Director: David Lucas, PhD
Senior Faculty Advisor: Clara D. Bloomfield, MD
The Leukemia Tissue Bank Shared Resource (LTBSR) helps scientists translate basic research to the clinical setting by providing central collection, processing, storage and characterization of tissue samples and derivatives (plasma, serum, DNA, RNA and protein) from patients with any hematologic malignancy enrolled on Ohio State University Comprehensive Cancer Center – James Cancer Hospital and Solove Research Institute (OSUCCC – James) protocols. These samples are available to investigators at OSU and to outside collaborators who study the cellular and molecular properties of these diseases. The ability to examine tumor cells from patients is an essential part of determining the causes of cancer and developing new and effective treatments.
A National Cancer Institute-sponsored biorepository, the LTBSR has more than 40,000 vials of cryopreserved viable cells and 13,000 vials of matched frozen plasma and/or serum samples from more than 4,000 patients.
To provide central collection and processing services and a state-of-the-art repository for samples from hematologic malignancy patients enrolled on OSUCCC – James protocols.
- LTBSR Director: David Lucas, PhD
- LTBSR Laboratory Supervisor: Donna Bucci, BS
- Clinical Research Data Manager: Minh Tran, BS
David Lucas, PhD, is a research assistant professor in Ohio State’s College of Medicine, Department of Internal Medicine, Division of Hematology, and in Ohio State’s College of Pharmacy, Division of Medicinal Chemistry and Pharmacognosy. Dr. Lucas’s research interests include pharmacology of novel anti-leukemic agents and the role of transcriptional and translational regulation in tumor cell survival and drug resistance. He joined The Ohio State University in 2000 as the director of the laboratories of Experimental Therapeutics and has been on the faculty since 2007. Dr. Lucas earned his PhD at the University of Wisconsin and completed a fellowship at the Fred Hutchinson Cancer Research Center.
Donna Bucci, BS, the LTBSR laboratory supervisor, has more than 25 years of biomedical laboratory expertise and has co-authored a number of professional publications and abstracts. She created technical manuals and managed clinical trial sites for molecular virology diagnostic assays and for a tissue-based assay for testing chemotherapeutic agent effectiveness on patient tumor samples. Bucci’s areas of expertise include cell biology and immunology with an emphasis on immunohistochemistry, microscopy and flow cytometric analysis.
Minh Tran, BS, is the clinical research data manager for the LTBSR. In addition to complex data management, she is an expert in performing all aspects of sample processing, including mononuclear cell enrichment, preparing and characterizing sample derivatives, and controlling the proper storage and distribution of specimens.
The LTBSR is a central processing and storage laboratory for several multi-site clinical trials for which the principal investigator is an OSUCCC member. These include:
OSU 16227: Targeting CD200 with Samalizumab to Enhance Outcomes in Elderly Untreated Core-Binding Factor Acute Myeloid Leukemia (A. Mims, PI).
OSU 14251: A Phase Ib/II Study of Entospletinib (GS9973) Monotherapy and in Combination with Chemotherapy in subjects with Acute Myeloid Leukemia (AML). (A. Walker, PI).
OSU 17013: A Phase II Study to Assess the Efficacy of the Treatment of IDH2 Mutant AML with Targeted IDH2 Inhibition and Subsequent Response-Driven Addition of Hypomethylating Agent Therapy. (A. Mims, PI).