Darrion L Mitchell, MD, PHD
Academic Title: Assistant Professor in the College of Medicine
Research Program: Molecular Carcinogenesis and Chemoprevention
About Me
More info forI am a radiation oncologist with a special interest in improving prognostic, diagnostic and treatment responses in patients with head and neck cancer and prostate cancer. I serve as an assistant professor in the Department of Radiation Oncology at The Ohio State University and as a member of the Molecular Carcinogenesis and Chemoprevention Program at the OSUCCC – James, where my research focuses on HPV negative head and neck cancer as well as the development of new selective therapy, either natural or pharmacologically created, that will improve our standard of care and broaden our treatment of recurrent/resistance disease. In parallel, I also hope to identify molecular signatures/biomarkers that are predictive of treatment outcomes and would enable personalized health care that is effective and less toxic.
Clinical Expertise
More info for- Skin Cancers
- Skull Base Tumors
- Laryngeal Cancers
- Carcinoma, Basal Cell
- Hypopharyngeal Cancers
- Carcinoma, Merkel Cell
- Salivary Gland Cancers
- Oropharyngeal Cancers
- Mouth Cancers
- Carcinoma, Squamous Cell
Where I See Patients
More info forThe Arthur G. James Cancer Hospital and Richard J. Solove Research Institute
460 W. 10th Ave. Columbus, Ohio 43210 800-293-5066 Location InformationEducation & Training
More info forInternship - Internal Medicine
- Lutheran General Hospital
1775 Dempster St, Park Ridge, IL
Medical School
- Rosalind Franklin University of Medicine/Science
3333 Green Bay Rd, North Chicago, IL
Residency - Radiation Oncology
- University of Iowa Hospitals & Clinics
200 Hawkins Dr, Iowa City, IA
- Lutheran General Hospital
Academic Office & Contact Information
More info forAcademic Office:
460 W 10th Ave
Columbus, Ohio 43210-1240Phone:
614-685-5291Email:
Darrion.Mitchell@osumc.eduReviews
More info forPatient Satisfaction Review
The overall patient satisfaction rating is an average of all patient responses to the five questions gathered from the Outpatient Oncology survey, developed by Press Ganey Associates for use in oncology clinics across the country. On behalf of The James, Press Ganey administers the survey to patients who see our providers in an outpatient clinic office. For additional information about the patient satisfaction survey, please visit our
Patient Satisfaction Survey page The comments are submitted by patients and reflect their view and opinions. The comments are not endorsed by and do not necessarily reflect the views of The James.
Publications
More info forDecember 31, 2024Comparative analysis of the tumor microbiome, molecular profiles, and immune cell abundances by HPV status in mucosal head and neck cancers and their impact on survival.
Upadhyay R, Dhakal A, Wheeler C, Hoyd R, Jagjit Singh M, Karivedu V, Bhateja P, Bonomi M, Valentin S, Gamez ME, Konieczkowski DJ, Baliga S, Grecula JC, Blakaj DM, Gogineni E, Mitchell DL, Denko NC, Spakowicz D, Jhawar SR
Cancer Biol Ther
August 19, 2024Representation of women in clinical trials supporting FDA-approval of contemporary cancer therapies.
Kalathoor S, Ghazi S, Otieno B, Babcook MA, Chen S, Nidhi N, Bae J, Pierre-Charles J, Breathett K, Mazimba S, Johnson A, Brewer L, Mohammed S, Carter RR, Bonsu JM, Ferdousi M, Kola-Kehinde O, McLaughlin E, Brammer J, Ruz P, Khan S, Odei B, Mitchell D, Wei L, Patel P, Paskett ED, Addison D
Int J Cancer
May 1, 2024Noncanonical functions of telomerase and telomeres in viruses-associated cancer.
Rasouli S, Dakic A, Wang QE, Mitchell D, Blakaj DM, Putluri N, Li J, Liu X
J Med Virol
March 19, 2024Immunoprofiles and Oncologic Outcomes of 15 Patients with Androgen Receptor-Positive Salivary Duct Carcinoma.
