Genetically Engineered Mouse Modeling

Director: Vincenzo Coppola, MD

Modeling human disease in mouse provides a powerful tool for elucidating mechanisms and interrogating experimental therapeutics. The Genetically Engineered Mouse Modeling Core (GEMMC) is available to investigators who work or intend to work with mouse models of human disease.

The GEMMC team has extensive experience both in generating and maintaining genetically engineered mouse lines. The team can assist in producing classical transgenic lines by pronuclear injection of DNA and targeted lines (knock-out, knock-in, conditional) by embryonic stem cell technology. The GEMMC is also able to create mutant mouse lines using the recently established CRISPR/CAS9 technology. It also offers all other ancillary services, including sperm or embryo cryopreservation, rederivation and in vitro fertilization (IVF).

The GEMMC director and staff are interested in helping investigators with minimal experience who want to start using mouse models to complement and strengthen their in vivo studies or grant proposals.


  • Director: Vincenzo Coppola, MD
  • Assistant Director: Xin-An Pu, PhD 

Vincenzo Coppola, MD, is an assistant professor in the Department of Molecular Virology, Immunology and Medical Genetics in Ohio State’s College of Medicine. He joined the Ohio State faculty in 2010 after nine years of heading the Gene Targeting Facility in the Mouse Cancer Genetics Program at the National Cancer Institute (NCI).

Dr. Coppola earned his MD at Federico II University in Naples, Italy, where he also served his medical residency. He received specialized oncology training at the University of Padua and completed a postdoctoral fellowship at the NCI.

Dr. Coppola’s personal research focuses on the role of the “adaptome” in cancer. His lab is currently studying the role of a new scaffold protein, RanBPM, which coordinates different pathways relevant to cancer.

Xin-An Pu, PhD, is an adjunct assistant professor in the Department of Neuroscience in Ohio State’s College of Medicine and a research specialist at the OSUCCC – James. She earned her PhD at the University of Missouri and completed postdoctoral training at Cornell University.  

Contact Us

Genetically Engineered Mouse Modeling
988 Biomedical Research Tower
460 W. 12th Ave.
Columbus, Ohio 43210 

Phone: 614-688-8038

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