Medicinal Chemistry
The DDSR-MC core is housed in dedicated lab space in 335 Parks Hall in the College of Pharmacy on The Ohio State University main campus. It includes standard equipment for organic synthesis and chemical analysis, five 8-foot chemical fume hoods and one 6-foot floor mount fume hood containing a solvent purification system.
ACCQPrep HP150 Prep HPLC System: A preparative reverse phase HPLC system with automated fraction collector and UV and ELSD detectors.
Advion Expression ® S Compact Mass Spectrometer: A compact mass spectrometer with single decimal place mass resolution. Capable of switching between Atmospheric Pressure Chemical Ionization (APCI) and Electrospray Ionization (ESI) sources. Mass range: m/z 10 – 1,200 units. Equipped with a Plate Express™ TLC plate reader for quick analysis of an analyte on a TLC plate and an Atmospheric Solids Analysis Probe (ASAP®) for one-touch analysis of solid and liquid samples.
Thales Nano H-Cube ® Mini Plus Flow Hydrogenator: A safe and efficient benchtop, flow reactor hydrogenation system that generates hydrogen from water via electrolysis within the machine. Capable of pressures and temperatures up to 100 bar and 100 ⁰C.
Teledyne-ISCO CombiFlash ® RF+ Lumen Purification System: Automated chromatography purification instrument. Equipped with UV and ELSD detectors.
CEM Discover 2.0 ® Microwave Reactor: A microwave reactor used for carrying out high temperature and pressure reactions. Equipped with a flow cell reactor.
Inert ® PureSolv MD7 Solvent Purification System: Seven solvent purification system that generates anhydrous and air-free solvents. Solvents included: dichloromethane, tetrahydrofuran, 1,4-dioxane, dimethylformamide, methyl tertbutyl ether, toluene, and acetonitrile.
Buchi Lyovapor™ L-250 Basic Lyophilizer: A lyophilizer used for freeze drying samples. Equipped with a –85 °C condenser and ≤5kg condenser capacity.
High-Throughput Screening
The DDSR-HTS provides state-of-art equipment for high-throughput and high-content screening, including both automation and detection, in newly renovated space in 345 Parks Hall. Ancillary instruments are provided for cell culture, liquid handling, compound management and data/image analysis. We offer a streamlined and versatile workflow for early drug discovery, target/mechanism of action identification and molecular probe development.
Our instruments include:
Perkin-Elmer Opera Phenix Plus with four high-powered lasers (405 nm, 488 nm, 561 nm, and 640 nm), an onboard liquid handling system and live cell automation capability
Echo 650 Acoustic Liquid Handler
Biotek Multiflo FX with plate stacker
Tecan Spark Cyto 600 Multi-Mode Plate Reader
SpectraMax i3 Multi-Mode Plate Reader
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Other ancillary instruments:
- Agilent PlateLoc plate sealer
- Centrifuges
- Mammalian (CO2) and microbial cell culture incubators
- Class II A2 biosafety cabinets
- Electronic laboratory notebooks (CDDVault, Microsoft Note)
- Cheminformatics software (SpotFire, CDDVault, ChemOffice)