Director: Michael Freitas, PhD
Senior Faculty Advisor: Vickie Wysocki, PhD
Technical Director: Liwen Zhang, PhD

The Proteomics Shared Resource (PSR) provides OSUCCC – James investigators access to advanced mass spectrometry instrumentation and analysis for protein identification, characterization and quantification. Using a variety of analytical platforms, researchers are able to discover novel differentially expressed proteins in serum, urine, BAL fluid, saliva, frozen tissues, cell culture media, formalin-fixed tissues and cell lysates via labeling or label free approaches. The PSR is part of the Campus Chemical Instrument Center managed by The Ohio State University Office of Research, with significant operational management by the OSUCCC – James. The PSR is located within OSUCCC space in the Biomedical Research Tower. The PSR is an interdisciplinary unit that provides cancer researchers with technical expertise and state-of-the-art instrumentation needed to identify proteins, protein modifications, protein interactions and protein biomarkers as well as protein quantitation studies in cancer samples.

PSR's Goals

  • Provide a high-quality, affordable service for identifying proteins, protein modifications, protein interactions and protein biomarkers as well as protein quantitation studies
  • Provide consultative services and technical assistance in experimental design and implementation in protein sample preparation, separation and purification, as well as in image analysis, mass spectrometry and data mining
  • Provide education and training for basic and clinical investigators in proteomics analysis applications and capabilities
  • Provide advanced methods of sample pre-fractionation prior to mass spectrometric analysis and protein identification
  • Provide for the analysis of complex mixtures of proteins by 1D and 2D-HPLC and tandem mass spectrometry, especially for evaluating protein and chemical biomarkers for cancer and therapeutic regimens
  • Provide native MS service on protein-protein, protein-RNA, and protein-lipid complexes.
  • Provide and improve our bioinformatics services.
  • The most recent instrument (TimsTOF Pro) added to the core provides more sensitive identification with potential Ion-Mobility separation of the samples.

Cross-Institutional Work

  • ABITEC Corp.
  • Actagro
  • Air Force Research Laboratory
  • Albemarle
  • Anatrace Products, LLC
  • Applied Biomolecular Technologies
  • Battelle Memorial Institute
  • Biosortia Pharmaceuticals
  • California State University Sacramento
  • Case Western Reserve University
  • Cincinnati Childrens Hospital
  • Colorado State University
  • Columbus Nanoworks
  • Denison University
  • Enzo Life Sciences
  • Franciscan University of Steubenville
  • FreeFlow Medical Devices LLC
  • Georgia Prevention Institute
  • Guild BioSciences
  • Kent State University
  • Kent State University at East Liverpool
  • Kenyon College, Chemistry Department
  • Lerner Research Institute
  • Medical College of Wisconsin
  • Miami University
  • Miami Valley Biotech
  • MilliporeSigma
  • Mississippi State University
  • Muskingum University; Biology Dept
  • Nationwide Childrens Hospital Research Institute
  • Northeast Ohio Medical University
  • Oakley, Inc
  • Ohio University
  • Old Dominion University
  • Otterbein University
  • Plaskolite, Inc.
  • Quanta BioDesign
  • Rensselaer Polytechnic Institue
  • Research Institute at Nationwide Childrens Hospital
  • Sevivo, LLC
  • Signature Science
  • Simple-Fill, Inc.
  • Texas Childrens Hospital
  • The Michelson Found Animals Foundation, Inc.
  • The University of Akron,
  • The University of Findlay
  • UES INC.
  • Universite de Nantes
  • University at Buffalo
  • University of Arizona
  • University of Chiciago
  • University of Cincinnati
  • University of Dayton
  • University of Louisville
  • University of New Mexico
  • University of Pittsburgh
  • University of Rhode Island
  • University of Toledo
  • US FDA, Dept of OBP/CDER
  • Vantage Specialty Chemicals
  • VCU
  • Virginia Tech
  • Wright State University
  • Wright-Patterson Air Force Base
  • Youngstown State University

Contact PSR

250 Biomedical Research Tower
460 W. 12th Ave.
Columbus, OH 43210

Phone: 614-688-0521
Fax: 614-292-5955

Availability: Monday-Friday, 7 a.m.-5 p.m.

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