John L Hays, MD, PhD

John Hays

College

College of Medicine

Department/Division

Internal Medicine

Academic Title

Asst Professor

Research Program

Translational Therapeutics

Research Interest

Cancer, Ovarian Cancer, Breast Cancer, Hypersensitivity

Dr. Hays' research focuses on using proteomics based approaches to determine functionally significant signaling nodes within the tumor and the tumor microenvironment using in vitro based cell culture and co-culture systems. Dr. Hays has identified a number of phosophorylated signaling proteins that are important across multiple ovarian cancer cell lines.


Education and Background

Education

  • MD, University of Texas Medical Branch

    Galveston, TX (USA)

Residencies

  • Internal Medicine Internship

    Wake Forest University

    Winston-Salem, NC (USA)

  • Residency Internal Medicine

    Wake Forest University

    Winston-Salem, NC (USA)

Fellowship

  • Fellowship Medical Oncology Branch

    National Cancer Institute, National Institutes of Health

Office Location

Starling Loving Hall

320 W 10th Avenue, Columbus, Ohio 43210


614-292-6356



Publications


  • Akt Activation Mediates Acquired Resistance to Fibroblast Growth Factor Receptor Inhibitor BGJ398.

    Datta J, Damodaran S, Parks H, Ocrainiciuc C, Miya J, Yu L, Gardner EP, Samorodnitsky E, Wing MR, Bhatt D, Hays J, Reeser JW, Roychowdhury S

    Mol Cancer Ther 16 614-624 04/01/2017


  • Phase I/Ib study of olaparib and carboplatin in women with triple negative breast cancer.

    Lee JM, Hays JL, Chiou VL, Annunziata CM, Swisher EM, Harrell MI, Yu M, Gordon N, Sissung TM, Ji J, Figg WD, Minasian L, Lipkowitz S, Wood BJ, Doroshow J, Kohn EC

    Oncotarget in press 03/25/2017


  • Elevated STAT3 expression in ovarian cancer ascites promotes invasion and metastasis: a potential therapeutic target.

    Saini U, Naidu S, ElNaggar AC, Bid HK, Wallbillich JJ, Bixel K, Bolyard C, Suarez AA, Kaur B, Kuppusamy P, Hays J, Goodfellow PJ, Cohn DE, Selvendiran K, Saini U, Naidu S, ElNaggar AC, Bid HK, Wallbillich JJ, Bixel K, Bolyard C, Suarez AA, Kaur B, Kuppusamy P, Hays J, Goodfellow PJ, Cohn DE, Selvendiran K

    Oncogene 36 168-181 01/12/2017


  • Elevated STAT3 expression in ovarian cancer ascites promotes invasion and metastasis: a potential therapeutic target.

    Saini U, Naidu S, ElNaggar AC, Bid HK, Wallbillich JJ, Bixel K, Bolyard C, Suarez AA, Kaur B, Kuppusamy P, Hays J, Goodfellow PJ, Cohn DE, Selvendiran K, Saini U, Naidu S, ElNaggar AC, Bid HK, Wallbillich JJ, Bixel K, Bolyard C, Suarez AA, Kaur B, Kuppusamy P, Hays J, Goodfellow PJ, Cohn DE, Selvendiran K

    Oncogene 36 168-181 01/12/2017


  • Autophagy Induction Results in Enhanced Anoikis Resistance in Models of Peritoneal Disease.

    Chen JL, David J, Cook-Spaeth D, Casey S, Cohen D, Selvendiran K, Bekaii-Saab T, Hays J, Chen JL, David J, Cook-Spaeth D, Casey S, Cohen D, Selvendiran K, Bekaii-Saab T, Hays JL

    Mol Cancer Res 15 26-34 01/01/2017


  • Autophagy Induction Results in Enhanced Anoikis Resistance in Models of Peritoneal Disease.

    Chen JL, David J, Cook-Spaeth D, Casey S, Cohen D, Selvendiran K, Bekaii-Saab T, Hays J, Chen JL, David J, Cook-Spaeth D, Casey S, Cohen D, Selvendiran K, Bekaii-Saab T, Hays JL

    Mol Cancer Res 15 26-34 01/01/2017


  • Association of breast cancer risk in BRCA1 and BRCA2 mutation carriers with genetic variants showing differential allelic expression: identification of a modifier of breast cancer risk at locus 11q22.3.

