Li Wu, PhD
College of Veterinary Medicine
Molecular Biology and Cancer Genetics
Infection, HIV Infections, Mycosis Fungoides, Sezary Syndrome, Lymphoma, T-Cell, Cutaneous
Dr. Wu's lab aims to better understand the mechanisms of epigenetic silencing of SAMHD1 in CTCL to develop novel therapeutic approaches. Our recent findings suggest that epigenetic silencing of SAMHD1 in malignant CD4+ T-cells contributes to uncontrolled T-cell growth in CTCL. Strategic induction of SAMHD1 expression can be a new therapeutic modality in CTCL.