Zac Schultz, PhD
Leadership Title: Vice Chair for Graduate Studies, Department of Chemistry and Biochemistry
Academic Title: Associate Professor
Research Program: Molecular Carcinogenesis and Chemoprevention
About Me
More info forI am a member of the Molecular Carcinogenesis and Chemoprevention Program at the OSUCCC – James, where my research focuses on developing instrumentation for the detection of biomolecules and characterization of biological samples.
My lab is funded by the National Cancer Institute (NCI) to develop a method for detecting changes in oncometabolites from tumors. Specifically, sheath-flow surface-enhanced Raman, which was invented in my lab, is being developed for chemical identification and quantitative analysis of metabolites that are challenging to monitor by conventional methods.
Additional research explores plasmonic materials to characterize membrane receptors — specifically, integrins and chemical signaling associated with ligands binding to membrane receptors. Changes in integrin expression have long been associated with the development of cancer, although therapies have been met with mixed success. Our results provide new ways to image and explore ligand-binding to receptors in vitro, which may facilitate cancer therapies.
I have authored or co-authored numerous articles in such peer-reviewed journals as Scientific Reports, Chemical Science, Angewandte Chemie, Analytical Chemistry and Journal of Physical Chemistry.
Research Interests
More info for- Biophysics
- Single Molecule Imaging
- Extracellular Matrix
- Microscopy
- Nanotechnology
- Nanoparticles
- Biosensing Techniques
- Integrins
Education & Training
More info forGraduate Program - PhD
- University of Illinois
Urbana, IL
USA
- University of Illinois
Academic Office & Contact Information
More info forAcademic Office:
Newman and Wolfrom Laboratory
100 W 18th Ave
Columbus, Ohio 43210-1106Phone:
614-292-5775Email:
schultz.133@osu.eduPublications
More info forOctober 16, 2024Machine Learning Classification of Integrin-Expression-Based Magnetic Sorted SW 620 Cells by Simultaneous O-PTIR and SERS.
Rist BL, Witte SA, Schultz ZD
Anal Chem
September 1, 2024Facile synthesis of intra-nanogap enhanced Raman tags with different shapes.
Fan S, Scarpitti BT, Luo Z, Smith AE, Ye J, Schultz ZD
Nano Res
July 3, 2024Comparison of Gap-Enhanced Raman Tags and Nanoparticle Aggregates with Polarization Dependent Super-Resolution Spectral SERS Imaging.
Shoup DN, Fan S, Zapata-Herrera M, Schorr HC, Aizpurua J, Schultz ZD
Anal Chem
July 1, 2024Deep autoencoder as an interpretable tool for Raman spectroscopy investigation of chemical and extracellular vesicle mixtures.
Kazemzadeh M, Martinez-Calderon M, Otupiri R, Artuyants A, Lowe M, Ning X, Reategui E, Schultz ZD, Xu W, Blenkiron C, Chamley LW, Broderick NGR, Hisey CL
Biomed Opt Express
June 28, 2024Surface-Enhanced Raman Spectroscopy Combined with Multivariate Analysis for Fingerprinting Clinically Similar Fibromyalgia and Long COVID Syndromes.
Nuguri SM, Hackshaw KV, Castellvi SL, Wu Y, Gonzalez CM, Goetzman CM, Schultz ZD, Yu L, Aziz R, Osuna-Diaz MM, Sebastian KR, Brode WM, Giusti MM, Rodriguez-Saona L
Biomedicines
June 19, 2024Digital surface enhanced Raman spectroscopy for quantifiable single molecule detection in flow.
Schorr HC, Schultz ZD
Analyst
April 2, 2024Classical vs. quantum plasmon-induced molecular transformations at metallic nanojunctions.
Mantilla ABC, Wang CF, Krayev A, Gu Y, Schultz ZD, El-Khoury PZ
Proc Natl Acad Sci U S A
February 13, 2024A 3D printed sheath flow interface for surface enhanced Raman spectroscopy (SERS) detection in flow.
Morder CJ, Schultz ZD
Analyst
January 9, 2024Early Diagnosis of Fibromyalgia Using Surface-Enhanced Raman Spectroscopy Combined with Chemometrics.
Bao H, Hackshaw KV, Castellvi SL, Wu Y, Gonzalez CM, Nuguri SM, Yao S, Goetzman CM, Schultz ZD, Yu L, Aziz R, Osuna-Diaz MM, Sebastian KR, Giusti MM, Rodriguez-Saona L
Biomedicines
December 19, 2023Bleach Cleaning of Commercially Available Gold Nanopillar Arrays for Surface-Enhanced Raman Spectroscopy (SERS).
Morder CJ, Schorr HC, Balss KM, Schultz ZD
Appl Spectrosc
December 15, 2023Accurate Quantification and Imaging of Cellular Uptake Using Single-Particle Surface-Enhanced Raman Scattering.
Scarpitti BT, Fan S, Lomax-Vogt M, Lutton A, Olesik JW, Schultz ZD
ACS Sens
November 9, 2023From the lab to the field: handheld surface enhanced Raman spectroscopy (SERS) detection of viral proteins.
Payne TD, Klawa SJ, Jian T, Wang Q, Kim SH, Freeman R, Schultz ZD
Sens Diagn
March 28, 2023Chemical conjugation to differentiate monosaccharides by Raman and surface enhanced Raman spectroscopy.
Schorr HC, Schultz ZD
Analyst
November 7, 2022Multipolar Raman Scattering vs Interfacial Nanochemistry: Case of 4-Mercaptopyridine on Gold.
Mantilla ABC, Wang CF, Gu Y, Schultz ZD, El-Khoury PZ
J Am Chem Soc
March 15, 2022In Vitro Imaging of Lycopene Delivery to Prostate Cancer Cells.
Scarpitti BT, Chitchumroonchokchai C, Clinton SK, Schultz ZD
Anal Chem
March 11, 2022Determination of lentiviral titer by surface enhanced Raman scattering.
Morder CJ, Scarpitti BT, Balss KM, Schultz ZD
Anal Methods
December 15, 2021Spectrally Resolved Surface-Enhanced Raman Scattering Imaging Reveals Plasmon-Mediated Chemical Transformations.
de Albuquerque CDL, Zoltowski CM, Scarpitti BT, Shoup DN, Schultz ZD
ACS Nanosci Au
September 7, 2021Catching COVID: Engineering Peptide-Modified Surface-Enhanced Raman Spectroscopy Sensors for SARS-CoV-2.
Payne TD, Klawa SJ, Jian T, Kim SH, Papanikolas MJ, Freeman R, Schultz ZD
ACS Sens
June 2, 2020Super-resolution SERS Imaging of Single Particles in Cells.
Lima de Albuquerque CD, Schultz ZD
Anal Chem
May 26, 2020Potential impact of consolidation radiation therapy for advanced Hodgkin lymphoma: a secondary analysis of SWOG S0816.
Ha CS, LeBlanc M, Schöder H, Pinnix CC, Bartlett NL, Evens AM, Hsi ED, Rimsza L, Knopp MV, Zhang J, Leonard JP, Kahl BS, Li H, Smith S, Constine LS, Friedberg JW
Leuk Lymphoma
April 30, 2020Surface Enhanced Raman Scattering Selectivity in Proteins Arises from Electron Capture and Resonant Enhancement of Radical Species.
Sloan-Dennison S, Zoltowski CM, El-Khoury PZ, Schultz ZD
J Phys Chem C Nanomater Interfaces