Brad Blaser, MD, PHD
College of Medicine
I am interested in identifying factors in the hematopoietic niche that promote the development of myeloid neoplasia. I will use patient samples from the OSUCCC Leukemia Tissue Bank to identify candidate genes which will be screened for effects on blood stem cells in the zebrafish system using genetic gain- and loss-of-function approaches. Cell biological and molecular mechanisms will be studied down to the single cell level using time-lapse video microscopy, flow cytometry, and state-of-the-art next generation sequencing techniques. Novel therapeutic approaches will be explored via chemical screens in zebrafish embryos and preclinical studies in zebrafish and murine models of leukemia.