStraete, BS, RVT, is a histotechnologist with over two years of expertise in embedding, sectioning and performing routine histochemical stains, as well as gross dissections of animal models. VerStraete received her BS in Animal Science from the Ohio State University and her AA in Veterinary Technology from Columbus State Community College.

Brenda Wilson, is a histotechnologist with 20 years of valuable experience in the medical field. She has worked with paraffin and frozen sections in both clinical and research settings, and has performed routine, special histochemical and immunohistochemical stains.

Equipment 

The Comparative Pathology and Mouse Phenotyping Shared Resource (CPMPSR) utilizes the following instruments and equipment:

Necropsy Lab (471 VMAB)

  • Euthanex SMARTBOX Unit
  • TBJ 36-84-S Down-Draft Necropsy Table (7 feet, height-adjustable) 
  • Necropsy Equipment 
  • Olympus SZ-6145TR Stereozoom Microscope with base illumination and attached SC30 digital camera 
  • Hewlett Packard Faxitron Series Cabinet X-Ray System
  • MOPEC LD500 Ventilated Tissue Storage Cabinet
  • Photographic Equipment (Nikon D90 digital SLR with 60 2.8 micro lens, photo stand, lighting) 

Clinical Pathology Lab (467 VMAB)

  • Fisher Double Door Refrigerator 
  • Thermo Forma freezer (-70° C) 
  • Beckman Allegra X-22 Refrigerated Centrifuge
  • Eppendorf Refrigerated Centrifuge 
  • Oxford Science GENESIS Hematology Analyzer
  • Alfa Wasserman Vet Axcel Chemistry Analyzer
  • Aerospray hematology slide stainer-centrifuge with Cytopro rotor 
  • Doubled-Headed Olympus BX41 Light Microscope with attached LC30 digital camera

Histology Lab (302/312 Goss)

  • Pacific Southwest Prep Station Lab Down-Draft Tissue Trimming Station (4 feet)
  • Leica HistoCore Peloris 3 – Dual-Retort Rapid Tissue Processor
  • Leica ASP300S Tissue Processor
  • Fischer Histomatic 266 MP Tissue Processor Shandon HistoCentre 2 Embedding Station
  • Tissue Tek Embedding Station
  • Sakura 4710 Embedding Station
  • 5 Leica RM2255 Automatic Microtomes
  • Leica ST5020 Multistainer
  • Leica AutoStainer XL
  • Dako Universal Training Center and Thermo Scientific 360-2D + PT module Immunohistochemistry Autostainers
  • Leica Bond RX
  • 2 Leica IPS Modular Histology Slide Printers
  • Leica CM1950 Cryostat
  • LKB Bromma 2218 Historange Microtome fitted with a tungsten carbide blade
  • LKB Bromma Ultramicrotome NOVA
  • Olympus BX-40 two-headed light microscope
  • Beecher Instruments MTA1 manual tissue microarrayer

Digital Microscopy Suite (310 Goss)

6-Headed Microscope Lab (933 BRT)

  • Six-Headed Olympus BX51 Light Microscope with attached SC30 digital camera and cellSens software linked to a 42” Panasonic plasma television

Contact Us

Comparative Pathology and Mouse Phenotyping Shared Resource Main Laboratory


Ohio State’s College of Veterinary Medicine
467/471 Veterinary Medicine Academic Building
1900 Coffey Rd.
Columbus, Ohio 43210

Phone: 614-247-8122
Email: CPMPSR@cvm.osu.edu

Availability: Monday-Friday
Hours: 8 a.m.-5 p.m.

Main Histology/Immunohistochemistry Laboratory


Ohio State’s College of Veterinary Medicine
302/312 Goss Laboratory
1925 Coffey Rd.
Columbus, Ohio 43210

Phone: 614-292-3327
Email: CPMPSR@cvm.osu.edu

Availability: Monday-Friday
Hours: 8 a.m.-5 p.m.

Digital Microscopy and Image Analysis Suite


Ohio State’s College of Veterinary Medicine
310 Goss Laboratory
1925 Coffey Rd.
Columbus, Ohio 43210

Phone: 614-247-4795
Email: CPMPSR@cvm.osu.edu

Availability: Monday-Friday
Hours: 8 a.m.-5 p.m.

Six-Headed Microscope Laboratory


933 Biomedical Research Tower
460 W. 12th Ave.
Columbus, Ohio 43210

Phone: 614-247-8122
Email: CPMPSR@cvm.osu.edu

Availability: Monthly pathologist office hours every second Tuesday of the month from 3-5 pm; microscope scheduling upon request.

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