Kalpana Ghoshal, PhD
College of Medicine
Carcinoma, Hepatocellular ● Liver Cancer ● Lymphoma, Non-Hodgkin ● Cancer ● Liver Cancer, Experimental ● Choline Deficiency ● Fatty Liver ● Disease Models, Animal ● Folic Acid Deficiency ● Cell Transformation, Neoplastic
Kalpana Ghoshal, PhD, is an associate professor in the Department of Pathology at Ohio State and a member of the Translational Therapeutics Program at the OSUCCC – James.The goal of Dr. Ghoshal’s research program is to understand the role of microRNAs and DNA methylation machinery in hepatocellular cancer (HCC), the most prevalent liver cancer. The research focuses on gaining mechanistic insight on the molecular basis of HCC that could identify novel biomarkers for diagnosis/prognosis of the disease, and developing agents for prevention and therapy of liver cancer in pre-clinical models. The study could be translated to human HCC patients in collaboration with oncologists at The Ohio State University Comprehensive Cancer Center. Current projects in Dr. Ghoshal’s lab include elucidating the role of miR-122 in liver homeostasis using primary HCCs of human and rodent origins as well as novel mouse models, and the therapeutic delivery of microRNA using nanoparticles or viral vectors. Dr. Ghoshal has authored or co-authored many articles in such well-respected publications as Hepatology, Molecular Cell, American Journal of Pathology, Molecular Cancer Therapeutics and Molecular Cancer Research.