Yuntao Bai
Project – The Role of Aquaporins in Cisplatin Transport in Normal and Cancer Cells
Summary – Learn if aquaporins, the water channel proteins, can transport the anticancer drug cisplatin in normal kidney cells and cancer cells. This may provide insight into how to manage the drug toxicity and, in the meanwhile, increase its efficacy in patients.
2017 Pelotonia Participant – Rider: 25 miles
Lindsey Brinton
Project – The Role of BIRC6 Mutation and Aberrant Expression in Acute Myeloid Leukemia
Summary – Attempt to understand what’s happening to cause cancer at a genetic level, the functional consequences in cell function and how this perturbs the body as a system, in order to develop effective treatments and know which patients they will help.
2017 Pelotonia Participant – Rider
Huizi Chen
Project – Characterization of Tumor Heterogeneity and Treatment Resistance in Recurrent Small Cell Lung Cancer
Summary – Characterize tumor heterogeneity in patients with advanced solid tumors harboring driver genomic alterations through rapid research autopsy and whole exome sequencing. Assess whether circulating tumor DNA (ctDNA) is an accurate surrogate for tumor heterogeneity through targeted sequencing.
2017 Pelotonia Participant – Rider: 100 miles
Chih-Hsing Chou
Project – Glycogenomic Vulnerabilities in Acute Myeloid Leukemia (AML)
Summary – Combine analyses of glycogenomic (genes regulating glycan/glycolipid biosynthesis) and glycome (post-translational modification) in an AML model. The study is expected to provide proof of principle for the concept that glycosylation and glycoproteins represent unique vulnerabilities in AML disease development and maintenance.
2017 Pelotonia Participant – Rider: 25 miles
Pedro de la Torre Marquez
Project – Resolving the Structural Determinants of Protocadherin-20 Function in Cancer
Summary – Learn more about the design of selective drugs that modulate protein-protein interactions mediated by PCDH20 and that may be involved in chronic BCP.
2017 Pelotonia Participant – Rider: 25 miles
Sara Elgamal
Project – The role of CLL exosomes in Tumor Mediated Defects in Innate Immunity
Summary – Evaluate how tumor cells in chronic lymphocytic leukemia affect their neighboring cells through the release of small extracellular vesicles. These vesicles include molecules and proteins capable of dampening the immune response thus promoting tumor survival.
2017 Pelotonia Participant – Virtual Rider
Sanjay Mishra
Project – S100A7-mediated cross-talk between adipocytes and triple negative breast cancer
Summary – The aim of this study is to identify S100A7- mediated mechanisms that enhance obesity-induced triple negative breast cancer (TNBC) growth and progression. The completion of this study will help us to develop S100A7 as a novel biomarker and therapeutic target of obese-TNBC patients.
Takehito Shukuya
Project – Investigating extracellular vesicle protein and RNA profiles for biomarkers of response and efficacy in anti PD-1/PD-L1 treated non-small-cell lung cancer
Summary – Perform a direct comparison of RNA and protein in EVs and RNA in plasma from responding and nonresponding patients undergoing single agent PD-1/PD-L1 pathway targeting immunotherapy to define a RNA or protein signature or candidate biomarker for response.