    Hamdi Y, Soucy P, Kuchenbaeker KB, Pastinen T, Droit A, Lemaçon A, Adlard J, Aittomäki K, Andrulis IL, Arason A, Arnold N, Arun BK, Azzollini J, Bane A, Barjhoux L, Barrowdale D, Benitez J, Berthet P, Blok MJ, Bobolis K, Bonadona V, Bonanni B, Bradbury AR, Brewer C, Buecher B, Buys SS, Caligo MA, Chiquette J, Chung WK, Claes KB, Daly MB, Damiola F, Davidson R, De la Hoya M, De Leeneer K, Diez O, Ding YC, Dolcetti R, Domchek SM, Dorfling CM, Eccles D, Eeles R, Einbeigi Z, Ejlertsen B, EMBRACE, Engel C, Gareth Evans D, Feliubadalo L, Foretova L, Fostira F, Foulkes WD, Fountzilas G, Friedman E, Frost D, Ganschow P, Ganz PA, Garber J, Gayther SA, GEMO Study Collaborators, Gerdes AM, Glendon G, Godwin AK, Goldgar DE, Greene MH, Gronwald J, Hahnen E, Hamann U, Hansen TV, Hart S, Hays JL, HEBON, Hogervorst FB, Hulick PJ, Imyanitov EN, Isaacs C, Izatt L, Jakubowska A, James P, Janavicius R, Jensen UB, John EM, Joseph V, Just W, Kaczmarek K, Karlan BY, KConFab Investigators, Kets CM, Kirk J, Kriege M, Laitman Y, Laurent M, Lazaro C, Leslie G, Lester J, Lesueur F, Liljegren A, Loman N, Loud JT, Manoukian S, Mariani M, Mazoyer S, McGuffog L, Meijers-Heijboer HE, Meindl A, Miller A, Montagna M, Mulligan AM, Nathanson KL, Neuhausen SL, Nevanlinna H, Nussbaum RL, Olah E, Olopade OI, Ong KR, Oosterwijk JC, Osorio A, Papi L, Park SK, Pedersen IS, Peissel B, Segura PP, Peterlongo P, Phelan CM, Radice P, Rantala J, Rappaport-Fuerhauser C, Rennert G, Richardson A, Robson M, Rodriguez GC, Rookus MA, Schmutzler RK, Sevenet N, Shah PD, Singer CF, Slavin TP, Snape K, Sokolowska J, Sønderstrup IM, Southey M, Spurdle AB, Stadler Z, Stoppa-Lyonnet D, Sukiennicki G, Sutter C, Tan Y, Tea MK, Teixeira MR, Teulé A, Teo SH, Terry MB, Thomassen M, Tihomirova L, Tischkowitz M, Tognazzo S, Toland AE, Tung N, van den Ouweland AM, van der Luijt RB, van Engelen K, van Rensburg EJ, Varon-Mateeva R, Wappenschmidt B, Wijnen JT, Rebbeck T, Chenevix-Trench G, Offit K, Couch FJ, Nord S, Easton DF, Antoniou AC, Simard J

    Breast Cancer Res Treat 161 117-134 01/01/2017


  • Evaluation of Polygenic Risk Scores for Breast and Ovarian Cancer Risk Prediction in BRCA1 and BRCA2 Mutation Carriers.

