The Pitter Lab work collaboratively to understand the mechanisms of radiation resistance in gastrointestinal malignancies, with the goal of developing an understanding of essential processes in cancer biology to develop novel treatment strategies.
To accomplish this, the Pitter Lab research specialists utilize expertise in genetically engineered murine models of cancer, radiation and cancer biology, single-cell transcriptomics and the functional investigation of cancer cell subpopulations.
The team combines its own intrinsic scientific curiosity with the overarching goal of striving for improved cancer treatment options, which includes discovering new strategies to sensitize otherwise radioresistant tumors.
The lab’s work also strives to better identify which patients will benefit most from radiation therapy. Ionizing radiation plays an important role in treating many cancers, either as definitive, adjuvant or palliative therapy. Yet despite the prevalence of radiation treatment, molecular determinants of clinical benefit remain poorly characterized.
Recent publications include:
- Cell
- Nature Medicine
- Science Translational Medicine
- Cancer Cell
- Journal of the National Cancer Institute
- Clinical Cancer Research