To guide PIIO research efforts, the institute is organized into four interconnected centers of research excellence:
Learn more about the research centers and team members that are part of the Pelotonia Institute for Immuno-Oncology.
To guide PIIO research efforts, the institute is organized into four interconnected centers of research excellence:
Cancer Immuno-Genomics, a program conducted in partnership with Nationwide Children’s Hospital which involves understanding the relationship between cancer genomics and immune evasion and includes epigenetics, neo-antigen vaccine, epitope prediction, TCR repertoire analysis, HLA typing, and CRISPR screening.
Cell Therapy, where immune cells are collected from a patient’s blood, engineered, and returned to that patient to target and eradicate cancer and includes adoptive cell therapy with T cells and natural killer cells.
Systems Immuno-Oncology, which seeks a better understanding of cellular systems to create more efficient and effective immunological tools to fight cancer and includes immune regulation, innate immunity and inflammation, microbiome, NK and T cell biology, and tumor microenvironment.
Translational Immuno-Oncology, an area that focuses on transforming immuno-oncology discoveries into new or improved cancer treatments applicable at patient bedsides. This team works with the Drug Development Institute at the OSUCCC – James on developing new drug therapies.
Immuno-Informatics (Data Science), where big data and quantitative science is used to improve immuno-oncology research and includes machine learning, neo-antigen discovery, spatial statistics, etc.
Immune Monitoring and Discovery Platform, which is backed by a new facility with technology that allows scientists to get a 360-degree view—down to the single-cell level—of what happens in the immune system during treatment with immuno-oncology agents.