Peixuan Guo, PhD
Academic Title: Professor & Sylvan G. Frank Endowed Chair
Research Program: Translational Therapeutics
Columbus, Ohio 43210-2210
About Me
More info forAs a member of the Translational Therapeutics Program at the OSUCCC – James, I conduct research focusing on the application of RNA nanotechnology for cancer therapy. My lab has developed multifunctional RNA nanoparticles harboring RNA aptamer, siRNA, miRNA, anti-miRNA, ribozymes and chemical drugs.
As early as 1976, I reported that cells have many small RNA molecules with novel yet undiscovered functions and named them “sRNA,” and in 1998, my lab proved the concept of RNA nanotechnology. Six years later, I predicted that RNA would be the third milestone in drug development, and the recent approval of three RNA-based drugs by the FDA demonstrates that this third milestone is coming.
Our RNA nanoparticles are homogeneous in size and structure, thermodynamically and chemically stable, non-toxic, non-immunogenic and display favorable pharmacological profiles without side effects. After systemic injection, the RNA nanoparticles target tumors with little or no accumulation in healthy organs.
In addition to this research, my lab is interested in exploring image-guided drug delivery and cancer immunotherapy, as well as the use of a viral motor channel for single-pore sensing of DNA, RNA and protein, and the diagnosis of diseases.
I have published many articles in well-respected journals, including Nanomedicine, Nature Nanotechnology, Oncotarget, Methods in Molecular Biology and Journal of Virology.
Academic Office & Contact Information
More info forAcademic Office:
Biomedical Research Tower 0406
460 W 12th Ave
Columbus, Ohio 43210-2210Phone:
614-293-2114Email:
guo.1091@osu.eduPublications
More info forOctober 4, 2024Engineered Extracellular Vesicles for Combinatorial TNBC Therapy: SR-SIM-Guided Design Achieves Substantial Drug Dosage Reduction.
Bhullar AS, Jin K, Shi H, Jones A, Hironaka D, Xiong G, Xu R, Guo P, Binzel DW, Shu D
Mol Ther
June 4, 2024Cracking the Code: Enhancing Molecular Tools for Progress in Nanobiotechnology.
Avila YI, Rebolledo LP, Skelly E, de Freitas Saito R, Wei H, Lilley D, Stanley RE, Hou YM, Yang H, Sztuba-Solinska J, Chen SJ, Dokholyan NV, Tan C, Li SK, He X, Zhang X, Miles W, Franco E, Binzel DW, Guo P, Afonin KA
ACS Appl Bio Mater
April 22, 2024Posterior eye delivery of angiogenesis-inhibiting RNA nanoparticles via subconjunctival injection.
Zhong C, Shi Z, Binzel DW, Jin K, Li X, Guo P, Kevin Li S
Int J Pharm
January 12, 2024In Vitro and In Vivo Evaluation of the Pathology and Safety Aspects of Three- and Four-Way Junction RNA Nanoparticles.
Jin K, Liao YC, Cheng TC, Li X, Lee WJ, Pi F, Jasinski D, Chen LC, Phelps MA, Ho YS, Guo P
Mol Pharm
December 21, 2023RNA four-way junction (4WJ) for spontaneous cancer-targeting, effective tumor-regression, metastasis suppression, fast renal excretion and undetectable toxicity.
Li X, Jin K, Cheng TC, Liao YC, Lee WJ, Bhullar AS, Chen LC, Rychahou P, Phelps MA, Ho YS, Guo P
Biomaterials
September 12, 2023Tumor targeting and therapeutic assessments of RNA nanoparticles carrying α9-nAChR aptamer and anti-miR-21 in triple-negative breast cancers.
Liao YC, Cheng TC, Tu SH, Chang J, Guo P, Chen LC, Ho YS
Mol Ther Nucleic Acids
September 12, 2023Targeting oncogenic KRAS in non-small cell lung cancer with EGFR aptamer-conjugated multifunctional RNA nanoparticles.
Yang L, Li Z, Binzel DW, Guo P, Williams TM
Mol Ther Nucleic Acids
April 1, 2023Targeted delivery of RNAi to cancer cells using RNA-ligand displaying exosome.
Uddin N, Binzel DW, Shu D, Fu TM, Guo P
Acta Pharm Sin B
March 20, 2023Ligand-displaying-exosomes using RNA nanotechnology for targeted delivery of multi-specific drugs for liver cancer regression.
Ellipilli S, Wang H, Binzel DW, Shu D, Guo P
Nanomedicine
December 26, 2022Nipple fluid for breast cancer diagnosis using the nanopore of Phi29 DNA-packaging motor.
