Li Wu, PhD
College of Veterinary Medicine
Molecular Biology and Cancer Genetics
Infection ● HIV Infections ● Mycosis Fungoides ● Sezary Syndrome ● Lymphoma, T-Cell, Cutaneous
As a member of the College of Veterinary Medicine and College of Medicine at The Ohio State University, Li Wu, PhD, brings a special perspective to the OSUCCC – James Molecular Biology and Cancer Genetics Program. Dr. Wu is an internationally recognized molecular virologist studying HIV replication and pathogenesis. He was elected as a Fellow of the American Association for the Advancement of Science in 2017 in recognition of his distinguished contributions to the field of molecular virology.
Dr. Wu's research also explores the mechanisms of epigenetic silencing of the SAMHD1 gene in cutaneous T-cell lymphoma (CTCL) and acute myeloid leukemia to develop novel therapeutic approaches. Results from his recent findings have suggested that epigenetic silencing of SAMHD1 in malignant CD4+ T-cells contributes to uncontrolled T-cell growth in CTCL. Strategic induction of SAMHD1 expression can be a new therapeutic model in patients with this disease. Moreover, Dr. Wu’s lab reported that SAMHD1 modulates proliferation of acute myeloid leukemia-derived cells through the PI3K-Akt-p27 axis, which inhibits epithelial cell transformation and affects leukemia development in xenograft mice.
As a principal investigator since 2005, Dr. Wu’s research has been continuously funded by the National Institutes of Health (NIH) with over $7.92 million of extramural grants, including 11 NIH grants and 11 grants from private research foundations or intramural resources.
He is the co-holder of three pending patents, including a genetically engineered cell line to study human leukemia, methods and kits for the clinical diagnosis of cutaneous T-cell lymphoma and reactivation of latent HIV-1 for novel and more effective anti-retroviral therapy.
Dr. Wu has co-authored numerous articles appearing in well-respected publications such as eLife, Nature Medicine, Journal of Biological Chemistry and Journal of Virology. He has also published five book chapters and co-edited a book entitled HIV Interactions With Dendric Cells: Infection and Immunity, which was published by Springer Science in 2013. Additionally, Dr. Wu has been invited to share his research in presentations at international institutions and scientific conferences like the Keystone Symposia: HIV Evolution, the Genomics and Pathogenesis Conference, the Retrovirus meeting at the Cold Spring Harbor Laboratory and the Palm Springs Symposium: HIV Disease From Resistance to Cure.