    Kuchenbaecker KB, McGuffog L, Barrowdale D, Lee A, Soucy P, Dennis J, Domchek SM, Robson M, Spurdle AB, Ramus SJ, Mavaddat N, Terry MB, Neuhausen SL, Schmutzler RK, Simard J, Pharoah PD, Offit K, Couch FJ, Chenevix-Trench G, Easton DF, Antoniou AC, Hays L, Kuchenbaecker KB, McGuffog L, Barrowdale D, Lee A, Soucy P, Dennis J, Domchek SM, Robson M, Spurdle AB, Ramus SJ, Mavaddat N, Terry MB, Neuhausen SL, Schmutzler RK, Simard J, Pharoah PD, Offit K, Couch FJ, Chenevix-Trench G, Easton DF, Antoniou AC, Kuchenbaecker KB, McGuffog L, Barrowdale D, Lee A, Soucy P, Dennis J, Domchek SM, Robson M, Spurdle AB, Ramus SJ, Mavaddat N, Terry MB, Neuhausen SL, Schmutzler RK, Simard J, Pharoah PDP, Offit K, Couch FJ, Chenevix-Trench G, Easton DF, Antoniou AC, Lush M, Hamann U, Southey M, John EM, Chung WK, Daly MB, Buys SS, Goldgar DE, Dorfling CM, van Rensburg EJ, Chun Ding Y, Ejlertsen B, Gerdes AM, Hansen TV, Slager S, Hallberg E, Benitez J, Osorio A, Cohen N, Lawler W, Weitzel JN, Peterlongo P, Pensotti V, Dolcetti R, Barile M, Bonanni B, Azzollini J, Manoukian S, Peissel B, Radice P, Savarese A, Papi L, Giannini G, Fostira F, Konstantopoulou I, Adlard J, Brewer C, Cook J, Davidson R, Eccles D, Eeles R, Ellis S, Frost D, Hodgson S, Izatt L, Lalloo F, Ong KR, Godwin AK, Arnold N, Dworniczak B, Engel C, Gehrig A, Hahnen E, Hauke J, Kast K, Meindl A, Niederacher D, Schmutzler RK, Varon-Mateeva R, Wang-Gohrke S, Wappenschmidt B, Barjhoux L, Collonge-Rame MA, Elan C, Golmard L, GEMO Study Collaborators, EMBRACE, Barouk-Simonet E, Lesueur F, Mazoyer S, Sokolowska J, Stoppa-Lyonnet D, Isaacs C, Claes KBM, Poppe B, de la Hoya M, Garcia-Barberan V, Aittomaki K, Nevanlinna H, Ausems MGEM, de Lange JL, Gomez Garcia EB, Hogervorst FB, HEBON, Kets CM, Meijers-Heijboer HE, Oosterwijk JC, Rookus MA, van Asperen CJ, van den Ouweland AMW, van Doorn HC, van Os TAM, Kwong A, Olah E, Diez O, Brunet J, Lazaro C, Teule A, Gronwald J, Jakubowska A, Kaczmarek K, Lubinski J, Sukiennicki G, Barkardottir RB, Chiquette J, Agata S, Montagna M, Teixeira MR, Kyung Park S, KConFab Investigators, Olswold C, Tischkowitz M, Foretova L, Gaddam P, Vijai J, Pfeiler G, Rappaport-Fuerhauser C, Singer CF, Tea MKM, Greene MH, Loud JT, Rennert G, Imyanitov EN, Hulick PJ, Hays JL, Piedmonte M, Rodriguez GC, Martyn J, Glendon G, Mulligan AM, Andrulis IL, Toland AE, Jenson UB, Kruse TA, Sokilde Pedersen I, Thomassen M, Caligo MA, Teo SH, Berger R, Friedman E, Laitman Y, Arver B, Borg A, Ehrancrona H, Rantala J, Olopade OI, Ganz PA, Nussbaum RL, Bradbury AR, Domchek SM, Nathanson KL, Arun BK, James P, Karlan BY, Lester J, Simard J, Pharoah PDP, Offit K, Couch FJ, Chenevix-Trench G, Easton DF, Antoniou AC, Kuchenbaecker KB, McGuffog L, Barrowdale D, Lee A, Soucy P, Dennis J, Domchek SM, Robson M, Spurdle AB, Ramus SJ, Mavaddat N, Terry MB, Neuhausen SL, Schmutzler RK, Simard J, Pharoah PDP, Offit K, Couch FJ, Chenevix-Trench G, Easton DF, Antoniou AC

    J Natl Cancer Inst 109 01/01/2017


  • Mixed Adeno-neuroendocrine Carcinoma: An Aggressive Clinical Entity.

    Brathwaite S, Rock J, Yearsley MM, Bekaii-Saab T, Wei L, Frankel WL, Hays J, Wu C, Abdel-Misih S

    Ann Surg Oncol 23 2281-6 07/01/2016


  • Addition of Everolimus Post VEGFR Inhibition Treatment Failure in Advanced Sarcoma Patients Who Previously Benefited from VEGFR Inhibition: A Case Series.

    ElNaggar AC, Hays JL, Chen JL

    PLoS One 11 e0156985 01/01/2016


  • Appendiceal Mixed Adeno-Neuroendocrine Carcinoma: A Population-Based Study of the Surveillance, Epidemiology, and End Results Registry.

    Brathwaite S, Yearsley MM, Bekaii-Saab T, Wei L, Schmidt CR, Dillhoff ME, Frankel WL, Hays JL, Wu C, Abdel-Misih S

    Front Oncol 6 148 01/01/2016


  • Olaparib in the management of ovarian cancer.

    Bixel K, Hays JL

    Pharmgenomics Pers Med 8 127-35 01/01/2015

  • See Full List
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