Gogineni E, Sells BE, Dibs K, Jhawar SR, Haring CT, Limbach AL, Konieczkowski DJ, Ma SJ, Zhu S, Baliga S, Mitchell DL, Grecula JC, Bonomi M, Bhateja P, Old MO, Seim NB, Kang SY, Rocco JW, Chakravarti A, Blakaj DM, Gamez ME
Cancers (Basel)
March 5, 2024Palliative Quad Shot Radiation Therapy with or without Concurrent Immune Checkpoint Inhibition for Head and Neck Cancer.
Upadhyay R, Gogineni E, Tocaj G, Ma SJ, Bonomi M, Bhateja P, Konieczkowski DJ, Baliga S, Mitchell DL, Jhawar SR, Zhu S, Grecula JC, Dibs K, Gamez ME, Blakaj DM
Cancers (Basel)
March 1, 2024Surrogate endpoints in clinical trials of p16-positive squamous cell carcinoma of the oropharynx: an individual patient data meta-analysis.
Gharzai LA, Morris E, Suresh K, Nguyen-Tân PF, Rosenthal DI, Gillison ML, Harari PM, Garden AS, Koyfman S, Caudell JJ, Jones CU, Mitchell DL, Krempl G, Ridge JA, Gensheimer MF, Bonner JA, Filion E, Dunlap NE, Stokes WA, Le QT, Torres-Saavedra P, Mierzwa M, Schipper MJ
Lancet Oncol
February 6, 2024Scalp Irradiation with 3D-Milled Bolus: Initial Dosimetric and Clinical Experience.
Dibs K, Gogineni E, Jhawar SM, Baliga S, Grecula JC, Mitchell DL, Palmer J, Haglund K, Andraos TY, Zoller W, Ewing A, Bonomi M, Bhateja P, Tinoco G, Liebner D, Rocco JW, Old M, Gamez ME, Chakravarti A, Konieczkowski DJ, Blakaj DM
Cancers (Basel)
January 16, 2024Systematic Implementation of Effective Quality Assurance Processes for the Assessment of Radiation Target Volumes in Head and Neck Cancer.
Gogineni E, Schaefer D, Ewing A, Andraos T, DiCostanzo D, Weldon M, Christ D, Baliga S, Jhawar S, Mitchell D, Grecula J, Konieczkowski DJ, Palmer J, Jahraus T, Dibs K, Chakravarti A, Martin D, Gamez ME, Blakaj D
Pract Radiat Oncol
December 1, 2023Outcomes of definitive local therapy with intensity-modulated radiation therapy in elderly patients ≥70 years with HPV-associated oropharyngeal cancer.
Baliga S, Yildiz V, Barve R, Farag A, Bhateja P, Gogineni E, Mitchell D, Konieczkowski D, Grecula J, Ma SJ, Zhu S, Liu X, Bonomi M, Blakaj DM
J Med Virol
November 16, 2023Factors Associated with Total Laryngectomy Utilization in Patients with cT4a Laryngeal Cancer.
Ritter AR, Yildiz VO, Koirala N, Baliga S, Gogineni E, Konieczkowski DJ, Grecula J, Blakaj DM, Jhawar SR, VanKoevering KK, Mitchell D
Cancers (Basel)
October 1, 2023Brachial Plexus Tolerance to Standard Fractionation Re-Irradiation: The Ohio State University Experience.
Dibs K, Palmer JD, Konieczkowski DJ, Gogineni E, Mitchell DL, Raval R, Baliga S, Barve R, Elguindy AN, Jhawar SR, Gamez ME, Blakaj DM
Int J Radiat Oncol Biol Phys
October 1, 2023Comparative Analysis of Tumor Microbiome, Molecular Profile and Immune Cell Abundance by HPV Status in Head and Neck Cancers and Their Impact on Survival.
Upadhyay R, Dhakal A, Karivedu V, Wheeler C, Hoyd R, Bhateja P, Bonomi M, Valentin S, Gamez ME, Konieczkowski DJ, Baliga S, Grecula JC, Blakaj DM, Gogineni E, Mitchell DL, Denko N, Jhawar SR, Spakowicz D
Int J Radiat Oncol Biol Phys
October 1, 2023Scalp Volumetric Modulated Arc Therapy Using 3D Milled Bolus: Dosimetry, Toxicity and Outcome.
