Zhang XF, Lv Y, Pawlik TM
In the study by Lamarca and colleagues, the authors recommended reclassification of ICC liver metastasis into an "M1a" category.(1) The study suffered from several shortcomings. As median follow-up was extremely short(11 months), the majority of survival data did not reflect "actual" events, but rather "actuarial" data. Model discrimination should have been assessed using Harrell's c-index and area under curve(AUC) along with calibration plots to assess observed versus predicted outcomes.