Kamalakannan Palanichamy, PhD
College of Medicine
Asst Professor - Clinical
Glioblastoma, Cancer, Glioma, Brain Cancer, Endoplasmic Reticulum Stress, Tumor Escape, Diabetes Mellitus, Neurodegenerative diseases
Through his research as a member of the OSUCCC – James Translational Therapeutics Program, Kamalakannan Palanichamy, PhD, seeks to explore transcriptomic, epigenetic, metabolomics, proteomic and genomic profiles of patient biopsies in order to identify the mechanisms of chemo and radiation resistance in treatment refractory tumors.Dr. Palanichamy has identified predictive and prognostic markers, elucidated the underlying mechanisms and validated them using clinically relevant models. His group is also working to identify and eradicate cancer stem cells within the bulk of tumors using pre-clinical models and patient-derived cancer stem cells. His recent work identified antigens encoding this sub-population of cells expressing iPSC genes with differentiation plasticity. He showed that the treatment-resistant tumor initiating cells can be inhibited by using growth factors. Dr. Palanichamy has utilized tools from each aspect of his unique background in biology, biochemistry, bioinformatics, crystallography, drug design and oncology for more than a decade and has co-authored more than 40 articles appearing in such respected journals as Cancer Research, Clinical Cancer Research, Neuro-Oncology, Journal of Neuro-Oncology, FEBS and Journal of Inorganic Biochemistry, among others.
385E Wiseman Hall
400 W 12th Ave, Columbus, OH 43210