Dibs K, Konieczkowski DJ, Grecula JC, Mitchell DL, Baliga S, Gogineni E, Barve R, Jhawar SR, Zoller W, Gamez ME, Blakaj DM
Int J Radiat Oncol Biol Phys
October 1, 2023Toxicity and Outcomes of Definitive Local Therapy in Elderly Patients with HPV-Associated Oropharyngeal Cancer.
Barve R, Blakaj DM, Yildiz V, Jhawar SR, Mitchell DL, Konieczkowski DJ, Gogineni E, Bhateja P, Bonomi M, Baliga S
Int J Radiat Oncol Biol Phys
September 28, 2023Radiotherapy Plus Cisplatin With or Without Lapatinib for Non-Human Papillomavirus Head and Neck Carcinoma: A Phase 2 Randomized Clinical Trial.
Wong SJ, Torres-Saavedra PA, Saba NF, Shenouda G, Bumpous JM, Wallace RE, Chung CH, El-Naggar AK, Gwede CK, Burtness B, Tennant PA, Dunlap NE, Redman R, Stokes WA, Rudra S, Mell LK, Sacco AG, Spencer SA, Nabell L, Yao M, Cury FL, Mitchell DL, Jones CU, Firat S, Contessa JN, Galloway T, Currey A, Harris J, Curran WJ, Le QT
JAMA Oncol
July 1, 2023Combination oncolytic virus, radiation therapy, and immune checkpoint inhibitor treatment in anti-PD-1-refractory cancer.
Jhawar SR, Wang SJ, Thandoni A, Bommareddy PK, Newman JH, Marzo AL, Kuzel TM, Gupta V, Reiser J, Daniels P, Schiff D, Mitchell D, LeBoeuf NR, Simmons C, Goyal S, Lasfar A, Guevara-Patino JA, Haffty BG, Kaufman HL, Silk AW, Zloza A
J Immunother Cancer
June 17, 2023Conditional Cell Reprogramming and Air-Liquid Interface Modeling Life Cycle of Oncogenic Viruses (HPV and EBV) in Epithelial Cells and Virus-Associated Human Carcinomas.
Rani AQ, Nurmemet D, Liffick J, Khan A, Mitchell D, Li J, Zhao B, Liu X
Viruses
March 15, 2023Disparities in Survival Outcomes among Racial/Ethnic Minorities with Head and Neck Squamous Cell Cancer in the United States.
Baliga S, Yildiz VO, Bazan J, Palmer JD, Jhawar SR, Konieczkowski DJ, Grecula J, Blakaj DM, Mitchell D, Henson C, Hu K, Yamoah K, Gamez ME
Cancers (Basel)
December 30, 2022Disparities in Survival Outcomes Among Black Patients with HPV-Associated Oropharyngeal Cancer.
Baliga S, Mitchell D, Yildiz V, Gongineni E, Konieczkowski D, Grecula J, Blakaj D, Liu X, Gamez ME
J Med Virol
December 8, 2022Association between Tumor Microbiome and Hypoxia across Anatomic Subsites of Head and Neck Cancers.
Dhakal A, Upadhyay R, Wheeler C, Hoyd R, Karivedu V, Gamez ME, Valentin S, Vanputten M, Bhateja P, Bonomi M, Konieczkowski DJ, Baliga S, Mitchell DL, Grecula JC, Blakaj DM, Denko NC, Jhawar SR, Spakowicz D
Int J Mol Sci
July 14, 2022Update of a prognostic survival model in head and neck squamous cell carcinoma patients treated with immune checkpoint inhibitors using an expansion cohort.
Issa M, Klamer BG, Mladkova N, Laliotis GI, Karivedu V, Bhateja P, Byington C, Dibs K, Pan X, Chakravarti A, Grecula J, Jhawar SR, Mitchell D, Baliga S, Old M, Carrau RL, Rocco JW, Blakaj DM, Bonomi M
BMC Cancer
March 1, 2022Racial and Gender Differences in Patient Satisfaction Scores Among Oncologists.
Odei BC, Pan X, Bello-Pardo E, Mitchell D, Thomas CR, Diaz DA
Am J Clin Oncol
November 1, 2021Brachial Plexus Tolerance to High-Dose Radiation in the Re-Irradiation Setting.
