Elaine R Mardis, PhD

Elaine Mardis


College of Medicine



Academic Title


Research Program

Translational Therapeutics

I am interested in cancer genomics, both from a discovery and a translational point of view. This goes to determining common driver mutations/genes and pathways that can cause cancer to develop and progress, and can tell us the best therapeutic approaches to fight these cancers on an individual, or precision medicine focused, way. My work has spanned the past nine years, applying my genomics know-how to primary discovery (TCGA, PCGP and other large privately-funded projects), to developing tools to inform clinicians about the link between genes altered in cancer and therapeutics, to the newest application of genomics in helping to determine which mutated genes result in neoantigens that may be harnessed to help the patient fight their own cancer by using the re-stimulated immune system, either through personalized vaccines, checkpoint blockade therapies, or the combination thereof.

Education and Background


  • Doctorate, University of Oklahoma

    Norman, OK (USA)

Office Location

The Institute for Genomic Medicine

700 Children’s Drive, Columbus, OH 43205



  • Applications of Immunogenomics to Cancer.

    Liu XS, Mardis ER

    Cell 168 600-612 02/09/2017

  • An mRNA Gene Expression-Based Signature to Identify FGFR1-Amplified Estrogen Receptor-Positive Breast Tumors.

    Luo J, Liu S, Leung S, Gru AA, Tao Y, Hoog J, Ho J, Davies SR, Allred DC, Salavaggione AL, Snider J, Mardis ER, Nielsen TO, Ellis MJ

    J Mol Diagn 19 147-161 01/01/2017

  • Deregulation of DUX4 and ERG in acute lymphoblastic leukemia.

    Zhang J, McCastlain K, Yoshihara H, Xu B, Chang Y, Churchman ML, Wu G, Li Y, Wei L, Iacobucci I, Liu Y, Qu C, Wen J, Edmonson M, Payne-Turner D, Kaufmann KB, Takayanagi SI, Wienholds E, Waanders E, Ntziachristos P, Bakogianni S, Wang J, Aifantis I, Roberts KG, Ma J, Song G, Easton J, Mulder HL, Chen X, Newman S, Ma X, Rusch M, Gupta P, Boggs K, Vadodaria B, Dalton J, Liu Y, Valentine ML, Ding L, Lu C, Fulton RS, Fulton L, Tabib Y, Ochoa K, Devidas M, Pei D, Cheng C, Yang J, Evans WE, Relling MV, Pui CH, Jeha S, Harvey RC, Chen IL, Willman CL, Marcucci G, Bloomfield CD, Kohlschmidt J, Mrózek K, Paietta E, Tallman MS, Stock W, Foster MC, Racevskis J, Rowe JM, Luger S, Kornblau SM, Shurtleff SA, Raimondi SC, Mardis ER, Wilson RK, Dick JE, Hunger SP, Loh ML, Downing JR, Mullighan CG, St. Jude Children's Research Hospital–Washington University Pediatric Cancer Genome Project

    Nat Genet 48 1481-1489 12/01/2016

  • Cancer Genomics: Large-Scale Projects Translate into Therapeutic Advances.

    Mardis ER, Ladanyi M

    PLoS Med 13 e1002209 12/01/2016

  • See Full List
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