About Me
More info forAs a member of the Cancer Biology Program at the OSUCCC – James, I focus my research on basic and translational research projects that aim to understand the molecular mechanisms of colorectal cancer metastasis, recurrence, tumor dormancy and drug resistance. I am also interested in identifying and validating therapeutic targets using cell culture, organoids, mouse models and patient-derived xenografts (PDXs), as well developing small-molecule inhibitors and testing their efficacy in vitro and in vivo.
My lab’s main goal is to develop effective therapies that can be tested in clinical trials. Recently, checkpoint blockade immunotherapy has shown promising results in a variety of cancers, including colorectal cancer. As existing immune checkpoint therapies are not universally effective and may be limited by toxicities, discovery of other immunotherapeutic targets and combination strategies is a priority.
My laboratory has developed several projects aiming to identify new therapeutic avenues and facilitate development of strategies to prevent cancer immune evasion and to increase therapeutic efficacy of immunotherapy.
Education & Training
More info forPost-doctoral - PhD
- Cold Spring Harbor Laboratory
Long Island, NY
USA
- Cold Spring Harbor Laboratory
Academic Office & Contact Information
More info forAcademic Office:
460 W 12th Ave
Columbus, Ohio 43210-2210Email:
wang.12230@osu.eduPublications
More info forOctober 9, 2024Riluzole Enhancing anti-PD-1 Efficacy by Activating cGAS/STING Signaling in Colorectal Cancer.
Liang B, Khan M, Storts H, Zhang EH, Zheng X, Xing X, Claybon H, Wilson J, Li C, Jin N, Fishel R, Miles WO, Wang JJ
Molecular Cancer Therapeutics
October 4, 2024Inhibition of O-GlcNAc transferase activates type I interferon-dependent antitumor immunity by bridging cGAS-STING pathway.
Chen J, Zhao B, Dong H, Li T, Cheng X, Gong W, Wang J, Zhang J, Xin G, Yu Y, Lei YL, Black JD, Li Z, Wen H
Elife
October 1, 2024Reduced Childhood Ambient Fine Particulate Matter Exposure and Subsequent Asthma Incidence: How Low Is Low Enough?
Wang JG, Bose S, Viegi G
Ann Am Thorac Soc
August 24, 2024Feasibility of Remote Spirometry Monitoring of Asthma in Pregnancy.
Wharton R, Mathis N, Wang JG, Meislin R, Liu B, Abdurrahman N, Le V, Rurak K, Hanson C, Que LG, Shaz D, Bose S
Respir Med
July 8, 2024PP2A B55α Inhibits Epithelial-Mesenchymal Transition Via Regulation of Slug Expression in Non-Small Cell Lung Cancer.
Singh D, Qiu Z, Jonathan SM, Fa P, Thomas H, Chandra BP, Cai S, Wang JJ, Yan C, Zhang X, Venere M, Li Z, Sizemore ST, Wang QE, Zhang J
Cancer Lett
June 7, 2024Bioorthogonal Labeling and Enrichment of Histone Monoaminylation Reveal Its Accumulation and Regulatory Function in Cancer Cell Chromatin.
Zhang N, Wu J, Hossain F, Peng H, Li H, Gibson C, Chen M, Zhang H, Gao S, Zheng X, Wang Y, Zhu J, Wang JJ, Maze I, Zheng Q
J Am Chem Soc
January 1, 2024Antagonistic roles of cGAS/STING signaling in colorectal cancer chemotherapy.
Front Oncol
December 18, 2023The Enrichment of miRNA-Targeted mRNAs in Translationally Less Active over More Active Polysomes.
Wang T, Tian S, Tikhonova EB, Karamyshev AL, Wang JJ, Zhang F, Wang D
Biology (Basel)
October 27, 2023SIX4 Controls anti-PD-1 Efficacy by Regulating STING Expression.
Liang B, Zhang EH, Ye Z, Storts H, Jin W, Zheng X, Hylton H, Zaleski O, Xing X, Miles W, Wang JJ
Cancer Res Commun
March 12, 2022Polymerase Epsilon-Associated Ultramutagenesis in Cancer.
Xing X, Jin N, Wang J
Cancers (Basel)
March 9, 2022Comparative Analysis of microRNA Binding Site Distribution and microRNA-Mediated Gene Expression Repression of Oncogenes and Tumor Suppressor Genes.
Tian S, Wang J, Zhang F, Wang D
Genes (Basel)
April 19, 2021The bifurcated role of adiponectin in colorectal cancer.
Chakraborty D, Jin W, Wang J
Life Sci
December 20, 2020Mechanisms of Immunosuppression in Colorectal Cancer.
Zhang Y, Rajput A, Jin N, Wang J
Cancers (Basel)
November 12, 2020The role and therapeutic implications of PI3K signaling pathway in cancer.
Leiphrakpam PD, Chowdhury S, Wang J, Black JD, Are C
J Surg Oncol
November 12, 2020Correlation of PRL3 expression with colorectal cancer progression.
Leiphrakpam PD, Lazenby AJ, Smith LM, Brattain MG, Black JD, Wang J, Are C
J Surg Oncol
October 2, 2020Nonalcoholic fatty liver disease and colorectal cancer: Correlation and missing links.
Chakraborty D, Wang J
Life Sci
June 2, 2020Neuronal uptake transporters contribute to oxaliplatin neurotoxicity in mice.
Huang KM, Leblanc AF, Uddin ME, Kim JY, Chen M, Eisenmann ED, Gibson A, Li Y, Hong KW, DiGiacomo D, Xia SH, Alberti P, Chiorazzi A, Housley SN, Cope TC, Sprowl JA, Wang J, Loprinzi CL, Noonan A, Lustberg M, Cavaletti G, Pabla N, Hu S, Sparreboom A
J Clin Invest