Director: Mitch A. Phelps, PhD
The Pharmacoanalytic Shared Resource (PhASR) supports pre-clinical and clinical drug development at The Ohio State University by providing high quality and cost-effective bioanalytical method development, quantitative sample analysis, and pharmacokinetic/pharmacodynamic experimental design, data analysis and modeling. Expertise among the PhASR personnel includes quantitative pharmacology; bioanalytical methodology, design of pharmacokinetic/pharmacodynamic studies in animal disease models and in humans enrolled in clinical trials; data analysis and modeling of PK/PD data to inform drug development decisions. The PhASR personnel are available for consultation on clinical or pre-clinical PK/PD experimental design and analysis.
Provide the OSUCCC – James and broader research and drug development community with:
- High-quality, state-of-the-art, cost-competitive analytical expertise and instrumentation for quantitation of drugs and metabolites in biological specimens
- Pharmacokinetic data (real-time when necessary) to enable pharmacologic data to be incorporated into clinical decision-making during dose escalation and interpretation of patient response and toxicity or in pre-clinical drug development efforts
- Expertise in pharmacokinetic/pharmacodynamic study design and data interpretation during submission of clinical protocols, grant proposals, study reports and publications