Mohamed H Abdel-Rahman, MD, PhD
College of Medicine
Molecular Biology and Cancer Genetics
Melanoma, Cancer, Neoplasm Metastasis, Retinal Detachment, Choroidal Neovascularization, Liver Diseases, Monosomy, Neoplastic Syndromes, Hereditary, Loss of Heterozygosity, Mesothelioma
Mohamed Abdel-Rahman, MD, PhD, is a member of the Molecular Biology and Cancer Genetics Program at the OSUCCC – James, where he focuses his research on molecular diagnosis of ocular melanoma, identification of novel targets for ocular melanoma therapy and hereditary predisposition to ocular melanoma.
His work includes developing a clinical trial for managing uveal melanoma patients with a high risk for systemic metastasis. His research has identified a novel hereditary cancer predisposition syndrome caused by germline mutation in the BAP1 gene that increases the risk for several cancers including ocular melanoma, skin melanoma, kidney cancer and mesothelioma. It also produced data that highlights the importance of pigmentary genes in the development of ocular melanoma.
Dr. Abdel-Rahman has co-authored numerous articles appearing in well-known publications, including Journal Medical Genetics, Scientific Reports, Familial Cancer, Clinical Genetics, Ophthalmic Genetics, and Genes, Chromosomes and Cancer. He also co-authored the NCBI genereview clinical guideline for diagnosis and management of the BAP1-tumor predisposition syndrome.