Philip N Tsichlis, MD
Academic Title: Professor in the College of Medicine
Research Program: Cancer Biology
About Me
More info forI am a professor in the Department of Cancer Biology and Genetics at The Ohio State University and co-leader of the Cancer Biology Program at the OSUCCC – James. I was recruited to Ohio State in 2018 from Tufts University School of Medicine in Boston, where I was executive director of the Molecular Oncology Research Institute.
At The James, my lab focuses on using insertional mutagenesis and other genetic strategies to identify genes involved in causing cancer or regulating phenotypic changes in tumor cells.
I am principal investigator for two studies funded by grants from the National Cancer Institute, including “Differential Regulation of RNA Processing by AKT Isoforms” and “The Role of Iws1 in Development and Tumorigenesis.
In the former, researchers are dissecting molecular mechanisms involved in linking the PI-3K/Akt pathway with RNA splicing and exploring the importance of these findings in lung cancer. In the latter, which is being conducted in conjunction with the lab of Vincenzo Coppola, MD, at Ohio State, researchers are examining the function of the transcription elongation factor Iws1. Based on earlier data from my laboratory, Iws1 plays an important role in human cancer.
I have authored or co-authored dozens of articles in such prestigious scientific journals as Proceedings of the National Academy of Sciences, Nature Microbiology, PLOS One, Science, Journal of Virology and Journal of Immunology.
Academic Office & Contact Information
More info forAcademic Office:
Biomedical Research Tower
460 W 12th Ave
Columbus, Ohio 43210-2210Email:
tsichlis.1@osu.eduPublications
More info forFebruary 16, 2024tRFUniverse: A comprehensive resource for the interactive analyses of tRNA-derived ncRNAs in human cancer.
La Ferlita A, Alaimo S, Nigita G, Distefano R, Beane JD, Tsichlis PN, Ferro A, Croce CM, Pulvirenti A
iScience
November 5, 2023Transcriptional regulation of amino acid metabolism by KDM2B, in the context of ncPRC1.1 and in concert with MYC and ATF4.
Chavdoula E, Anastas V, La Ferlita A, Aldana J, Carota G, Spampinato M, Soysal B, Cosentini I, Parashar S, Sircar A, Nigita G, Sehgal L, Freitas MA, Tsichlis PN
Metabolism
October 31, 2023Expression signature of human endogenous retroviruses in chronic lymphocytic leukemia.
Ferlita A, Nigita G, Tsyba L, Palamarchuk A, Alaimo S, Pulvirenti A, Balatti V, Rassenti L, Tsichlis PN, Kipps T, Pekarsky Y, Croce CM
Proc Natl Acad Sci U S A
October 12, 2023AKT2 Loss Impairs BRAF-Mutant Melanoma Metastasis.
McRee SK, Bayer AL, Pietruska J, Tsichlis PN, Hinds PW
Cancers (Basel)
August 19, 2023Exploiting the fibroblast growth factor receptor-1 vulnerability to therapeutically restrict the MYC-EZH2-CDKN1C axis-driven proliferation in Mantle cell lymphoma.
Sircar A, Singh S, Xu-Monette ZY, Coyle KM, Hilton LK, Chavdoula E, Ranganathan P, Jain N, Hanel W, Tsichlis P, Alinari L, Peterson BR, Tao J, Muthusamy N, Baiocchi R, Epperla N, Young KH, Morin R, Sehgal L
Leukemia
September 13, 2022Transcriptome Analysis of Human Endogenous Retroviruses at Locus-Specific Resolution in Non-Small Cell Lung Cancer.
La Ferlita A, Distefano R, Alaimo S, Beane JD, Ferro A, Croce CM, Tsichlis PN, Pulvirenti A, Nigita G
Cancers (Basel)
July 7, 2022The Role of AKT in Soft Tissue Sarcoma: Review and Insights.
Wang Y, Ilyas FZ, Kheradmandi M, Tsilimigras DI, Grignol VP, Contreras C, Tsichlis PN, Pollock RE, Beane JD
Mol Cancer Res
May 7, 2022AKT inhibition in the central nervous system induces signaling defects resulting in psychiatric symptomatology.