Zhang L, Burns N, Ji Z, Sun S, Deutscher SL, Carson WE, Guo P
Nanomedicine
May 5, 2022The dynamic, motile and deformative properties of RNA nanoparticles facilitate the third milestone of drug development.
Li X, Bhullar AS, Binzel DW, Guo P
Adv Drug Deliv Rev
January 19, 2022Targeting squalene epoxidase interrupts homologous recombination via the ER stress response and promotes radiotherapy efficacy.
Hong Z, Liu T, Wan L, Fa P, Kumar P, Cao Y, Prasad CB, Qiu Z, Liu J, Wang H, Li Z, Wang QE, Guo P, Guo D, Yilmaz AS, Lu L, Papandreou I, Jacob NK, Yan C, Zhang X, She QB, Ma Z, Zhang J
Cancer Res
January 1, 2022Biomotors, viral assembly, and RNA nanobiotechnology: Current achievements and future directions.
Rolband L, Beasock D, Wang Y, Shu YG, Dinman JD, Schlick T, Zhou Y, Kieft JS, Chen SJ, Bussi G, Oukhaled A, Gao X, Šulc P, Binzel D, Bhullar AS, Liang C, Guo P, Afonin KA
Comput Struct Biotechnol J
October 22, 2021The International Society of RNA Nanotechnology and Nanomedicine (ISRNN): The Present and Future of the Burgeoning Field.
Chandler M, Johnson B, Khisamutdinov E, Dobrovolskaia MA, Sztuba-Solinska J, Salem AK, Breyne K, Chammas R, Walter NG, Contreras LM, Guo P, Afonin KA
ACS Nano
September 3, 2021Rational design for controlled release of Dicer-substrate siRNA harbored in phi29 pRNA-based nanoparticles.
Binzel DW, Guo S, Yin H, Lee TJ, Liu S, Shu D, Guo P
Mol Ther Nucleic Acids
July 29, 2021Identification of Arginine Finger as the Starter of the Biomimetic Motor in Driving Double-Stranded DNA.
Liang C, Guo P
ACS Nano
July 2, 2021Radiolabeled RNA Nanoparticles for Highly Specific Targeting and Efficient Tumor Accumulation with Favorable In Vivo Biodistribution.
Wang H, Guo P
Mol Pharm
June 4, 2021Stoichiometry of multi-specific immune checkpoint RNA Abs for T cell activation and tumor inhibition using ultra-stable RNA nanoparticles.
Shu D, Zhang L, Bai X, Yu J, Guo P
Mol Ther Nucleic Acids
May 26, 2021Thermostability, Tunability, and Tenacity of RNA as Rubbery Anionic Polymeric Materials in Nanotechnology and Nanomedicine-Specific Cancer Targeting with Undetectable Toxicity.
Binzel DW, Li X, Burns N, Khan E, Lee WJ, Chen LC, Ellipilli S, Miles W, Ho YS, Guo P
Chem Rev
May 17, 2021Non-Small-Cell Lung Cancer Regression by siRNA Delivered Through Exosomes That Display EGFR RNA Aptamer.
Li Z, Yang L, Wang H, Binzel DW, Williams TM, Guo P
Nucleic Acid Ther
April 12, 2021RNA Nanotechnology to Build a Dodecahedral Genome of Single-Stranded RNA Virus.
Li H, Zhang K, Binzel DW, Shlyakhtenko LS, Lyubchenko Y, Chiu W, Guo P
RNA Biol
December 11, 2020Multivalent rubber-like RNA nanoparticles for targeted co-delivery of paclitaxel and MiRNA to silence the drug efflux transporter and liver cancer drug resistance.
Wang H, Ellipilli S, Lee WJ, Li X, Vieweger M, Ho YS, Guo P
J Control Release
December 1, 20203D RNA nanocage for encapsulation and shielding of hydrophobic biomolecules to improve the in vivo biodistribution.
Xu C, Zhang K, Yin H, Li Z, Krasnoslobodtsev A, Zheng Z, Ji Z, Guo S, Li S, Chiu W, Guo P
Nano Res
September 9, 2020RNA Nanoparticles as Rubber for Compelling Vessel Extravasation to Enhance Tumor Targeting and for Fast Renal Excretion to Reduce Toxicity.
Ghimire C, Wang H, Li H, Vieweger M, Xu C, Guo P
ACS Nano
June 29, 2020Translation of the long-term fundamental studies on viral DNA packaging motors into nanotechnology and nanomedicine.
Liang C, Weitao T, Zhou L, Guo P
Sci China Life Sci
April 20, 2020High resolution structure of hexameric herpesvirus DNA-packaging motor elucidates revolving mechanism and ends 20-year fervent debate.
Guo P
Protein Cell