Dibs K, Mladkova N, DiCostanzo DJ, Baliga S, Gamez ME, Jhawar SR, Mitchell DL, Ewing A, Issa M, Karivedu V, Palmer JD, Bhateja P, Laliottis G, Konieczkowski DJ, Grecula JC, Old M, Rocco JW, Bonomi M, Blakaj DM
Int J Radiat Oncol Biol Phys
September 1, 2021Where Are the Women in Radiation Oncology? A Cross-Sectional Multi-Specialty Comparative Analysis.
Odei B, Kahn J, Holliday EB, Diaz DA, Bello-Pardo E, Odei J, Bae J, Arnett A, Raval R, Mitchell D
Adv Radiat Oncol
August 17, 2021Treatment Outcomes of Head and Neck Cancer Patients in the Elderly Receiving Different Chemoradiation Combinations: A Single-Center Experience.
Karivedu V, Bonomi M, Issa M, Blakaj A, Klamer BG, Pan X, Old M, Bhateja P, Kang S, Seim N, Ozer E, Agrawal A, Mitchell D, Gamez ME, Grecula J, Jhawar SR, Baliga S, Carrau RL, Rocco J, Blakaj D
Oncol Res Treat
September 1, 2020Identification of Clinical and Socioeconomic Predictors of Adjuvant Therapy after Trans-Oral Robotic Surgery in Patients with Oropharyngeal Squamous Cell Carcinoma.
Baliga S, Klamer B, Jhawar S, Gamez M, Mitchell D, Blakaj A, Grecula J, Gardner U, Dibs K, Old M, Seim N, Kang S, Carrau R, Agrawal A, Karivedu V, Bhateja P, Ozer E, Rocco J, Bonomi M, Blakaj D
Cancers (Basel)
July 20, 2020A predictive survival model for patients with head and neck squamous cell carcinoma treated with immune check point inhibitors.
Bonomi M, Bhateja P, Issa M, Klamer B, Pan X, Blakaj A, Karivedu V, Mousa L, Mitchell D, Gamez M, Kang S, Siem N, Old M, Carrau R, Rocco J, Blakaj D
Oral Oncol
May 11, 2020Primary vs nodal site PET/CT response as a prognostic marker in oropharyngeal squamous cell carcinoma treated with intensity-modulated radiation therapy.
Eckstein JM, Nolan N, Healy E, Wright CL, Jain A, Barney CL, Washington I, McElroy JP, Grecula JC, Wobb JL, Mitchell DL, Miller E, Gamez M, Blakaj D, Diavolitsis V, Bhatt A
Head Neck
April 1, 2020Not So Fast: Deintensification Therapy for Locally Advanced Oral Cavity Cancer.
Mitchell DL, Clinton SK, Old MO
Int J Radiat Oncol Biol Phys
Consulting and Related Relationships
More info forAt The Ohio State University Wexner Medical Center, we support a faculty member’s research and consulting in collaboration with medical device, research and/or drug companies because a faculty member’s expertise can guide important advancements in the practice of medicine and improve patient care. In order to provide effective management of these relationships, the university requires annual disclosures from all faculty members with external interests related to their university responsibilities. As of 09/30/2024, Dr. Mitchell has reported no relationships with companies or entities.
Patient Comments
I would recommend Dr. Mitchell to everyone. He is very caring, respectful, and very informative on condition. He is definitely the best!!!!
The doctors and staff are wonderful.
Cassie and Dr. Mitchell were great! Answered out questions and we felt so cared for and comfortable during and after our visit
Dr. Mitchell and staff #1!
Dr Mitchell is outstanding Dr
I am very pleased with the care I've received from the James and Dr Mitchell, I recommend it to many people who have been diagnosed. Cassie is wonderful; returns my messages in 15 minutes!! WOW!! Even after 5pm on a Friday!!WowWowWow!!!
Care is excellent, and provider never hesitates to give the time I need to talk through concerns. If that requires that I have to wait a little extra for my appointment to begin in order for him to care the same for other patients, it is worth it.
The nurses, medical student and Dr. Mitchell were all great! Very thorough, showed compassion, friendly. Especially impressed with Dr. Mitchell. As we sat in the waiting area, my wife had noticed a Dr. Walking Patients to waiting area. It was Dr. Mitchell. I've never seen that kind of service from a Dr.
Overall great treatment
The best!!
Always good
Cancer free!!!
I was particularly impressed with Dr. Mitchell's personal interaction.