Jonathan W Song, PhD
Academic Title: Associate Professor in the College of Engineering
Research Program: Cancer Biology
About Me
More info forI am a member of the Cancer Biology Program at the OSUCCC – James, where I bring an engineering perspective to my research.
In particular, I use microscale engineering technology to reconstitute the microarchitecture of living tissue in vitro to investigate how tumor microenvironment components regulate angiogenesis and metastasis.
I also seek to deploy engineered microsystems for large scale, high-throughput platforms for pre-clinical screening of multi-target anti-angiogenesis therapy.
I have authored or co-authored publications in several scientific journals, including The FASEB Journal, Proceedings of the National Academy of Sciences, Advanced Materials, Oncotarget, Angiogenesis, Neoplasia and Journal of the National Cancer Institute.
Academic Office & Contact Information
More info forAcademic Office:
201 W 19th Ave
Columbus, Ohio 43210-1142Phone:
614-292-8519Email:
song.1069@osu.eduPublications
More info forOctober 14, 2024Rapid low-cost assembly of modular microvessel-on-a-chip with benchtop xurography.
Agarwal SS, Cortes-Medina M, Holter JC, Avendano A, Tinapple JW, Barlage JM, Menyhert MM, Onua LM, Song JW
Lab Chip
December 13, 2023Chondroitin sulfate, dermatan sulfate, and hyaluronic acid differentially modify the biophysical properties of collagen-based hydrogels.
Cortes-Medina M, Bushman AR, Beshay PE, Adorno JJ, Menyhert MM, Hildebrand RM, Agarwal SS, Avendano A, Friedman AK, Song JW
Acta Biomater
March 14, 2023Extracellular Matrix-Derived Biophysical Cues Mediate Interstitial Flow-Induced Sprouting Angiogenesis.
Chang CW, Shih HC, Cortes-Medina MG, Beshay PE, Avendano A, Seibel AJ, Liao WH, Tung YC, Song JW
ACS Appl Mater Interfaces
December 12, 2022Multiplexed Detection of Molecular Interactions with DNA Origami Engineered Cells in 3D Collagen Matrices.
Shahhosseini M, Beshay PE, Akbari E, Roki N, Lucas CR, Avendano A, Song JW, Castro CE
ACS Appl Mater Interfaces
November 10, 2022Low cost and massively parallel force spectroscopy with fluid loading on a chip.
Akbari E, Shahhosseini M, Robbins A, Poirier MG, Song JW, Castro CE
Nat Commun
May 1, 2022Evaluating the Effects of Chondroitin Sulfate and Hyaluronic Acid in Modifying the Properties of Collagen-Based Matrices.
Cortes-Medina MG, Bushman A, Beshay P, Adorno JJ, Menyhert MM, Hildebrand R, Avendano A, Song JW
FASEB J
February 8, 2022cPLA2 blockade attenuates S100A7-mediated breast tumorigenicity by inhibiting the immunosuppressive tumor microenvironment.
Mishra S, Charan M, Shukla RK, Agarwal P, Misri S, Verma AK, Ahirwar DK, Siddiqui J, Kaul K, Sahu N, Vyas K, Garg AA, Khan A, Miles WO, Song JW, Bhutani N, Ganju RK
J Exp Clin Cancer Res
January 1, 2022The biophysics of cancer: emerging insights from micro- and nanoscale tools.
Beshay PE, Cortes-Medina MG, Menyhert MM, Song JW
Adv Nanobiomed Res
January 1, 2022Molecular sensors for detection of tumor-stroma crosstalk.
Fuller BT, Buczynksi EM, Beshay PE, Song JW
Adv Cancer Res
January 1, 2022Fibroblast-derived CXCL12 increases vascular permeability in a 3-D microfluidic model independent of extracellular matrix contractility.
Holter JC, Chang CW, Avendano A, Garg AA, Verma AK, Charan M, Ahirwar DK, Ganju RK, Song JW
Front Bioeng Biotechnol
November 26, 2021Tumor treating fields: An emerging treatment modality for thoracic and abdominal cavity cancers.
Jones TH, Song JW, Abushahin L
Transl Oncol
September 1, 2021Endothelial barrier function is co-regulated at vessel bifurcations by fluid forces and sphingosine-1-phosphate.
Akbari E, Spychalski GB, Menyhert MM, Rangharajan KK, Tinapple JW, Prakash S, Song JW
Biomater Biosyst
March 1, 2021Directional Migration of Breast Cancer Cells Hindered by Induced Electric Fields May Be Due to Accompanying Alteration of Metabolic Activity.
Jones TH, Kaul K, Garg AA, Song JW, Ganju RK, Subramaniam VV
Bioelectricity
December 15, 2020Direct current electric field regulates endothelial permeability under physiologically relevant fluid forces in a microfluidic vessel bifurcation model.
Mohana Sundaram P, Rangharajan KK, Akbari E, Hadick TJ, Song JW, Prakash S
Lab Chip
November 11, 2020Vessel-on-a-chip models for studying microvascular physiology, transport, and function in vitro.
Moses SR, Adorno JJ, Palmer AF, Song JW
Am J Physiol Cell Physiol
May 5, 2020In utero estrogenic endocrine disruption alters the stroma to increase extracellular matrix density and mammary gland stiffness.
Wormsbaecher C, Hindman AR, Avendano A, Cortes-Medina M, Jones CE, Bushman A, Onua L, Kovalchin CE, Murphy AR, Helber HL, Shapiro A, Voytovitch K, Kuang X, Aguilar-Valenzuela R, Leight JL, Song JW, Burd CJ
Breast Cancer Res