Tsimberidou AM, Skliris A, Valentine A, Shaw J, Hering U, Vo HH, Chan TO, Armen RS, Cottrell JR, Pan JQ, Tsichlis PN
Cell Biosci
April 6, 2022Small Cell Lung Cancer: Subtypes and Therapeutic Implications.
Wang WZ, Shulman A, Amann JM, Carbone DP, Tsichlis PN
Semin Cancer Biol
January 1, 2022Akt isoforms in the immune system.
Guerau-de-Arellano M, Piedra-Quintero ZL, Tsichlis PN
Front Immunol
October 29, 2021PRMT5 Promotes Symmetric Dimethylation of RNA Processing Proteins and Modulates Activated T Cell Alternative Splicing and Ca2+/NFAT Signaling.
Sengupta S, West KO, Sanghvi S, Laliotis G, Agosto LM, Lynch KW, Tsichlis PN, Singh H, Patrick KL, Guerau-de-Arellano M
Immunohorizons
August 7, 2021Hyperlipidemia induced metabolic changes in regulatory T cells result in altered function.
Hyde M, Bagley J, Hinds PW, Tsichlis P, Iacomini J
Eur J Immunol
June 3, 2021RNAdetector: a free user-friendly stand-alone and cloud-based system for RNA-Seq data analysis.
La Ferlita A, Alaimo S, Di Bella S, Martorana E, Laliotis GI, Bertoni F, Cascione L, Tsichlis PN, Ferro A, Bosotti R, Pulvirenti A
BMC Bioinformatics
June 1, 2021PHENSIM: Phenotype Simulator.
Alaimo S, Rapicavoli RV, Marceca GP, La Ferlita A, Serebrennikova OB, Tsichlis PN, Mishra B, Pulvirenti A, Ferro A
PLoS Comput Biol
April 29, 2021Integration of Metabolomics and Gene Expression Profiling Elucidates IL4I1 as Modulator of Ibrutinib Resistance in ABC-Diffuse Large B Cell Lymphoma.
Choueiry F, Singh S, Sircar A, Laliotis G, Sun X, Chavdoula E, Zhang S, Helmig-Mason J, Hart A, Epperla N, Tsichlis P, Baiocchi R, Alinari L, Zhu J, Sehgal L
Cancers (Basel)
November 2, 2020Akt3 induces oxidative stress and DNA damage by activating the NADPH oxidase via phosphorylation of p47phox.
Polytarchou C, Hatziapostolou M, Yau TO, Christodoulou N, Hinds PW, Kottakis F, Sanidas I, Tsichlis PN
Proc Natl Acad Sci U S A
October 27, 2020Akt isoform-specific effects on thyroid cancer development and progression in a murine thyroid cancer model.
Saji M, Kim CS, Wang C, Zhang X, Khanal T, Coombes K, La Perle K, Cheng SY, Tsichlis PN, Ringel MD
Sci Rep
September 22, 2020Targeting phosphatidylinositol 3 kinase-β and -δ for Bruton tyrosine kinase resistance in diffuse large B-cell lymphoma.
Jain N, Singh S, Laliotis G, Hart A, Muhowski E, Kupcova K, Chrbolkova T, Khashab T, Chowdhury SM, Sircar A, Shirazi F, Singh RK, Alinari L, Zhu J, Havranek O, Tsichlis P, Woyach J, Baiocchi R, Samaniego F, Sehgal L
Blood Adv
September 1, 2020Protein Arginine Methyltransferase 5 in T Lymphocyte Biology.
Sengupta S, Kennemer A, Patrick K, Tsichlis P, Guerau-de-Arellano M
Trends Immunol
April 9, 2020Identification of Structural Elements of the Lysine Specific Demethylase 2B CxxC Domain Associated with Replicative Senescence Bypass in Primary Mouse Cells.
Deiktakis EE, Abrams M, Tsapara A, Stournaras C, Tsatsanis C, Tsichlis PN, Kampranis SC
Protein J