Patrick L Green, PhD
College of Veterinary Medicine
Leukemia-Lymphoma, Adult T-Cell, Human T-Lymphotropic Virus 1
Patrick Green, PhD, is a professor and associate dean for research and graduate studies in the College of Veterinary Medicine at Ohio State, where he also directs the Center for Retrovirus Research. He is the associate director for basic sciences at the OSUCCC – James and a member of the Leukemia Research Program.
Dr. Green’s research focuses on understanding the molecular basis of T-lymphocyte transformation, as well as the induction of leukemia/lymphoma and neurological diseases by the human T-cell leukemia viruses (HTLVs). He investigates viral and cellular regulators of HTLV gene expression/replication, cellular transformation and virus survival or persistence in infected hosts.
Recent work has revealed the importance of a viral gene, termed Hbz, in the maintenance and proliferation of HTLV-1 infected cells. In fact, Hbz is the only viral gene consistently expressed in HTLV-1 associated adult T cell leukemia/lymphoma. Hbz and the cellular pathways it impacts will be important targets for treatment and prevention of HTLV-1-associated diseases.
Dr. Green has authored or co-authored many articles in well-regarded journals, including Viruses, Journal of Virology, Journal of Biological Chemistry and Cancer Cell.